Tierarztl Prax Ausg K Kleintiere Heimtiere 2021; 49(06): 441-454
DOI: 10.1055/a-1640-4123
Übersichtsartikel

Lungenfunktionsmessung bei der Katze – eine Übersicht

Pulmonary function testing in the cat – an overview
Hannah Gareis
Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München
,
Bianka Schulz
Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München
› Author Affiliations

Zusammenfassung

Dieser Artikel bietet eine Übersicht über verfügbare invasive und nicht invasive Lungenfunktionstests bei Katzen. Die invasiven Techniken umfassen die arterielle Blutgasanalyse sowie die Messung der Lungenmechanik. Zu den nicht invasiven Methoden gehören neben der Pulsoxymetrie und Kapnografie auch bisher nicht in den Praxisalltag integrierte Methoden wie tidale Atemfluss-Volumen-Schleifen, barometrische Ganzkörperple-thysmografie und Thoraxkompression. In diesem Artikel werden Hintergründe, Durchführung, Interpretation und Limitationen der einzelnen Tests diskutiert. Bei korrekter Durchführung und Beurteilung der Befunde ermöglichen Lungenfunktionsmessungen, die Pathophysiologie von Atemwegserkrankungen bei Katzen besser zu verstehen und die vorliegende Erkrankung sowie Wirksamkeit einer Therapie objektiver einzuschätzen.

Abstract

This article provides an overview of currently available pulmonary function tests in cats, divided into invasive and non-invasive methods. Invasive techniques comprise arterial blood gas analysis and measurement of pulmonary mechanics. Non-invasive techniques include pulse oximetry and capnography, as well as methods not yet integrated into everyday practice such as tidal breathing airflow-volume loops, whole-body barometric plethysmography and thorax compression. In this article, the background, execution, interpretation, and limitations of each test are discussed. Proper performance and assessment of pulmonary function measurements may aid in understanding the pathophysiology of feline respiratory disease and in increasing objectivity when assessing the existing disease and treatment efficacy.

