Copper/Di-tert-butyl Peroxide-Catalyzed Regioselective Hydroxyphosphorylation of 1,3-Enynes

Abstract

The copper/di-tert-butyl peroxide-catalyzed regioselective hydroxyphosphorylation of 1,3-enynes is described. The advantages of the reported radical reactions are excellent functional group tolerance, the use of a catalytic amount of copper and di-tert-butyl peroxide ( ^t BuOO ^t Bu) as a radical initiator, and mild reaction conditions. The desired products are obtained in moderate to excellent yields after purification.

Key words

copper catalysis - regioselectivity - radicals - hydroxyphosphorylation - 1,3-enynes

• References

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