HMPA-Free Generation of Trialkylsilyllithium Reagents and Its Applications to the Synthesis of Silylboronic Esters

Abstract

Trialkylsilyllithium species have turned out to be facilely generated by treating hexaalkyldisilanes with methyllithium in the presence of tris(N,N-tetramethylene)phosphoric triamide (TPPA) as an activator, which can be trapped by boron electrophiles to afford silylboronic esters including long-awaited Me₃Si–B(pin).

Key words

trialkylsilyllithium - hexaalkyldisilane - silylboronic ester - TPPA­ - HMPA

Publication History

Received: 08 July 2021

Accepted after revision: 26 July 2021

Accepted Manuscript online:
26 July 2021

Article published online:
23 August 2021

• References


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