Zusatzmaterial



Publication History

Received: 15 June 2021

Accepted: 06 September 2021

Article published online:
03 December 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Rozanski EA, Hoffman AM. Pulmonary function testing in small animals. Clin Tech Small Anim Pract 1999; 14: 237-241
  • 2 Hoffman AM. Airway physiology and clinical function testing. Vet Clin North Am Small Anim Pract 2007; 37: 829-843
  • 3 McKiernan BC, Johnson LR. Clinical pulmonary function testing in dogs and cats. Vet Clin North Am Small Anim Pract 1992; 22: 1087-1099
  • 4 Crapo RO. Pulmonary-function testing. N Engl J Med 1994; 331: 25-30
  • 5 Hutchinson J. On the capacity of the lungs, and on the respiratory functions, with a view of establishing a precise and easy method of detecting disease by the spirometer. Med Chir Trans 1846; 29: 137-252
  • 6 Balakrishnan A, Tong CW. Clinical application of pulmonary function testing in small animals. Vet Clin North Am Small Anim Pract 2020; 50: 273-294
  • 7 Padrid P. Pulmonary diagnostics. Vet Clin North Am Small Anim Pract 2000; 30: 1187-1206
  • 8 Bark H, Epstein A, Bar-Yishay E. et al. Non-invasive forced expiratory flow-volume curves to measure lung function in cats. Respir Physiol Neurobiol 2007; 155: 49-54
  • 9 McKiernan BC, Dye JA, Rozanski EA. Tidal breathing flow-volume loops in healthy and bronchitic cats. J Vet Intern Med 1993; 7: 388-393
  • 10 Dye JA, McKiernan BC, Rozanski EA. et al. Bronchopulmonary disease in the cat: historical, physical, radiographic, clinicopathologic, and pulmonary functional evaluation of 24 affected and 15 healthy cats. J Vet Intern Med 1996; 10: 385-400
  • 11 Epstein A, Godfrey S, Bar-Yishay E. et al. Non-invasive measurement of total respiratory compliance and resistance in cats. Respir Physiol Neurobiol 2007; 156: 179-186
  • 12 Padrid P, Snook S, Finucane T. et al. Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats. Am J Respir Crit Care Med 1995; 151: 184-193
  • 13 Norris Reinero CR, Decile KC, Berghaus RD. et al. An experimental model of allergic asthma in cats sensitized to house dust mite or bermuda grass allergen. Int Arch Allergy Immunol 2004; 135: 117-131
  • 14 Reinero CR, Lee-Fowler TM, Dodam JR. et al. Endotracheal nebulization of N-acetylcysteine increases airway resistance in cats with experimental asthma. J Feline Med Surg 2011; 13: 69-73
  • 15 Colebatch HJ, Olsen CR, Nadel JA. Effect of histamine, serotonin, and acetylcholine on the peripheral airways. J Appl Physiol 1966; 21: 217-226
  • 16 Winning AJ, Widdicombe JG. The effect of lung reflexes on the pattern of breathing in cats. Respir Physiol 1976; 27: 253-266
  • 17 Baconnier P, Vahi-Maqueda R, Saetta M. et al. Assessment of induced bronchoconstriction in anesthetized cats by the end-inflation occlusion method. Lung 1989; 167: 149-161
  • 18 Haskins SC. Interpretation of blood gas measurements. In: King LG. ed. Textbook of Respiratory Disease in Dogs and Cats. St. Louis: Elsevier; 2004: 181-193
  • 19 Proulx J. Respiratory monitoring: arterial blood gas analysis, pulse oximetry, and end-tidal carbon dioxide analysis. Clin Tech Small Anim Pract 1999; 14: 227-230
  • 20 Gonzalez AL, Waddell LS. Blood gas analyzers. Top Companion Anim Med 2016; 31: 27-34
  • 21 Ranu H, Wilde M, Madden B. Pulmonary function tests. Ulster Med J 2011; 80: 84-90
  • 22 Robertson SA. Simple acid-base disorders. Vet Clin North Am Small Anim Pract 1989; 19: 289-306
  • 23 Day TK. Blood gas analysis. Vet Clin North Am Small Anim Pract 2002; 32: 1031-1048
  • 24 Haskins S. Blood gases and acid-base balance: clinical interpretation and therapeutic implications. Curr Vet Ther 1983; 8: 201-215
  • 25 Knowles TP, Mullin RA, Hunter JA. et al. Effects of syringe material, sample storage time, and temperature on blood gases and oxygen saturation in arterialized human blood samples. Respir Care 2006; 51: 732-736
