Zeitschrift für Phytotherapie 2021; 42(04): 175-180
DOI: 10.1055/a-1406-4277
Forschung

Wirkmechanismen von Duftstoffen und ätherischen Ölen: Wie beeinflussen sie Emotionen und kognitive Leistungen?

Eva Heuberger

Zusammenfassung

Klinische Studien zur Wirksamkeit von Aromatherapie attestieren ätherischen Ölen ein großes Potenzial für die Behandlung von affektiven Beschwerden und kognitiven Defiziten. Nach Jellinek basiert die psychogene Wirksamkeit von ätherischen Ölen und Duftstoffen jedoch nicht nur auf pharmakologischen, sondern auch auf psychologischen Wirkmechanismen, sodass die resultierenden Effekte durch verschiedene, intrapersonelle Faktoren beeinflusst werden können. In diesem Beitrag werden die einzelnen Mechanismen vorgestellt und anhand von Beispielen aus der Emotions- und Kognitionsforschung diskutiert. Der Zusammenhang zwischen Anwendungsart und Wirksamkeit von ätherischen Ölen wird ebenso beleuchtet wie ihre möglichen unerwünschten Wirkungen. Die Kenntnis der verschiedenen Wirkmechanismen ermöglicht einen gezielten Einsatz von ätherischen Ölen und kann die Aromatherapie zu einer noch effizienteren phytotherapeutischen Behandlungsform machen.SchlüsselwörterAromatherapie, Kognition, Emotion, olfaktorische Stimuli,hedonische Valenz

Abstract

Mechanisms of Action of Fragrances and Essential Oils: Effect on Emotions and Cognitive Performance

Clinical research on the efficacy of aromatherapy has demonstrated that essential oils are highly valuable in the treatment of emotional and cognitive discomfort. However, according to Jellinek, the psychodynamic effects of essential oils and odorants are mediated not only by straight-forward pharmacological but also by psychological mechanisms. Thus, their observable therapeutic effects may be influenced by various individual factors. This paper introduces Jellinek’s model and relates its postulated mechanisms to recent affective and cognitive research. A spotlight will be set on the relationship between the efficacy of essential oils and the route of application as well as on potential undesirable effects. Knowledge of the underlying mechanisms allows for a targeted use of essential oils and will make aromatherapy an even more efficient form of phytotherapeutic treatment.



