OP-Journal 2021; 37(03): 226-237
DOI: 10.1055/a-1517-0140
Fachwissen

Versorgung von Kopfverletzungen

Care of Head Injuries
Oscar Torney
,
Peter Vajkoczy

Zusammenfassung

Schädelhirntraumata (SHT) sind weltweit von großer sozioökonimischer Bedeutung. Sie sind die häufigste Ursache für eine langfristige Behinderung, Erwerbsunfähigkeit und Mortalität bei jungen Erwachsenen. Für eine erfolgreiche Behandlung des SHT-Patienten ist die interdisziplinäre Betreuung durch ein spezialisiertes Team von Neuro-, MKG- und Unfallchirurgen, Neuroanästhesisten, Neurointensivmedizinern, Neuroradiologen sowie HNO-Ärzten erforderlich. Pathophysiologisch werden beim SHT primäre und sekundäre Hirnschäden unterschieden. Da sekundäre Schäden potenziell vermeid- oder zumindest limitierbar sind, sind sie das Ziel neuroprotektiver Maßnahmen im intensivstationären Setting und ein Hauptgegenstand der klinischen Forschung. Dem Hirndruckmanagement kommt hierbei eine besondere Bedeutung zu. Unterschiedliche intrakranielle Blutungstypen werden anhand ihrer Ätiologie, ihres Ausbreitungsmusters und des zugrundeliegenden Pathomechanismus differenziert. Die Versorgung von SHT richtet sich nach der Schwere und dem Ausmaß des Traumas und reicht von einer ambulanten/stationären Überwachung bis zur notfallmäßigen Entlastungskraniotomie. Multicenter-Beobachtungsstudien, wie Center-TBI (Europa) oder TRACK-TBI (USA), helfen dabei, Behandlungsalgorithmen stetig zu verbessern und weiterzuentwickeln. Dabei sollten neueste Studienergebnisse eine schnelle Implementierung in internationalen Guidelines finden („living systematic reviews“). Präventiven Maßnahmen fällt zudem eine besondere Bedeutung zu, da sie ein Sicherheitsbewusstsein schaffen und somit behilflich sind, etwaigen schweren Kopfverletzungen vorzubeugen.

Abstract

Traumatic brain injuries (TBIs) are of major socioeconomic importance worldwide and are the most common cause of long-term disability, incapacity and mortality in young adults.
Successful treatment of the TBI patient requires interdisciplinary care by a specialised team of neurosurgeons, maxillofacial surgeons, trauma surgeons, neuroanaesthetists, neurointensivists, neuroradiologists and ENT physicians.
A distinction is made pathophysiologically between primary and secondary brain damage in TBI. Since secondary damage is potentially preventable or at least limitable, the principle objectives of neuroprotective measures in the intensive care setting and in clinical research are to limit secondary damage. Intracranial pressure management is of particular importance in this context.
Different types of intracranial haemorrhage are differentiated according to their aetiology, their pattern of spread and the underlying pathomechanism. The management of TBIs depends on the severity and extent of the trauma and ranges from outpatient/inpatient monitoring to emergency relieving craniotomy.
Multicentre observational studies, such as Center-TBI (Europe) or TRACK-TBI (USA), help to continuously improve and develop treatment algorithms. The latest study results should be rapidly implemented in international guidelines ("living systematic reviews"). Preventive measures are also of particular importance, as they create safety awareness and thus help to prevent possible serious head injuries.