  • 26 Shapiro BA, Harrison RA, Walton JR. Clinical Application of Blood Gases. 2nd ed.. Chicago: Year Book Medical Publishers; 1977
  • 27 Madiedo G, Sciacca R, Hause L. Air bubbles and temperature effect on blood gas analysis. J Clin Pathol 1980; 33: 864-867
  • 28 Hansen JE. Arterial blood gases. Clin Chest Med 1989; 10: 227-237
  • 29 Hagley MJ, Hopper K, Epstein SE. Characteristics of arterial catheter use and related complications in dogs and cats in an intensive care unit. J Vet Emerg Crit Care (San Antonio) 2021; 31: 469-475
  • 30 Balakrishnan A, King LG. Updates on pulmonary function testing in small animals. Vet Clin North Am Small Anim Pract 2014; 44: 1-18
  • 31 Shapiro BA. Arterial blood gas monitoring. Crit Care Clin 1988; 4: 479-492
  • 32 West JB, Luks A. West’s Respiratory Physiology: The Essentials. 10th ed.. Philadelphia: Walter Kluwers Health/Lippincott Williams & Wilkins; 2016
  • 33 Dye JA. Feline bronchopulmonary disease. Vet Clin North Am Small Anim Pract 1992; 22: 1187-1201
  • 34 Lee-Fowler TM, Guntur V, Dodam J. et al. The tyrosine kinase inhibitor masitinib blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma. Int Arch Allergy Immunol 2012; 158: 369-374
  • 35 Chang C-H, Dodam JR, Cohn LA. Comparison of direct and indirect bronchoprovocation testing using ventilator-acquired pulmonary mechanics in healthy cats and cats with experimental allergic asthma. Vet J 2013; 198: 444-449
  • 36 Lin CH, Lee JJ, Liu CH. Functional assessment of expiratory flow pattern in feline lower airway disease. J Feline Med Surg 2014; 16: 616-622
  • 37 Reinero CR. Advances in the understanding of pathogenesis, and diagnostics and therapeutics for feline allergic asthma. Vet J 2011; 190: 28-33
  • 38 King LG, Drobatz KJ, Hendricks JC. Static thoracic compliance as a measurement of pulmonary function in dogs. Am J Vet Res 1991; 52: 1597-1601
  • 39 Clark W, Jones B, Clark J. Dynamic pulmonary compliance as a measurement of lung function in dogs. Vet Rec 1977; 101: 497-499
  • 40 Stobie D, Caywood DD, Rozanski EA. et al. Evaluation of pulmonary function and analgesia in dogs after intercostal thoracotomy and use of morphine administered intramuscularly or intrapleurally and bupivacaine administered intrapleurally. Am J Vet Res 1995; 56: 1098-1109
  • 41 Lee-Fowler T, Dodam J, Guntur V. et al. Ventilator-acquired pulmonary mechanics using methacholine challenge in healthy and experimentally asthmatic cats. 27th Symposium of the Veterinary Comparative Respiratory Society. 2009 Plymouth, MA:
  • 42 Rozanski EA, Buckley G, Mazan MR. et al. The effect of tracheal lavage administration on lung function in healthy kittens. J Vet Intern Med 2009; 23: 727
  • 43 Hendricks JC, King LG. Practicality, usefulness, and limits of pulse oximetry in critical small animal patients. J Vet Emerg Crit Care 1993; 3: 5-12
  • 44 Thawley V, Waddell LS. Pulse oximetry and capnometry. Top Companion Anim Med 2013; 28: 124-128
  • 45 Matthews NS, Hartke S, Allen JC. An evaluation of pulse oximeters in dogs, cats and horses. Vet Anaesth Analg 2003; 30: 3-14
  • 46 Ayres DA. Pulse oximetry and CO-oximetry. In: Burkitt Creedon JM, Davis H. eds. Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care. 1st ed.. West Sussex: John Wiley & Sons; 2012: 274-285
  • 47 Nicolai L. Über Sichtbarmachung, Verlauf und chemische Kinetik der Oxyhämoglobinreduktion im lebenden Gewebe, besonders in der menschlichen Haut. Pflügers Arch 1932; 229: 372-384
  • 48 Schnapp LM, Cohen NH. Pulse oximetry. Uses and abuses. Chest 1990; 98: 1244-1250
  • 49 List WF. Pulsoxymetrie. In: List WF, Metzler H, Pasch T. Hrsg. Monitoring in Anästhesie und Intensivmedizin. Berlin, Heidelberg: Springer; 1995: 329-336
  • 50 Duke-Novakovski T. Basics of monitoring equipment. Can Vet J 2017; 58: 1200-1208
  • 51 Grosenbaugh DA, Alben JO, Muir WW. Absorbance spectra of inter-species hemoglobins in the visible and near infrared regions. J Vet Emerg Crit Care 1997; 7: 36-42
