CC BY-NC-ND 4.0 · Planta Medica International Open 2021; 8(03): e114-e121 DOI: 10.1055/a-1543-1261
Original Papers
Triterpenoids from Alisma orientale and their NF-кB Inhibitory Activity
Qian Yang
1
State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4
Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
,
Yinqing Li
2
Shineway Pharmaceutical Group Ltd., Shijiazhuang, PR China
3
Hebei key Laboratory of Famous Classical Formulas and TCM Quality Process Control, Shijiazhuang, PR China
,
Xizi Liu
1
State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4
Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
,
Shiyi Han
1
State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4
Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
,
Siyang Fan
1
State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China
4
Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China
› InstitutsangabenFunding
This work was supported by grants from the National Natural Science
Foundation of China (No. 81603279), the National Science
and Technology Project of China (No. 2018ZX09731–016), and the
S&T Program of Hebei (20272502D).
The rhizome of Alisma orientale (sam.) Juz. is used in clinics for eliminating dampness, reducing edema, and promoting diuresis. This study aimed to elucidate the compounds and investigate their nuclear factor-kappa inhibitory activities in human embryonic kidney 293 cells. A new triterpene, alismaketone B (1); a new natural nortriterpene, noralisolic acid A (2); and 13 known protostane-type triterpenes were isolated from the rhizome of A. orientale. The new structures and their absolute configurations were established using HRESIMS, NMR, and electronic circular dichroism experiments. All isolated compounds were evaluated for their inhibitory activity on NF-κB. The compounds 8, 9, 10, and 14 showed moderate NF-κB inhibitory activities with their IC50 values being 64.7, 32.3, 47.3, and 37.3 μM, respectively.
Key words
Alisma orientale -
Alismataceae -
triterpenoids -
nuclear factor-kappa B
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