Publication History

Article published online:
15 November 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Center for TBI. Traumatic Brain Injury. Fact sheets and Policy brief. Im Internet (Stand: 28.06.2021): https://www.center-tbi.eu/files/news/21571f81-20b8-4860-a3dd-1f6e27d02b3d.pdf
  • 2 Hackenberg K, Unterberg A. Schädel-Hirn-Trauma. Nervenarzt 2016; 87: 203-216
  • 3 Rickels E, von Wild K, Wenzlaff P. Head injury in Germany: A population-based prospective study on epidemiology, causes, treatment and outcome of all degrees of head-injury severity in two distinct areas. Brain Inj 2010; 24: 1491-1504
  • 4 Tator CH, Davis HS, Dufort PA. et al. Postconcussion syndrome: demographics and predictors in 221 patients. J Neurosurg 2016; 125: 1206-1216
  • 5 McKee AC, Cantu RC, Nowinski CJ. et al. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy following Repetitive Head Injury. J Neuropathol Exp Neurol 2009; 68: 709-735
  • 6 Davis GA, Castellani RJ, McCrory P. Neurodegeneration and Sport. Neurosurgery 2015; 76: 643-656
  • 7 Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974; 2: 81-84
  • 8 Reilly PL, Graham DI, Adams JH. et al. Patients with head injury who talk and die. Lancet 1975; 2: 375-377
  • 9 Stocchetti N, Carbonara M, Citerio G. et al. Severe traumatic brain injury: targeted management in the intensive care unit. Lancet Neurol 2017; 16: 452-464
  • 10 Greenberg MS. Handbook of Neurosurgery. 8th ed.. Stuttgart: Thieme; 2016: 824
  • 11 TraumaRegister DGU®. Schädel-Hirn-TraumaModul TraumaRegister DGU. Im Internet (Stand: 28.06.2021): https://schaedel-hirn-traumamodul.auc-online.de
  • 12 CENTER-TBI. A few facts about TBI. Im Internet (Stand: 28.06.2021): https://www.center-tbi.eu
  • 13 Kinoshita K. Traumatic brain injury: pathophysiology for neurocritical care. J Intensive Care 2016; 4: 29
  • 14 Greenberg MS. Handbook of Neurosurgery. 8th ed.. Stuttgart: Thieme; 2016. 824. 841 846
  • 15 Maas AIR, Menon DK, Adelson DP. et al. InTBIR Participants and Investigators. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol 2017; 16: 987-1048
  • 16 Balestreri M, Czosnyka M, Hutchinson P. et al. Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury. Neurocrit Care 2006; 4: 8-13
  • 17 Andrade AF, Paiva WS, Soares MS. et al. Classification and management of mild head trauma. Int J Gen Med 2011; 4: 175-179
  • 18 Firsching R, Rickels E, Mauer UM. et al. S2e-Leitlinie: Schädelhirntrauma im Erwachsenenalter, Update 2015, AWMF-Register Nr. 008/001. Im Internet (Stand: 28.06.2021): https://www.awmf.org/uploads/tx_szleitlinien/008-001l_S2e_Schaedelhirntrauma_SHT_Erwachsene_2015-12-abgelaufen.pdf
  • 19 McMillan T, Wilson L, Ponsford J. et al. The Glasgow Outcome Scale – 40 years of application and refinement. Nat Rev Neurol 2016; 12: 477-485
  • 20 Bullock MR, Chesnut R, Ghajar J. et al. Surgical Management of Traumatic Brain Injury Author Group. Surgical management of traumatic parenchymal lesions. Neurosurgery 2006; 58 (3 Suppl.): S25-S46 discussion Si-iv
  • 21 Greenberg MS. Handbook of Neurosurgery. 8th ed.. Stuttgart: Thieme; 2016: 892
  • 22 Hölper B, Eichler M. Kompendium Neuro- und Wirbelsäulenchirurgie. 3. Aufl.. Rosenheim: proINN; 2012
  • 23 Greenberg MS. Handbook of Neurosurgery. 8th ed.. Stuttgart: Thieme; 2016: 893
  • 24 Kernohan JW, Woltman HW. Incisura of the Crus due to Contralateral Brain Tumor. Arch Neurol Psychiatr 1929; 21: 274-287
  • 25 Bullock MR, Chesnut R, Ghajar J. et al. Surgical Management of Traumatic Brain Injury Author Group. Surgical management of acute epidural hematomas. Neurosurgery 2006; 58 (3 Suppl.): S7-S15 discussion Si-iv
