Cobalt-Catalyzed Oxidative [4+2] Annulation of Benzamides with Dihydrofuran: A Facile Route to Tetrahydrofuro[2,3-c]isoquinolinones

Abstract

A cobalt-catalyzed oxidative [4+2] annulation of benz­amides with dihydrofuran was developed for the expeditious synthesis of tetrahydrofuro[2,3-c]isoquinolinones. Commercially available and inexpensive Co(OAc)₂·4H₂O was used as an efficient catalyst. Various functional groups were tolerated, affording the desired products in good yields with excellent regioselectivity and good diastereoselectivity under mild conditions.

Key words

cobalt - oxidative annulations - C–H activation - tetrahydrofuro[2,3-c]isoquinolinone - dihydrofuran

Publication History

Received: 08 May 2021

Accepted after revision: 01 June 2021

Accepted Manuscript online:
01 June 2021

Article published online:
24 June 2021

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