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DOI: 10.1055/a-1425-5987
Der tiefe sternale Wundinfekt nach Sternotomie
Konsensus-Bericht der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße (DAM)Deep sternal wound infection after sternotomyReport of the consensus workshop of the German-Speaking Society for Microsurgery of Peripheral Nerves and Vessels (DAM)Zusammenfassung
Der tiefe sternale Wundinfekt (TSWI) ist eine seltene Komplikation nach Sternotomie, die mit hoher Morbidität und Mortalität behaftet ist und Krankenhausaufenthalt sowie die Behandlungskosten signifikant ansteigen lässt. Eine mikrobiologische Besonderheit ist die Ausbildung von Biofilmen auf Implantatmaterial und/oder Knochensequestern. Die Diagnose wird anhand der klinischen Symptomatik der lokalen Entzündungsreaktion gestellt und durch systemische Infektionszeichen gestützt. Eine frühzeitige und gemeinsame Konsensfindung, welche die oft interdisziplinäre Behandlungsstrategie festlegt, ist dabei essenziell. Die Behandlung besteht i. d. R. aus mehreren chirurgischen Wunddebridements mit zwischenzeitlicher Wundkonditionierung, bis ein ausreichend sauberer Wundstatus erreicht ist. Zur Infektsanierung und für den Wundverschluss stehen je nach Größe und Lokalisation des Gewebedefektes eine Vielzahl verschiedener gestielter und freier Lappenplastiken zur Auswahl.
Abstract
Deep sternal wound infection (TSWI) is a potentially life-threatening complication that may occur after median sternotomy, contributing to prolonged hospital stay and increased health care costs. Bacterial infection is often characterized by biofilm formation on implant material and/or dead bone. Diagnosis is made upon clinical signs and symptoms of local and systemic infection. Early multidisciplinary decision making is needed for optimal patient care. Repeated surgical wound debridements accompanied by wound conditioning are performed until clean circumstances are achieved. Thereafter, wound closure and defect reconstruction are obtained using a variety of pedicled and microvascular flaps.
Publication History
Received: 13 January 2021
Accepted: 01 March 2021
Article published online:
05 May 2021
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Literatur
- 1 Zimmerli W, Sendi P. Orthopaedic biofilm infections. APMIS 2017; 125: 353-364
- 2 Yusuf E, Chan M, Renz N. et al. Current perspectives on diagnosis and management of sternal wound infections. Infect Drug Resist 2018; 11: 961-968
- 3 Saeed K, McLaren A, Schwarz E. et al. 2018 international consensus meeting on musculoskeletal infection: summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections. J Ortho Res 2019; 37: 1007-1017
- 4 Aricola C, An Y, Campoccia D. et al. Etiology of implant orthopedic infections: a survey on 1027 clinical isolates. Int J Artif Organs 2005; 28: 1091-1100
- 5 Global guidelines for the prevention of surgical site infection. World health organization. Geneva: 2016 http://www.who.int aufgerufen 12/2020
- 6 Pairolero P, Arnold P. Management of infected median sternotomy wounds. Ann Thorac Surg 1986; 42: 1-2
- 7 Lew D, Waldvogel F. Osteomyelitis. Lancet 2004; 364: 369-79
- 8 Phoon PHY, Hwang NC. Deep Sternal Wound Infection: Diagnosis, Treatment and Prevention. J Cardiothorac Vasc Anesth 2020; 34: 1602-1613
- 9 Strecker T, Rosch J, Horch R. et al. Sternal wound infections following cardiac surgery: risk factor analysis and interdisciplinary treatment. Heart Surg Forum 2007; 10: 366-371