  • 26 Aoki N, Oikawa A, Sakai T. Symptomatic Subacute Subdural Hematoma Associated with Cerebral Hemispheric Swelling and Ischemia. Neurol Res 1996; 18: 145-149
  • 27 Nishio M, Akagi K, Abekura M. et al. [A Case of Traumatic Subacute Subdural Hematoma Presenting Symptoms Arising from Cerebral Hemisphere Edema]. No Shinkei Geka 1998; 26: 425-429
  • 28 Bullock MR, Chesnut R, Ghajar J. et al. Surgical Management of Traumatic Brain Injury Author Group. Surgical management of acute subdural hematomas. Neurosurgery 2006; 58 (3 Suppl.): S16-S24 discussion Si-iv
  • 29 Karibe H, Hayashi T, Hirano T. et al. Surgical management of traumatic acute subdural hematoma in adults: a review. Neurol Med Chir (Tokyo) 2014; 54: 887-894
  • 30 Wilberger jr. JE, Harris M, Diamond DL. Acute subdural hematoma: morbidity, mortality, and operative timing. J Neurosurg 1991; 74: 212-218
  • 31 Cagetti B, Cossu M, Pau A. et al. The outcome from acute subdural and epidural intracranial haematomas in very elderly patients. Br J Neurosurg 1992; 6: 227-231
  • 32 Jamjoom A. Justification for evacuating acute subdural haematomas in patients above the age of 75 years. Injury 1992; 23: 518-520
  • 33 Brainfoundation. Vegetative State. Im Internet (Stand: 28.06.2021): https://brainfoundation.org.au/disorders/vegetative-state/
  • 34 Zumkeller M, Behrmann R, Heissler HE. et al. Computed tomographic criteria and survival rate for patients with acute subdural hematoma. Neurosurgery 1996; 39: 708-712 discussion 712–713
  • 35 Munro D, Merritt HH. Surgical Pathology of Subdural Hematoma: Based on a Study of One Hundred and Five Cases. Arch Neurol Psychiatry 1936; 35: 64-78
  • 36 Jaeger M, Meixensberger J. Die traumatische Subarachnoidalblutung und ihre klinische Relevanz. Intensivmed 2004; 41: 148-152
  • 37 Greenberg MS. Handbook of Neurosurgery. 8th ed.. Stuttgart: Thieme; 2016: 832
  • 38 Tian HL, Xu T, Hu J. et al. Risk factors related to hydrocephalus after traumatic subarachnoid hemorrhage. Surg Neurol 2008; 69: 241-246 discussion 246
  • 39 Vergouwen MDI, Vermeulen M, Roos YBWEM. Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic review. Lancet Neurol 2006; 5: 1029-1032
  • 40 Servadei F, Nasi MT, Giuliani G. et al. CT prognostic factors in acute subdural haematomas: the value of the ‘worst’ CT scan. Br J Neurosurg 2000; 14: 110-116
  • 41 Povlishock JT, Christman CW. The pathobiology of traumatically induced axonal injury in animals and humans: a review of current thoughts. J Neurotrauma 1995; 12: 555-564
  • 42 Mesfin FB, Gupta N, Shapshak AH. et al. Diffuse Axonal Injury. In: StatPearls [Internet] Treasure Island; 2021
  • 43 Alahmadi H, Vachhrajani S, Cusimano MD. The natural history of brain contusion: an analysis of radiological and clinical progression. J Neurosurg 2010; 112: 1139-1145
  • 44 Alali AS, Fowler RA, Mainprize TG. et al. Intracranial pressure monitoring in severe traumatic brain injury: results from the American College of Surgeons Trauma Quality Improvement Program. J Neurotrauma 2013; 30: 1737-1746
  • 45 Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology 2001; 56: 1746-1748
  • 46 Huttner HB. Intrakranieller Druck (ICP), S1-Leitlinie, 2018. In: Deutsche Gesellschaft für Neurologie, Hrsg. Leitlinien für Diagnostik und Therapie in der Neurologie. Im Internet (Stand: 28.06.2021): http://www.dgn.org/leitlinien/ll-030-105-2018-intrakranieller-druck-icp/
  • 47 Chesnut RM, Temkin N, Carney N. et al. A trial of intracranial-pressure monitoring in traumatic brain injury. N Engl J Med 2012; 367: 2471-2481
