Synthesis, Antimicrobial Evaluation of Substituted Indole and
                    Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal
                    Complexes

Preeti Sharma; Varun Kumar Singh; Gajendra Kumar

doi:10.1055/a-1527-1307

Drug Research, Table of Contents

Drug Res (Stuttg) 2021; 71(08): 455-461
DOI: 10.1055/a-1527-1307

Original Article

Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Preeti Sharma

¹Department of Chemistry, Bhagwant University, Ajmer Rajasthan, India

,

Varun Kumar Singh

²Department of Chemistry, FoE, Teerthanker Mahaveer University, Moradabad Uttar Pradesh, India

,

Gajendra Kumar

²Department of Chemistry, FoE, Teerthanker Mahaveer University, Moradabad Uttar Pradesh, India

› Author Affiliations

Abstract

Schiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine was synthesized by the condensation of 1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at 70 ^oC. The prepared Schiff base ligand doped with Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as [M(C₃₄H₃₂N₈O₄)X]X₂. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, ¹H NMR, ¹³C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometry of the metal center was five coordinate square pyramidal. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential against Staphylococcus aureus, Bacillus subtilis (positive bacteria) and Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi (negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium sp. [Cr(C₃₄H₃₂N₈O₄)OAc](OAc)₂ shows best antimicrobial activity against all the pathogens.

Key words

Schiff base - Metal complexes - Antimicrobial activity - Spectroscopic study

Full Text

References

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