- 10 Berdajs D, Trampuz A, Ferrari E. et al. Delayed primary versus late secondary wound closure in the treatment of postsurgical sternum osteomyelitis. Interact Carciovasc Thorac Surg 2011; 12: 914-918
- 11 Biancari F, Gatti G, Rosato S. et al. Preoperative risk stratification of deep sternal wound infection after coronary surgery. Infect Control Hosp Epidemiol 2020; 41: 444-451
- 12 Reser D, Rodriguez H, Plass A. et al. Incidence of sternal wound infection after reexploration in the intensive care unit and the use of local gentamycin. Ann Thorac Surg 2012; 94 (06) 2033-2037
- 13 Andreas M, Zeitlinger M, Hoeferl M. et al. Internal mammary artery harvesting influences antibiotic penetration into prestenal tissue. Ann Thorac Surg 2013; 95: 1323-1329
- 14 Trick W, Scheckler W, Tokars J. et al. Risk factors for radial artery harvest site infection following coronary artery bypass graft surgery. Clin Infect Dis 2000; 30: 270-275
- 15 Ariyaratnam P, Bland M, Loubani M. Risk factors and mortality associated with deep sternal wound infections following coronary bypass surgery with or without concomitant procedures in a UK population: a basis for a new risk model?. Interact Cardiovasc Thorac Surg 2010; 11: 543-546
- 16 Hamilton K, Wolfswinkel E, Weathers W. et al. The delay phenomenon: A compilation of knowledge across specialties. Craniomaxillofac Trauma Reconstr 2014; 7: 112-118
- 17 Tabor O, Boss M, Hudson M. et al. Does bacteremia occur during high pressure lavage of contaminated wounds?. Clin Orthop Relat Res 1998; 347: 117-121
- 18 Colsky A, Kirsner R, Kerdel F. Analysis of antibiotic susceptibilities of skin wound flora in hospitalized dermatology patients. The crisis of antibiotic resistance has come to the surface. Arch Dermatol 1998; 134: 1006-1009
- 19 Zeitani J, Penta de Peppo A, Moscarelli M. et al. Influence of sternal size and inadvertent paramedian sternotomy on stability of the closure site: a clinical and mechanical study. J Thorac Cardiovasc Surg 2006; 132: 38-42
- 20 Chan M, Yusuf E, Giulieri S. et al. A retrospective Study of deep sternal wound infections: clinical and microbiological characteristics, treatment, and risk factors of complications. Diagn Microbiol Infect Dis 2016; 84: 261-265
- 21 Morisaki A, Hosono M, Murakami T. et al. Effect of negative pressure wound therapy followed by tissue flaps for deep sternal wound infection after cardiovascular surgery: propensity score matching analysis. Interact Cardiovasc Thoracic Surg 2016; 23: 397-402
- 22 Hwang NC. Deep sternal wound Infection: Diagnosis, Treatment and Prevention. J Cardiothor Vasc Anaes 2020; 34 (06) 1602-1613
- 23 Popov AF, Schmitto J, Jebran AF. et al. Treatment of gram-positive deep sternal wound infections in Cardiac Surgery – experiences with daptomycin. J Cardiothor Surg 2011; 6: 112
- 24 Khanlari B, Elzi L, Estermann L. et al. A rifampicin-containing treatment improves outcome of staphylococcal deep sternal wound infections. J Antimicobial Chemother 2010; 65: 1799-1806
- 25 Mokhtari A, Petzina R, Gustafsson L. et al. Sternal stability at different negative pressures during vacuum-assisted closure therapy. Ann Thorac Surg 2006; 82: 1063-1067
- 26 Kim P, Attinger C, Constantine T. et al. Negative pressure wound therapy with instillation: International consensus guidelines update. Int Wound J 2020; 17: 174-186
- 27 Bapat V, El-Muttardi N, Young C. et al. Experience with vacuum-assisted closure of sternal wound infections following cardiac surgery and evaluation of chronic complications associated with its use. J Card Surg 2008; 23: 227-233
