Chromium-Catalyzed Reductive Cleavage of Unactivated Aromatic and Benzylic C–O Bonds

This work is dedicated to Professor Shinji Murai for his contribution to bond activation.

Abstract

Reductive cleavage of aromatic and benzylic C–O bonds by chromium catalysis is reported. This deoxygenative reaction was promoted by low-cost CrCl₂ precatalyst combined with poly(methyl hydrogen siloxane) as the mild reducing agent, providing a strategy in forming reduced motifs by cleavage of unactivated C–O bonds. A range of functional groups such as bromide, chloride, fluoride, hydroxyl, amino, and alkoxycarbonyl can be retained in the reduction.

Keywords

C–O bond - reduction - chromium - homogeneous catalysis

Publikationsverlauf

Eingereicht: 24. April 2021

Angenommen nach Revision: 12. Mai 2021

Accepted Manuscript online:
12. Mai 2021

Artikel online veröffentlicht:
23. Juni 2021

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