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Synlett 2021; 32(17): 1741-1746
DOI: 10.1055/a-1581-2345
DOI: 10.1055/a-1581-2345
letter
Asymmetric Synthesis of 3-Phenyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carbonitriles Catalyzed by Phase-Transfer Catalyst Derived from tert-Leucine
We thank the financial support from the National Natural Science Foundation of China (Grant No. 51373067).
Abstract
Chiral phase-transfer catalysts derived from tert-leucine were synthesized and used in the asymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers of the corresponding products were obtained in excellent yield (up to 99%) with high enantioselectivities (up to 91% ee) and diastereoselectivities (up to >99: 1 dr).
Key words
tert-leucine - 4-azaindolines - phase-transfer catalyst - enantiomers - intramolecular Mannich reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1581-2345.
- Supporting Information
Publication History
Received: 24 March 2021
Accepted after revision: 09 August 2021
Accepted Manuscript online:
09 August 2021
Article published online:
24 August 2021
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