  • 48 Sahuquillo J, Dennis JA. Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury. Cochrane Database Syst Rev 2019; (12) CD003983
  • 49 Okonkwo DO, Shutter LA, Moore C. et al. Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial. Crit Care Med 2017; 45: 1907-1914
  • 50 Czosnyka M, Smielewski P, Timofeev I. et al. Intracranial pressure: more than a number. Neurosurg Focus 2007; 22: E10
  • 51 Zeiler FA, Beqiri E, Cabeleira M. et al. Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Exploratory Analysis of Insult Burden. J Neurotrauma 2020; 37: 1854-1863
  • 52 Chesnut R, Aguilera S, Buki A. et al. A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Intensive Care Med 2020; 46: 919-929
  • 53 Cooper DJ, Nichol AD, Bailey M. et al. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. JAMA 2018; 320: 2211-2220
  • 54 Andrews PJ, Sinclair HL, Rodriguez A. et al. Eurotherm3235 Trial Collaborators. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury. N Engl J Med 2015; 373: 2403-2412
  • 55 Carney N, Totten AM, OʼReilly C. et al. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Neurosurgery 2017; 80: 6-15
  • 56 Brain Trauma Foundation; American Association of Neurological Surgeons; Congress of Neurological Surgeons; Joint Section on Neurotrauma and Critical Care, AANS/CNS. Bratton SL, Chestnut RM, Ghajar J. et al. Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. J Neurotrauma 2007; 24 (Suppl. 01) S7-S13
  • 57 The CRASH trial management group, The CRASH trial collaborators. The CRASH trial protocol (Corticosteroid randomisation after significant head injury) [ISRCTN74459797]. BMC Emerg Med 2001; 1: 1
  • 58 Roberts I, Shakur H, Coats T. et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess 2013; 17: 1-79
  • 59 CRASH-3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 2019; 394: 1713-1723
  • 60 Horsley V. Address in Surgery: Delivered at the seventy-fourth annual meeting of the British Medical Association. Br Med J 1906; 2: 411-423
  • 61 Cushing H. Technical methods of performing certain cranial operations. Surg Gynecol Obstet 1908; 3: 227-246
  • 62 Cooper DJ, Rosenfeld JV, Murray L. et al. DECRA Trial Investigators, Australian and New Zealand Intensive Care Society Clinical Trials Group. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med 2011; 364: 1493-1502
  • 63 Hutchinson PJ, Kolias AG, Timofeev IS. et al. RESCUEicp Trial Collaborators. Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension. N Engl J Med 2016; 375: 1119-1130
  • 64 Rauen K, Reichelt L, Probst P. et al. Decompressive Craniectomy Is Associated With Good Quality of Life Up to 10 Years After Rehabilitation From Traumatic Brain Injury. Crit Care Med 2020; 48: 1157-1164
  • 65 Hutchinson PJ, Kolias AG, Tajsic T. et al. Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury: Consensus statement. Acta Neurochir (Wien) 2019; 161: 1261-1274
  • 66 Kolias AG, Viaroli E, Rubiano AM. et al. The current status of decompressive craniectomy in traumatic brain injury. Curr Trauma Rep 2018; 4: 326-332
  • 67 Janatpour ZC, Szuflita NS, Spinelli J. et al. Inadequate Decompressive Craniectomy Following a Wartime Traumatic Brain Injury – An Illustrative Case of Why Size Matters. Military Med 2019; 184: 929-933
  • 68 Honeybul S, Morrison DA, Ho KM. et al. A randomised controlled trial comparing autologous cranioplasty with custom-made titanium cranioplasty: long-term follow-up. Acta Neurochir (Wien) 2018; 160: 885-891
  • 69 Honeybul S, Morrison DA, Ho KM. et al. A randomized controlled trial comparing autologous cranioplasty with custom-made titanium cranioplasty. J Neurosurg 2017; 126: 81-90