Intrahepatic Cholestasis of Pregnancy

Stanisław M. Jurk; Andreas E. Kremer; Ekkehard Schleussner

doi:10.1055/a-1522-5178

Geburtshilfe und Frauenheilkunde, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2021; 81(08): 940-947
DOI: 10.1055/a-1522-5178

GebFra Science

Review/Übersicht

Intrahepatic Cholestasis of Pregnancy

Artikel in mehreren Sprachen: English | deutsch

Authors

Stanisław M. Jurk

¹Leipzig, Germany
Andreas E. Kremer

²Medizinische Klinik 1, Universitätsklinikum Erlangen, Erlangen, Germany

³Klinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich, Zürich, Switzerland
Ekkehard Schleussner

⁴Klinik für Geburtsmedizin, Universitätsklinikum Jena, Jena, Germany

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a predictor for poor perinatal outcome including intrauterine death. Ursodeoxycholic acid (UDCA) has become established as the treatment of choice in clinical management to achieve a significant improvement in symptoms and reduce the cholestasis. Pregnant women with severe intrahepatic cholestasis should always be managed in a perinatal centre with close interdisciplinary monitoring and treatment involving perinatologists and hepatologists to minimise the markedly increased perinatal morbidity and mortality as well as maternal symptoms.

Key words

cholestasis of pregnancy - pruritus - bile acids - antenatal care - induction of labor - fetal death

Volltext

Referenzen

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