kleintier konkret, Table of Contents kleintier konkret 2021; 24(04): 46-57DOI: 10.1055/a-1522-4019 Innere Medizin Therapie und Monitoring von Cushing-Patienten – Routine oder Herausforderung? Authors Julia Kinny-Köster Jennifer von Luckner Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Der Hyperadrenokortizismus gehört zu den häufigen endokrinologischen Erkrankungen des älteren Hundes. Immer wieder gibt es Unklarheiten bezüglich Art der Therapie, Therapieeinstellung und Monitoring. Diesen Fragen soll hier gemäß dem aktuellen Stand der Wissenschaft nachgegangen werden. Full Text References Literatur 1 Pérez-Alenza D, Melián C. Hyperadrenocorticism in Dogs. In: Ettinger SJ, Feldman EC, Côté E. Textbook of Veterinary Internal Medicine. St. Louis: Elsevier; 2017 2 Behrend EN. et al. Diagnosis of spontaneous canine hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal). J Vet Intern Med 2013; 27: 1292-1304 3 Nagata N, Kojima K, Yuki M. Comparison of survival times for dogs with pituitary-dependent hyperadrenocorticisim in a primary-care hospital: treated with trilostane versus untreated. J Vet Intern Med 2017; 31: 22-28 4 Behrend EN. Canine Hyperadrenocorticism. In: Feldman EC. et al., Hrsg. Canine & Feline Endocrinology. St. Louis: Elsevier; 2015 5 Ferguson DC, Peterson ME. Serum free and total iodothyronine concentrations in dogs with hyperadrenocorticism. Am J Vet Res 1992; 53 (09) 1636-1640 6 Kenefick SJ, Neiger R. The effect of trilostane treatment on circulating thyroid hormone concentrations in dogs with pituitary-dependent hyperadrenocorticism. J Small Anim Pract 2008; 49 (03) 139-143 7 McLauchlan G. et al. Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism. J Small Anim Pract 2010; 52: 642-648 8 Park FM. et al. Hypercoagulability and ACTH-dependent hyperadrenocorticism in dogs. J Vet Intern Med 2013; 27: 1136-1142 9 Mawby DI, Whittemore JC, Fecteau KA. Canine pancreatic-specific lipase concentrations in clinically healthy dogs and dogs with naturally occurring hyperadrenocorticism. J Vet Intern Med 2014; 28: 1244-1250 10 Ramsey I. Monitoring treatment in canine hyperadrenocorticism. BSAVA Congress Proceedings. 2019 11 Barker EN. et al. A comparison of the survival times of dogs Treated with Mitotane or Trilostane for Pituitary-Dependent Hyperadrenocorticism. J Vet Intern Med 2005; 19: 810-815 12 Clemente M. et al. Comparison of non-selective adrenocorticolysis with mitotane or trilostane for the treatment of dogs with pituitary-dependent hyperadrenocorticism. Vet Rec 2007; 161 (24) 805-809 13 Lemetayer J, Blois S. Update on the use of trilostane in dogs. Can Vet J 2018; 59: 397-407 14 Neiger R, Lehnert C. Treatment of canine hyperadrenocorticism (Cushingʼs disease) with trilostane. Tierärtzl Prax K H 2004; 32: 193-198 15 Feldman EC, Kass PH. Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J Vet Intern Med 2012; 26: 1078-1080 16 Foster S. et al. Efficacy and safety of tightly controlled hyperadrenocorticism in dogs treated with trilostane in general practice. J Vet Intern Med 2020; 34: 3058-3166 17 Arenas Bermejo C. et al. Laboratory assessment of trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med 2020; 34: 1413-1422 18 Arenas C, Melián C, Pérez-Alenza MD. Evaluation of 2 trilostane protocols for the treatment of canine pituitary-dependent hyperadrenocorticism: twice daily versus once daily. J Vet Intern Med 2013; 27: 1478-1485 19 San José PG. et al. Changes in systolic blood pressure in dogs with pituitary dependent hyperadrenocorticism during the first year of trilostane treatment. J Vet Intern Med 2021; 35: 130-141 20 King JB, Morton JM. Incidence and risk factors for hypoadrenocorticism in dogs treated with trilostane. Vet J 2017; 24-29 21 Bermejo CA. et al. Laboratory assessment of trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med 2020; 34: 1413-1422 22 Griebsch C. et al. Effect of trilostane on hormone and serum electrolyte concentrations in Dogs with Pituitary-Dependent Hyperadrenocorticism. J Vet Int Med 2014; 28: 160-165 23 Burkhardt WA. et al. Adrenocorticotropic hormone, but not trilostane, causes severe adrenal hemorrhage, vacuolization, and apoptosis in rats. Domest Anim Endocrinol 2011; 40: 155-164 24 Macfarlane L, Parkin T, Ramsey I. Pre-trilostane and three-hour post-trilostane cortisol to monitor trilostane therapy in dogs. Vet Record 2016. 25 Midence JN, Drobatz KJ, Hess RS. Cortisol concentration in well-regulated dogs with hyperadrenocorticism treated with trilostane. J Vet Intern Med 2015; 29: 1529-1533 26 van Rijn SJ. et al. The influence of pituitary size on outcome after transphenoidal hypophysectomy in a large cohort of dogs with pituitary-dependent hypercortisolism. J Vet Intern Med 2016; 30: 989-995 27 Hanson JM. et al. Efficacy of transsphenoidal hypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism. J Vet Intern Med 2005; 19: 687-694 28 Meij BP. Hypophysectomy as a treatment for canine and feline cushingʼs disease. Vet Clin North Am Small Anim Pract 2001; 31: 1015-1041 29 Arenas C, Melián C, Pérez-Alenza MD. Long-term survival of dogs with adrenal-dependent hyperadrenocorticism: a comparison between mitotane and twice daily trilostane treatment. J Vet Intern Med 2014; 28: 473-480 30 Miceli DD, Pignataro OP, Castillo VA. Concurrent hyperadrenocorticism and diabetes mellitus in dogs. Res Vet Sci 2017; 115: 425-431