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DOI: 10.1055/a-1534-0466
Elemental Sulfur Mediated Synthesis of Pyrrolo[1,2-a]quinoxalines from 1-(2-Nitroaryl)pyrroles
We thank the Viet Nam National University Ho Chi Minh City (VNU-HCM) for financial support via project no. NCM2019-20-01 (for N.T.S.P.).
Abstract
Methods to afford pyrrolo[1,2-a]quinoxalines often require the use of prefunctionalized aniline precursors, transition metals, and/or harsh conditions. Herein we describe a simple coupling of 1-(2-nitroaryl)pyrroles and arylacetic acids, in the presence of elemental sulfur, to furnish the fused heterocycles in good yields. The conditions are compatible with many functionalities including ester, nitrile, halogen, and nitro groups. Use of benzyl alcohols and picoline coupling reagents was also attempted.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1534-0466.
- Supporting Information
Publikationsverlauf
Eingereicht: 21. Mai 2021
Angenommen nach Revision: 22. Juni 2021
Accepted Manuscript online:
22. Juni 2021
Artikel online veröffentlicht:
22. Juli 2021
© 2021. Thieme. All rights reserved
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