Synthesis 2021; 53(20): 3836-3846
DOI: 10.1055/a-1516-7917
paper

Applications of Ytterbium(II) Reagent as Grignard Reagent and Single-Electron Transfer Reagent in the Synthesis of 3-Substituted 2-Oxindoles

Pengkai Wang
,
Xuyan Cao
,
Songlin Zhang
We gratefully acknowledge the Priority Academic Program Development of Jiangsu Higher Education Institutions, the Scientific and Technologic Infrastructure of Suzhou (No. SZS201207), and the National Natural Science Foundation of China (No. 21072143) for financial support.


Abstract

The use of ytterbium(II) reagent as both nucleophilic reagent and single-electron transfer reagent in the reaction of isatin derivatives with ytterbium(II) reagent is reported. From a synthetic point of view, a general, efficient, and experimentally simple one-pot method for the preparation of 3-substituted 2-oxindoles was developed.

Supporting Information



Publication History

Received: 16 April 2021

Accepted after revision: 25 May 2021

Accepted Manuscript online:
25 May 2021

Article published online:
23 June 2021

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