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Planta Med 2021; 87(10/11): 764-779
DOI: 10.1055/a-1495-9785
Biological and Pharmacological Activity
Reviews

Pharmacognostic Evaluation of Ten Species of Medicinal Importance of Cecropia: Current Knowledge and Therapeutic Perspectives[ # ]

Andrés Rivera-Mondragón
1   Centre of Innovation and Technology Transfer, Institute of Scientific Research and High Technology Services (INDICASAT-AIP), Republic of Panama
,
Orlando O. Ortíz
2   Herbario PMA, University of Panama, Republic of Panama
,
Mahabir P. Gupta†   *
3   Center for Pharmacognostic Research on Panamanian Flora (CIFLORPAN), College of Pharmacy, University of Panama, Republic of Panama
,
Catherina Caballero-George 
1   Centre of Innovation and Technology Transfer, Institute of Scientific Research and High Technology Services (INDICASAT-AIP), Republic of Panama
› Author AffiliationsSupported by: Institute for Scientific Research and High Technology Services CC02-2020
Supported by: Secretaría Nacional de Ciencia, Tecnología e Innovación FID14-116
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Abstract

This work covers a systematic review of literature about the genus Cecropia from 1978 to 2020, emphasizing the analysis of 10 of the most relevant species and their associated biological activities. Cecropia is a neotropical genus, which comprises about 61 native species in the American continent where it is known to be part of the traditional medicine of numerous countries. Secondary metabolites described for this genus showed an elevated structural and functional diversity, where polyphenols have been the most abundant. Based on this diversity, Cecropia phytochemicals represent an important source of potential therapeutic agents yet to be exploited. This review also highlights the effectiveness of combining chemometrics and ultra-performance liquid chromatography-tandem mass spectrometry as a novel approach to successfully single out Cecropia species phytochemicals. While the medicinal use of Cecropia species is officially recognized in National Pharmacopoeias and Formularies of several Latin American countries, it is important to recognize that these phytomedicines are complex mixtures requiring a thorough understanding of their chemical composition and their correlation with biological activities to guarantee their quality, safety, and efficacy.

Key words

Urticaceae - Cecropia - diabetes - hypertension - flavonoids C-glycosides - ethnobotany

# Dedicated to Professor Arnold Vlietinck on the occasion of his 80th birthday.


* Prof. Dr. Mahabir P. Gupta passed away on December 14, 2020.


Supporting Information

    Table 1S provides the key morphological characteristics of the genus Cecropia. Additionally, Tables 2S, 3S, and 4S show detailed content of chemicals present in the 10 species of Cecropia, selected for this review. Finally, Table 5S summarizes the most relevant pharmacological activities of this genus.

  • Supporting Information


Publication History

Received: 11 January 2021

Accepted after revision: 04 May 2021

Article published online:
20 July 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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