- 28 Levin L, Miller A, Gajjar A. et al. An innovative approach for sternal closure. Ann Thorac Surg 2010; 89: 1995-1999
- 29 Leinberger T, Heilmann C, Sorg S. et al. The COSTA Study: Sternal Closure in High-Risk Patients – A Prospective Randomized Multicenter Trial. Thorac Cardiovasc Surg 2018; 66: 508-516
- 30 Hauser J, Steinau H, Ring A. et al. Sternal osteomyelitis. Etiology, diagnostics and operative therapy concepts. Chirurg 2014; 85: 357-365
- 31 Murphy R, Robson M, Heggers J. et al. The effect of microbial contamination on musculocutaneous and random flaps. J Surg Res 1986; 41: 75-80
- 32 Sofiadellis F, Liu DS, Webb A. et al. Fasciocutaneous free flaps are more reliable than muscle free flaps in lower limb trauma reconstruction: experience in a single trauma center. J Reconstr Microsurg 2012; 28: 333-340
- 33 Horch RE, Willy C, Kutschka I. Deep sternal wound infections. Springer-Verlag Berlin Heidelberg; 2016 DOI: 10.1007/978-3-662-49766-1
- 34 Dejesus R, Paletta J, Dabb R. Reconstruction of the median sternotomy wound dehiscence using the latissimus dorsi myocutaneous flap. J Cardiovasc Surg 2001; 42: 359-364
- 35 Molenkamp S, Waterbolk TW, Mariani MA. et al. Predictors of complications after pectoralis major transposition for sternum dehiscence. Ann Plast Surg 2017; 78: 208-212
- 36 Izaddoost S, Withers EH. Sternal reconstruction with omental and pectoralis flaps: a review of 415 consecutive cases. Ann Plast Surg 2012; 69: 296-300
- 37 Berg LT, Jaakkola P. Kuopio treatment strategy after deep sternal wound infection. Scand J Surg 2013; 102: 3-8
- 38 Zhang H, Lin L, Yang H. et al. Bilateral partial pectoralis major muscle turnover flaps for the management of deep sternal wound infection following cardiac surgery. J Thorac Dis 2020; 12: 6010-6015
- 39 Beier J, Arkudas A, Lang W. et al. Sternumosteomyelitis – chirurgische Behandlungskonzepte. Chirurg 2016; 6: 537-547
- 40 Erni D, Harder Y. The dissection of the rectus abdominis myocutaneous flap with complete preservation of the anterior rectus sheath. Br J Plast Surg 2003; 56: 395-400
- 41 Tassi V, Ceccarelli S, Vannucci J. et al. Mediastinitis and sternal prosthesis infection successfully treated by minimally invasive omental flap transposition. J Cardiothorac Surg 2013; 25: 30
- 42 Van Wingerden JJ, Lapid O, Boonstra PW. et al. Muscle flaps or omental flap in the management of deep sternal wound infection. Interact Cardiovasc Thorac Surg 2011; 13: 179-187
- 43 Kolbenschlag J, Hörner C, Sogorski A. et al. Sternal Reconstruction with the Omental Flap – Acute and Late Complications, Predictors of Mortality, and Quality of Life. J Reconstr Microsurg 2018; 34: 376-382
- 44 Ehrl D, Broer P, Ninkovic M. et al. Extending the Indication of the Superior Thyroid Artery as a Recipient Vessel for Complex Upper Body Defects. Ann Plast Surg; 2020 Online ahead of print
- 45 Dornseifer U, Kleeberger C, Ehrl D. et al. Arteriovenous Loop-Independent Free Flap Reconstruction of Sternal Defects after Cardiac Surgery. J Reconstr Microsurg 2016; 32: 506-512
- 46 Taeger C, Horch R, Arkudas A. et al. Combined free flaps with arteriovenous loops for reconstruction of extensive thoracic defects after sternal osteomyelitis. Microsurgery 2016; 36: 121-127
- 47 Engel H, Pelzer M, Sauerbier M. et al. An innovative treatment concept for free flap reconstruction of complex central chest wall defects: The cephalic-thoraco-acromial (CTA) loop. Microsurgery 2007; 27: 481-486