  • 52 Mair A, Martinez-Taboada F, Nitzan M. Effect of lingual gauze swab placement on pulse oximeter readings in anaesthetised dogs and cats. Vet Rec 2017; 180: 49
  • 53 Jubran A. Pulse oximetry. Crit Care 1999; 3: 11-17
  • 54 Wukitsch MW, Petterson MT, Tobler DR. et al. Pulse oximetry: analysis of theory, technology, and practice. J Clin Monit 1988; 4: 290-301
  • 55 Jubran A. Pulse oximetry. Crit Care 2015; 19: 272
  • 56 Marino PL. Marino’s The ICU book. 4th ed.. Philadelphia: Walter Kluwers Health/Lippincott Williams & Wilkins; 2007
  • 57 Tepper JS, Costa DL. Methods, measurements, and interpretation of animal lung function in health and disease. In: Comparative Biology of the Normal Lung. 2nd ed.. Amsterdam: Elsevier; 2015: 305-351
  • 58 Fouzas S, Priftis KN, Anthracopoulos MB. Pulse oximetry in pediatric practice. Pediatrics 2011; 128: 740-752
  • 59 Verscheure S, Massion PB, Verschuren F. et al. Volumetric capnography: lessons from the past and current clinical applications. Crit Care 2016; 20: 184
  • 60 Nagler J, Krauss B. Capnography: a valuable tool for airway management. Emerg Med Clin North Am 2008; 26: 881-897
  • 61 Pasch T. Kapnometrie und Kapnographie. In: List WF, Metzler H, Pasch T. Hrsg. Monitoring in Anästhesie und Intensivmedizin. Berlin, Heidelberg: Springer; 1995: 337-366
  • 62 Thompson J, Jaffe MB. Capnographic waveforms in the mechanically ventilated patient. Respir Care 2005; 50: 100-108 discussion 108
  • 63 Marshall M. Capnography in dogs. Compend Contin Educ Pract Vet 2004; 26: 761-777
  • 64 Anderson CT, Breen PH. Carbon dioxide kinetics and capnography during critical care. Crit Care 2000; 4: 207-215
  • 65 Luft K. Über eine neue Methode der registrierenden Gasanalyse mit Hilfe der Absorption ultraroter Strahlen ohne spektrale Zerlegung. Z Tech Phys 1943; 24: 97-104
  • 66 Godwin SA, Caro DA, Wolf SJ. et al. Clinical policy: procedural sedation and analgesia in the emergency department. Ann Emerg Med 2005; 45: 177-196
  • 67 Krauss B, Hess D. Capnography for procedural sedation and analgesia in the emergency department. Ann Emerg Med 2007; 50: 172-181
  • 68 Hart LS, Berns SD, Houck CS. et al. The value of end-tidal CO2 monitoring when comparing three methods of conscious sedation for children undergoing painful procedures in the emergency department. Pediatr Emerg Care 1997; 13: 189-193
  • 69 Johnson PA, Mann FA, Dodam J. et al. Capnographic documentation of nasoesophageal and nasogastric feeding tube placement in dogs. J Vet Emerg Crit Care 2002; 12: 227-233
  • 70 Brainard BM, Boller M, Fletcher DJ. et al. RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 5: Monitoring. J Vet Emerg Crit Care 2012; 22: 65-84
  • 71 Neto FJT, Carregaro AB, Mannarino R. et al. Comparison of a sidestream capnograph and a mainstream capnograph in mechanically ventilated dogs. J Am Vet Med Assoc 2002; 221: 1582-1585
  • 72 Barter LS. Capnography. In: Burkitt Creedon JM, Davis H. eds. Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care. 1st ed.. West Sussex: John Wiley & Sons; 2012: 340-348
  • 73 Hendricks JC, King LG. Practicality, usefulness, and limits of end-tidal carbon dioxide monitoring in critical small animal patients. J Vet Emerg Crit Care 1994; 4: 29-39
  • 74 Raffe MR. End tidal capnography. In: King LG. ed. Textbook of Respiratory Disease in Dogs and Cats. St. Louis: Elsevier; 2004: 198-201
  • 75 Bhavani-Shankar K, Moseley H, Kumar AY. et al. Capnometry and anaesthesia. Can J Anaesth 1992; 39: 617-632
  • 76 Bhavani-Shankar K, Philip JH. Defining segments and phases of a time capnogram. Anesth Analg 2000; 91: 973-977
  • 77 Criée CP, Baur X, Berdel D. et al. Leitlinie zur Spirometrie. Leitlinie der Deutschen Atemwegsliga, der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin und der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin zur Spirometrie. Pneumologie 2015; 69 (03) 147-164
