Drug Research, Table of Contents Drug Res (Stuttg) 2021; 71(S 01): S13-S14DOI: 10.1055/a-1606-5609 Extended Abstract Nukleäre Rezeptoren beim hepatischen und intestinalen Medikamententransport Gerd A. Kullak-Ublick Recommend Article Abstract Full Text References Literatur 1 Kullak-Ublick GA, Jung D, Meier PJ. [Role of nuclear receptors in hepatic and intestinal drug transport]. Dtsch Med Wochenschr 2003; 128: 389-393 2 Chawla A, Repa JJ, Evans RM. et al. Nuclear receptors and lipid physiology: opening the X-files. Science 2001; 294: 1866-1870 3 Amacher DE. The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors. Expert Opin Drug Metab Toxicol 2016; 12: 1463-1477 4 Kullak-Ublick GA, Ismair MG, Stieger B. et al. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 2001; 120: 525-533 5 Greiner B, Eichelbaum M, Fritz P. et al. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest 1999; 104: 147-153 6 Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996; 49: 311-318 7 Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001; 276: 14581-14587 8 Eloranta JJ, Meier PJ, Kullak-Ublick GA. Coordinate transcriptional regulation of transport and metabolism. Methods Enzymol 2005; 400: 511-530 9 Liddle C, Goodwin B. Regulation of hepatic drug metabolism: role of the nuclear receptors PXR and CAR. Semin Liver Dis 2002; 22: 115-122 10 Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001; 7: 584-590 11 Staudinger JL, Woody S, Sun M. et al. Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver. Drug Metab Rev 2013; 45: 48-59 12 Tocchetti GN, Rigalli JP, Arana MR. et al. Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics. Toxicol Appl Pharmacol 2016; 303: 45-57 13 Guo GL, Lambert G, Negishi M. et al. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem 2003; 278: 45062-45071 14 Ismair MG, Stieger B, Cattori V. et al. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 2001; 121: 1185-1190 15 Jung D, Podvinec M, Meyer UA. et al. Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 2002; 122: 1954-1966 16 Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 2004; 126: 322-342 17 Kjaergaard K, Frisch K, Sorensen M. et al. Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis. J Hepatol 2021; 74: 58-65 18 Landrier JF, Eloranta JJ, Vavricka SR. et al. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol 2006; 290: G476-G485