Publication History

Article published online:
01 September 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Friedl SM, Heuberger E, Oedendorfer K. et al. Quantification of 1,8-cineole in human blood and plasma and the impact of liner choice in head-space chromatography. Curr Bioact Compd 2015; 11: 49-55
  • 2 Agatonovic-Kustrin S, Chan CKY, Gegechkori V. et al. Models for skin and brain penetration of major components from essential oils used in aromatherapy for dementia patients. J Biomol Struct Dyn 2020; 38: 2402-2411
  • 3 Pudełek M, Catapano J, Kochanowski P. et al. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro. Fitoterapia 2019; 134: 172-181
  • 4 Kennedy D, Okello E, Chazot P. et al. Volatile terpenes and brain function: investigation of the cognitive and mood effects of Mentha x piperita L. essential oil with in vitro properties relevant to central nervous system function. Nutrients 2018; 10: 1029
  • 5 Lopez V, Nielsen B, Solas M. et al. Exploring pharmacological mechanisms of lavender (Lavandula angustifolia) essential oil on central nervous system targets. Front Pharmacol 2017; 8: 280
  • 6 Baldinger P, Höflich AS, Mitterhauser M. et al. Effects of Silexan on the serotonin-1A receptor and microstructure of the human brain: a randomized, placebo-controlled, double-blind, cross-over study with molecular and structural neuroimaging. Int J Neuropsychopharmacol 2015; 18: 63
  • 7 Albrecht J, Wiesmann M.. Das olfaktorische System des Menschen. Anatomie und Physiologie. Nervenarzt 2006; 77: 931-939
  • 8 Kontaris I, East BS, Wilson DA.. Behavioral and neurobiological convergence of odor, mood and emotion: a review. Front Behav Neurosci 2020; 14: 35
  • 9 Herz RS.. The role of odor-evoked memory in psychological and physiological health. Brain Sci 2016; 6: 22
  • 10 Heuberger E. Effects of essential oils on human cognition. In Başer KHC, Buchbauer G (eds). Handbook of Essential Oils: Science, Technology, and Applications. 3rd ed. Boca Raton, FL: CRC Press; 2021: 345–371
  • 11 Sturm W, de Simone A, Krause BJ. et al. Functional anatomy of intrinsic alertness: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere. Neuropsychologia 1999; 37: 797-805
  • 12 Petersen SE, Posner MI.. The attention system of the human brain: 20 years after. Annu Rev Neurosci 2012; 35: 73-89
  • 13 Jellinek JS.. Psychodynamic odor effects and their mechanisms: failure to identify the mechanism can lead to faulty conclusions in odor studies. Cosmet Toilet 1997; 112: 61-71
  • 14 Hoenen M, Muller K, Pause BM. et al. Fancy citrus, feel good: positive judgment of citrus odor, but not the odor itself, is associated with elevated mood during experienced helplessness. Front Psychol 2016; 7: 74
  • 15 Redd WH, Manne SL, Peters B. et al. Fragrance administration to reduce anxiety during MR imaging. J Magn Reson Imaging 1994; 4: 623-626
  • 16 Chu S.. Olfactory conditioning of positive performance in humans. Chem Senses 2008; 33: 65-71
  • 17 Robin O, Alaoui-Ismaïli O, Dittmar A. et al. Basic emotions evoked by eugenol odor differ according to the dental experience. A neurovegetative analysis. Chem Senses 1999; 24: 327-335
  • 18 Campenni CE, Crawley EJ, Meier ME.. Role of suggestion in odor-induced mood change. Psychol Rep 2004; 94: 1127-1136
  • 19 Abramowitz EG, Lichtenberg P.. Hypnotherapeutic olfactory conditioning (HOC): case studies of needle phobia, panic disorder, and combat-induced PTSD. Int J Clin Exp Hypn 2009; 57: 184-197
  • 20 Tildesley NTJ, Kennedy DO, Perry EK. et al. Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav 2005; 83: 699-709
  • 21 Heuberger E, Redhammer S, Buchbauer G.. Transdermal absorption of (–)-linalool induces autonomic deactivation but has no impact on ratings of well-being in humans. Neuropsychopharmacology 2004; 29: 1925-1932
  • 22 Hongratanaworakit T, Buchbauer G.. Evaluation of the harmonizing effect of ylang-ylang oil on humans after inhalation. Planta Med 2004; 70: 632-636
  • 23 Stappen I, Hölzl A-S, Randjelovic O. et al. Influence of essential ginger oil on human psychophysiology after inhalation and dermal application. Nat Prod Commun 2016; 11: 1565-1568
  • 24 Heuberger E, Ilmberger J, Hartter E. et al. Physiological and behavioral effects of 1,8-cineol and (±)-linalool: A comparison of inhalation and massage aromatherapy. Nat Prod Commun 2008; 3: 1103-1110
  • 25 Ambrosch S, Duliban C, Heger H. et al. Effects of 1,8-cineole and (–)-linalool on functional brain activation in a working memory task. Flavour Fragr J 2018; 33: 1-10
  • 26 Niedner R.. Glukokortikosteroide in der Dermatologie. Kontrollierter Einsatz erforderlich. Dtsch Arztebl 1996; 93: A-2868-2872
  • 27 Friedl SM, Oedendorfer K, Kitzer S. et al. Comparison of liquid-liquid partition, HS-SPME and static HS GC/MS analysis for the quantification of (–)-linalool in human whole blood samples. Nat Prod Commun 2010; 5: 1447-1452
  • 28 Cortese B, Leslie K, Grubaugh A. et al. Olfactory function and fear-related odor cues in combat veterans with and without PTSD. Neuropsychopharmacology 2014; 39: S229-S230
  • 29 Vermetten E, Schmahl C, Southwick SM. et al. Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder. Psychopharmacol Bull 2007; 40: 8-30
  • 30 Toffolo MB, Smeets MA, van den Hout MA.. Proust revisited: odours as triggers of aversive memories. Cogn Emot 2012; 26: 83-92
  • 31 Weber ST, Heuberger E.. The impact of natural odors on affective states in humans. Chem Senses 2008; 33: 441-447
  • 32 Heuberger E, Römer S, Michael T.. Context odors affect extinction learning. 5th Eur Meet Hum Fear Cond. 2013 Belgium: Affligem.
  • 33 Heuberger E, Roemer S, Michael T.. Do pleasant ambient odors enhance extinction learning? 6th Eur Meet Hum Fear Cond. 2014 Belgium: Affligem.
  • 34 Heuberger E, Bonarius A, Michael T.. Der Geruchssinn bei Patienten mit Angststörungen. PiD – Psychother im Dialog 2015; 16: 83-85