  • 78 Kacmarek RM, Stoller JK, Heuer AJ. Egan’s Fundamentals of Respiratory. 11th ed.. St. Louis, Missouri: Elsevier; 2017
  • 79 Morris JF. Spirometry in the evaluation of pulmonary function. West J Med 1976; 125: 110-118
  • 80 Trzil JE. Feline asthma: diagnostic and treatment update. Vet Clin North Am Small Anim Pract 2020; 50: 375-391
  • 81 Abramson AL, Goldstein MN, Stenzler A. et al. The use of the tidal breathing flow volume loop in laryngotracheal disease of neonates and infants. Laryngoscope 1982; 92: 922-926
  • 82 Amis TC, Kurpershoek C. Tidal breathing flow-volume loop analysis for clinical assessment of airway obstruction in conscious dogs. Am J Vet Res 1986; 47: 1002-1006
  • 83 Amis TC, Smith MM, Gaber CE. et al. Upper airway obstruction in canine laryngeal paralysis. Am J Vet Res 1986; 47: 1007-1010
  • 84 Rozanski EA, Hoffman AM. Lung mechanics using plethysmography and spirometry. In: King LG. ed. Textbook of Respiratory Disease in Dogs and Cats. St. Louis: Elsevier; 2004: 175-181
  • 85 Lin CH, Wu HD, Lee JJ. et al. Functional phenotype and its correlation with therapeutic response and inflammatory type of bronchoalveolar lavage fluid in feline lower airway disease. J Vet Intern Med 2015; 29: 88-96
  • 86 Bernaerts F, Merveille A-C, Bolognin M. et al. Investigation of airway reactivity by barometric whole body plethysmography in cats with spontaneous bronchial disease. 24th Symposium of the Veterinary Comparative Respiratory Society. 2006 Jena, Germany:
  • 87 Rozanski EA, Hoffman AM. Lung function and inhaled albuterol in cats with asthma. J Vet Intern Med 1999; 13: 259
  • 88 Hoffman AM, Dhupa N, Cimetti L. Airway reactivity measured by barometric whole-body plethysmography in healthy cats. Am J Vet Res 1999; 60: 1487-1492
  • 89 Drorbaug JE, Fenn WO. A barometric method for measuring ventilation in newborn infants. Pediatrics 1955; 16: 81-87
  • 90 Mitzner W, Tankersley C. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1998; 158: 340-341
  • 91 Mitzner W, Tankersley C. Interpreting Penh in mice. J Appl Physiol 2003; 94: 828-831 author reply 831–822.
  • 92 Enhorning G, van Schaik S, Lundgren C. et al. Whole-body plethysmography, does it measure tidal volume of small animals?. Can J Physiol Pharmacol 1998; 76: 945-951
  • 93 Hamelmann E, Schwarze J, Takeda K. et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997; 156: 766-775
  • 94 Chand N, Nolan K, Pillar J. et al. Aeroallergen-induced dyspnea in freely moving guinea pigs: quantitative measurement by bias flow ventilated whole body plethysmography. Allergy 1993; 48: 230-235
  • 95 Chong BTY, Agrawal DK, Romero FA. et al. Measurement of bronchoconstriction using whole-body plethysmograph: comparison of freely moving versus restrained guinea pigs. J Pharmacol Toxicol Methods 1998; 39: 163-168
  • 96 Halloy DJ, Kirschvink NA, Vincke GL. et al. Whole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs. Vet J 2004; 168: 276-284
  • 97 Talavera J, Kirschvink N, Schuller S. et al. Evaluation of respiratory function by barometric whole-body plethysmography in healthy dogs. Vet J 2006; 172: 67-77
  • 98 Hirt RA, Leinker S, Mosing M. et al. Comparison of barometric whole body plethysmography and its derived parameter enhanced pause (PENH) with conventional respiratory mechanics in healthy beagle dogs. Vet J 2008; 176: 232-239
  • 99 Hirt RA, Vondrakova K, de Arespacochaga AG. et al. Effects of cadmium chloride inhalation on airflow limitation to histamine, carbachol and adenosine 5′-monophosphate assessed by barometric whole body plethysmography in healthy dogs. Vet J 2007; 173: 62-72
  • 100 Liu NC, Adams VJ, Kalmar L. et al. Whole-body barometric plethysmography characterizes upper airway obstruction in 3 brachycephalic breeds of dogs. J Vet Intern Med 2016; 30: 853-865
  • 101 Liu NC, Sargan DR, Adams VJ. et al. Characterisation of brachycephalic obstructive airway syndrome in french bulldogs using whole-body barometric plethysmography. PLoS One 2015; 10: e0130741
