Synlett 2021; 32(12): 1227-1230
DOI: 10.1055/a-1520-9916
letter

Green Aerobic Oxidation of Thiols to Disulfides by Flavin–Iodine Coupled Organocatalysis

Marina Oka
,
Ryo Kozako
,
Hiroki Iida
This work was supported in part by JSPS/MEXT KAKENHI [Grant-in-Aid for Scientific Research (C), No. 19K05617] and by the Electric Technology Research Foundation of Chugoku.


Abstract

Coupled catalysis using a riboflavin-derived organocatalyst and molecular iodine successfully promoted the aerobic oxidation of thiols to disulfides under metal-free mild conditions. The activation of molecular oxygen occurred smoothly at room temperature through the transfer of electrons from the iodine catalyst to the biomimetic flavin catalyst, forming the basis for a green oxidative synthesis of disulfides from thiols.

Supporting Information



Publikationsverlauf

Eingereicht: 22. April 2021

Angenommen: 31. Mai 2021

Accepted Manuscript online:
31. Mai 2021

Artikel online veröffentlicht:
14. Juni 2021

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