Immunology and Immune Checkpoint Inhibition in Ovarian Cancer – Current Aspects

Holger Bronger

doi:10.1055/a-1475-4335

Geburtshilfe und Frauenheilkunde, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(10): 1128-1144
DOI: 10.1055/a-1475-4335

GebFra Science

Review/Übersicht

Immunologie und Immuncheckpoint-Inhibition des Ovarialkarzinoms – aktuelle Aspekte

Artikel in mehreren Sprachen: English | deutsch

Holger Bronger

¹Klinik und Poliklinik für Frauenheilkunde, Klinikum rechts der Isar, Technische Universität München, München, Germany

²Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partnerstandort München und Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

› Institutsangaben

Abstract

Zusammenfassung

Immuntherapien wie die Immuncheckpoint-Blockade (ICB) gegen das PD-1/PD-L1-System haben in der letzten Dekade die Behandlung zahlreicher Entitäten revolutioniert. Das Ovarialkarzinom ist bislang von diesen Erfolgen weitestgehend ausgenommen. Mögliche Ursachen liegen in einer gegenüber anderen Tumorarten vergleichsweise niedrigen Mutationslast, einer unzureichenden Präsentation von (Neo-)Antigenen sowie einer erhöhten Infiltration mit immunsuppressiven Immunzellen wie regulatorischen T-Zellen oder tumorassoziierten Makrophagen. In den bisher durchgeführten klinischen Studien waren die Ansprechraten auf Inhibitoren des PD-1/PD-L1-Checkpoints dementsprechend auch enttäuschend niedrig, jedoch zeigen sich auch beim Ovarialkarzinom vereinzelte Langzeitremissionen. Es gilt nun, einerseits geeignete prädiktive Biomarker zu finden, andererseits Kombinationspartner für die ICB-Therapie zu identifizieren, welche die Immunogenität des Ovarialkarzinoms erhöhen bzw. immunsuppressive Resistenzmechanismen durchbrechen können. Der vorliegende Artikel gibt eine Übersicht über das Immunmilieu im Ovarialkarzinom, dessen Einfluss auf die Wirkung einer ICB und fasst die bislang vorliegenden klinischen Studiendaten zur ICB beim Ovarialkarzinom zusammen.

Schlüsselwörter

Ovarialkarzinom - Immuncheckpoint-Blockade - PD-L1 - tumorinfiltrierende Lymphozyten

Volltext

Referenzen

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