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Synthesis 2021; 53(21): 4079-4085
DOI: 10.1055/a-1542-4258
DOI: 10.1055/a-1542-4258
paper
Synthesis of (Hetero)Aryl-Functionalized Azaindoline Derivatives by Palladium-Catalyzed Domino Heck Cyclization/Hiyama Cross-Coupling
The generous financial support from the Program of High-Level Talents of Nantong University (03083031) is gratefully acknowledged.
Abstract
A palladium-catalyzed domino Heck cyclization/Hiyama cross-coupling has been achieved for the synthesis of (hetero)aryl-functionalized azaindoline derivatives bearing all-carbon quaternary centers in 46–85% yields. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and modification of aryl-containing complex bioactive molecules.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1542-4258.
- Supporting Information
Publication History
Received: 24 May 2021
Accepted after revision: 01 July 2021
Accepted Manuscript online:
01 July 2021
Article published online:
22 July 2021
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For selected examples, see:
For selected reviews on Hiyama cross-coupling, see:
For selected examples and references therein, see: