Administration of Antenatal Corticosteroids: Current State of Knowledge

Richard Berger; Ioannis Kyvernitakis; Holger Maul

doi:10.1055/a-1555-3444

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(03): 287-296
DOI: 10.1055/a-1555-3444

GebFra Science

Review/Übersicht

Applikation antenataler Kortikosteroide: aktueller Wissensstand

Article in several languages: English | deutsch

Richard Berger

¹Marienhaus Klinikum St. Elisabeth, Klinik für Gynäkologie und Geburtshilfe, Neuwied, Germany

,

Ioannis Kyvernitakis

²Asklepios Kliniken Barmbek, Wandsbek und Nord-Heidberg, Frauenkliniken, Hamburg, Germany

,

Holger Maul

²Asklepios Kliniken Barmbek, Wandsbek und Nord-Heidberg, Frauenkliniken, Hamburg, Germany

› Author Affiliations

Abstract

Zusammenfassung

Die einmalige Gabe von Kortikosteroiden vor 34 + 0 SSW bei drohender Frühgeburt ist ein Standard in der heutigen Geburtshilfe und in den Leitlinien der verschiedensten Länder fest verankert. Trotz der anscheinend überzeugenden Datenlage sind allerdings zahlreiche Teilaspekte zu dieser Intervention nur wenig geklärt. So war bisher offen, welches Kortikosteroid die optimale Wirkung erzielt. Es gibt kaum Studien zur Dosierung, zur zirkadianen Rhythmik, zum Zeitfenster der Wirksamkeit oder zur Nutzen-Schaden-Bilanz einer wiederholten Gabe. Da in den vorliegenden Studien selten Patientinnen vor 24 + 0 SSW eingeschlossen wurden, haben wir nur wenig Information zum möglichen Nutzen einer Kortikosteroid-Applikation vor diesem Zeitpunkt. Bei einer antenatalen Gabe von Kortikosteroiden nach 34 + 0 SSW stehen dem kurzfristigen Nutzen möglicherweise langfristige Beeinträchtigungen in der psychomotorischen Entwicklung gegenüber. Die vorliegende Arbeit fasst den derzeitigen Wissensstand zu diesen Fragen zusammen.

Schlüsselwörter

Kortikosteroide - Frühgeburt - Dosis - Timing

Full Text

References

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