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Synlett 2021; 32(13): 1309-1315
DOI: 10.1055/a-1409-2734
DOI: 10.1055/a-1409-2734
cluster account
Perspectives on Organoheteroatom and Organometallic Chemistry
Strategies of In Situ Generated Magnesium Catalysis in Asymmetric Reactions
We acknowledge financial support from the National Natural Science Foundation of China (NSFC; 21901092), the Innovation fund for medical sciences (2019-12M-5-074), the Funds for Fundamental Research Creative Groups of Gansu Province (20JR5RA310), and the Fundamental Research Funds for the Central Universities (lzujbky-2020-49).
Abstract
Magnesium (Mg) is a cheap, non-toxic, and recyclable alkaline earth metal that constitutes about 2% weight in the Earth’s crust. The use of magnesium catalysts to forge chiral moieties in molecules is highly attractive. Based on our work in recent years, we describe the current progress in the development of in situ generated magnesium catalysts and their application in asymmetric synthesis. In this perspective, a critically concise classification of in situ generated magnesium catalytic modes, with relevant examples, is presented, and representative mechanisms of each category are discussed. Building on the established diverse strategies, one can foresee that more innovative and structurally creative magnesium catalysts that are generated in situ will be developed to overcome more formidable challenges of catalytic enantioselective reactions.
1 Introduction
2 Magnesium Catalysts Generated in Situ from Chiral Ligands Containing Dual Reactive Hydrogens
3 Magnesium Catalysts Generated in Situ from Monoanionic Chiral Ligands
4 Bimetallic and Polymetallic Magnesium Catalysts Assembled in Situ
5 Summary and Outlook
Key words
magnesium - in situ assembly - asymmetric synthesis - catalytic strategies - chiral ligandPublication History
Received: 04 January 2021
Accepted after revision: 05 March 2021
Accepted Manuscript online:
05 March 2021
Article published online:
07 April 2021
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For recent examples of the use of Box-Mg(II) in enantioselective synthesis, see:
For recent examples of enantioselective hydroboration of ketones, see:
For recent examples, see:
For elegant examples of Cu-catalyzed intermolecular asymmetric vinylogous reactions of allylic esters, see:
For recent examples, see:
For reviews on catalytic asymmetric dearomatization reactions, see: