Abstract
Purpose We compared the efficacy and safety of beinaglutide, a
glucagon-like peptide-1 (GLP-1) analogue with metformin in lowering the
bodyweight of patients who were overweight/obese and non-diabetic.
Patients and Methods Seventy-eight non-diabetic patients were randomly
selected and beinaglutide or metformin was administered for 12 weeks. The
primary endpoints were changes in body weight and the proportions of patients
who lost≥5 and≥10% of their baseline body weights.
Results A total of 64 patients completed the study; patients in the
beinaglutide group exhibited more bodyweight loss than those in the metformin
group [(9.5±0.8%; 9.1±0.9 kg) and
(5.1±0.9%; 4.5±0.8 kg), respectively,
corresponding to a difference of approximately 4.5 kg (95%
confidence interval, 2.2–6.9 kg; P<0.01)]. In the
beinaglutide group, 90.6 and 40.6% of the patients lost≥5
and≥10% of their body weight, respectively, whereas, in the
metformin group, these rates were 46.9 and 12.5%, respectively
(P<0.01 and P<0.05). Weight loss following
beinaglutide treatment mainly resulted from the loss of fat mass. Compared to
metformin, beinaglutide induced a greater decrease in the body mass index,
weight circumference, percent body fat, and body fat mass (total, trunk, limb,
android, and gynoid). Additionally, beinaglutide decreased serum insulin levels
and ameliorated insulin resistance.
Conclusions Beinaglutide is more efficient than metformin at reducing
weight and fat mass in patients who are overweight/obese and
non-diabetic. Beinaglutide may be a useful therapeutic option for
overweight/obesity control in the Chinese population.
Key words
Glucagon-like peptide-1 receptor agonist - Biguanides - Weight loss ratio - Body composition
