Update Breast Cancer 2021 Part 3 – Current Developments in the Treatment of Early Breast Cancer: Review and Assessment of Specialised Treatment Scenarios by an International Expert Panel

Tanja N. Fehm; Elmar Stickeler; Peter A. Fasching; Wolfgang Janni; Cornelia Kolberg-Liedtke; Hans-Christian Kolberg; Diana Lüftner; Volkmar Müller; Florian Schütz; Christoph Thomssen; Erik Belleville; Annika Behrens; Simon Bader; Michael Untch; Manfred Welslau; Rachel Würstlein; Marc Thill; David Krug; Andreas D. Hartkopf

doi:10.1055/a-1487-7642

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(06): 654-665
DOI: 10.1055/a-1487-7642

GebFra Science

Review/Übersicht

Update Breast Cancer 2021 Part 3 – Current Developments in the Treatment of Early Breast Cancer: Review and Assessment of Specialised Treatment Scenarios by an International Expert Panel

Article in several languages: English | deutsch

Tanja N. Fehm

¹Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Elmar Stickeler

²Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

,

Peter A. Fasching

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁴Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Cornelia Kolberg-Liedtke

⁵Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

⁶palleos healthcare, Wiesbaden, Germany

⁷Phaon Scientific, Wiesbaden, Germany

,

Hans-Christian Kolberg

⁸Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Diana Lüftner

⁹Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany

,

Volkmar Müller

¹⁰Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Florian Schütz

¹¹Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Christoph Thomssen

¹²Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Erik Belleville

¹³ClinSol GmbH & Co KG, Würzburg, Germany

,

Annika Behrens

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Simon Bader

³Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Michael Untch

¹⁴Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Manfred Welslau

¹⁵Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Rachel Würstlein

¹⁶Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

,

Marc Thill

¹⁷Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt, Germany

,

David Krug

¹⁸Department of Radiation Oncology, University Hospital of Schleswig-Holstein, Kiel, Germany

,

Andreas D. Hartkopf

¹⁹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

› Author Affiliations

Abstract

The continuous availability of findings from new studies repeatedly results in updated treatment recommendations and guidelines. In the case of breast carcinoma in particular, several studies have been published in the last few years that have transformed how early and advanced breast carcinoma is being treated. However, this by no means means implies that there is agreement among all experts on specific issues. It is precisely the diversity of interpretation of guidelines and study findings that reflects the constantly changing available data and its complexity, as well as the availability of new drugs. In recent years, new substances such as pertuzumab, T-DM1, neratinib and capecitabine have become available to treat patients with early stages of breast carcinoma. Furthermore, the first results on the use of CDK4/6 inhibitors for adjuvant treatment have now been published. Last but not least, the use of multigene tests to avoid the necessity of chemotherapy in certain patients is still under discussion. This review summarises the state of the data and publishes the results of the survey completed by experts at the 2021 St. Gallen Breast Cancer Conference on early-stage breast cancer.

Key words

early breast cancer - therapy decisions - expert panel

Full Text

References

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