Update Breast Cancer 2021 Part 2 – Advanced Stages, Long-Term Consequences and Biomarkers

Nina Ditsch; Elmar Stickeler; Annika Behrens; Erik Belleville; Peter A. Fasching; Tanja N. Fehm; Andreas D. Hartkopf; Christian Jackisch; Wolfgang Janni; Cornelia Kolberg-Liedtke; Hans-Christian Kolberg; Diana Lüftner; Michael P. Lux; Volkmar Müller; Andreas Schneeweiss; Florian Schütz; Carla E. Schulmeyer; Hans Tesch; Christoph Thomssen; Christoph Uleer; Michael Untch; Manfred Welslau; Achim Wöckel; Lena A. Wurmthaler; Rachel Würstlein; Marc Thill; Bahriye Aktas

doi:10.1055/a-1464-1221

Geburtshilfe und Frauenheilkunde, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(05): 539-548
DOI: 10.1055/a-1464-1221

GebFra Science

Review/Übersicht

Update Breast Cancer 2021 Part 2 – Advanced Stages, Long-Term Consequences and Biomarkers

Artikel in mehreren Sprachen: English | deutsch

Nina Ditsch

¹Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Elmar Stickeler

²Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

,

Annika Behrens

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Erik Belleville

⁴ClinSol GmbH & Co. KG, Würzburg, Germany

,

Peter A. Fasching

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Tanja N. Fehm

⁵Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Andreas D. Hartkopf

⁶Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Christian Jackisch

⁷Department of Obstetrics and Gynecology, Sana Klinikum Offenbach, Offenbach, Germany

,

Wolfgang Janni

⁸Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Cornelia Kolberg-Liedtke

⁹Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

,

Hans-Christian Kolberg

¹⁰Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Diana Lüftner

¹¹Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany

,

Michael P. Lux

¹²Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany

,

Volkmar Müller

¹³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Andreas Schneeweiss

¹⁴National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

,

Florian Schütz

¹⁵Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Carla E. Schulmeyer

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Hans Tesch

¹⁶Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany

,

Christoph Thomssen

¹⁷Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Christoph Uleer

¹⁸Praxisgemeinschaft Frauenärzte am Bahnhofsplatz, Hildesheim, Germany

,

Michael Untch

¹⁹Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Manfred Welslau

²⁰Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Achim Wöckel

²¹Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Lena A. Wurmthaler

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Rachel Würstlein

²²Breast Center, Department of Gynecology and Obstetrics and CCC Munich Ludwig Maximilians University, LMU University Hospital, Munich, Germany

,

Marc Thill

²³Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt, Germany

,

Bahriye Aktas

²⁴Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Leipzig, Leipzig, Germany

› Institutsangaben

Abstract

This review summarises and discusses significant aspects of recently published studies on patient treatment in advanced breast cancer and on biomarkers in breast cancer. In recent years, a large number of drugs for all molecular subtypes have been developed up to phase III trials. With regard to immune checkpoint inhibitors in metastasised breast cancer, the recent discussion has centred on the best candidate for combined chemotherapy. The oral taxanes could become a new type of oral chemotherapies. There is a growing body of data on biomarkers for the use of CDK4/6 inhibitors, which could also signify further development for other molecular subtypes. New substances have been developed for metastatic HER2+ breast cancer that still result in good remission even after massive prior treatment and/or cerebral metastasis. Similarly, knowledge is growing about targeted therapies with antibody-drug conjugates (ADC) against Trop-2, which could bolster our therapeutic armoury in triple-negative breast cancer (TNBC). In addition, the clinical focus is on understanding how to maintain fertility after breast cancer treatment. Here, pooled analyses provide new insights.

Key words

advanced breast cancer - biomarkers - therapy - prognosis

Volltext

Referenzen

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