  • 102 Bernaerts F, Talavera J, Leemans J. et al. Description of original endoscopic findings and respiratory functional assessment using barometric whole-body plethysmography in dogs suffering from brachycephalic airway obstruction syndrome. Vet J 2010; 183: 95-102
  • 103 Hirt RA, Dederichs D, Boehler A. et al. Relationship of age, sex, body weight, and hematologic and respiratory variables with airway reactivity in adult cats. Am J Vet Res 2003; 64: 26-31
  • 104 Kirschvink N, Leemans J, Delvaux F. et al. Non-invasive assessment of growth, gender and time of day related changes of respiratory pattern in healthy cats by use of barometric whole body plethysmography. Vet J 2006; 172: 446-454
  • 105 Lin CH, Wu HD, Lo PY. et al. Simultaneous visual inspection for barometric whole-body plethysmography waveforms during pulmonary function testing in client-owned cats. J Feline Med Surg 2016; 18: 761-767
  • 106 Kirschvink N, Leemans J, Delvaux F. et al. Non-invasive assessment of airway responsiveness in healthy and allergen-sensitised cats by use of barometric whole body plethysmography. Vet J 2007; 173: 343-352
  • 107 García-Guasch L, Caro-Vadillo A, Manubens-Grau J. et al. Pulmonary function in obese vs non-obese cats. J Feline Med Surg 2015; 17: 494-499
  • 108 Kirschvink N, Leemans J, Delvaux F. et al. Bronchodilators in bronchoscopy-induced airflow limitation in allergen-sensitized cats. J Vet Intern Med 2005; 19: 161-167
  • 109 Leemans J, Kirschvink N, Clercx C. et al. Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model. Vet J 2012; 192: 41-48
  • 110 Leemans J, Kirschvink N, Bernaerts F. et al. Salmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in cats with experimentally-induced asthma. Vet J 2012; 192: 49-56
  • 111 Kirschvink N, Leemans J, Delvaux F. et al. Functional, inflammatory and morphological characterisation of a cat model of allergic airway inflammation. Vet J 2007; 174: 541-553
  • 112 Allerton FJ, Leemans J, Tual C. et al. Correlation of bronchoalveolar eosinophilic percentage with airway responsiveness in cats with chronic bronchial disease. J Small Anim Pract 2013; 54: 258-264
  • 113 García-Guasch L, Caro-Vadillo A, Laporta M. et al. Barometric whole-body plethysmography reference values in different age-range cats with natural bronchial disease. 18th European College of Veterinary Internal Medicine – Companion Animals Congress. 2008
  • 114 García-Guasch L, Caro-Vadillo A, Manubens-Grau J. et al. Evaluation of pulmonary function variables by using plethysmography in cats with respiratory disease associated to Dirofilaria immitis. Vet Parasitol 2012; 187: 254-258
  • 115 Hirt RA, Galler A, Shibly S. et al. Airway hyperresponsiveness to adenosine 5’-monophosphate in feline chronic inflammatory lower airway disease. Vet J 2011; 187: 54-59
  • 116 Lim R, Zavou MJ, Milton PL. et al. Measuring respiratory function in mice using unrestrained whole-body plethysmography. J Vis Exp 2014; e51755
  • 117 Crièe CP, Berdel D, Heise D. et al. Empfehlungen der Deutschen Atemwegsliga und der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin; Empfehlungen zur Ganzkörperplethysmographie (Bodyplethysmographie). Oberhaching: Dustri; 2009
  • 118 Kirschvink N. Barometric whole body plethysmography and enhanced pause (PENH): How relevant are they?. Vet J 2008; 176: 125-126
  • 119 Data Sciences International. FinePointe™ WBP Application Manual. 2017
  • 120 Kirschvink N, Leemans J, Delvaux F. et al. Inhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis. J Feline Med Surg 2006; 8: 45-54
  • 121 Leemans J, Kirschvink N, Bernaerts F. et al. A pilot study comparing the antispasmodic effects of inhaled salmeterol, salbutamol and ipratropium bromide using different aerosol devices on muscarinic bronchoconstriction in healthy cats. Vet J 2009; 180: 236-245
  • 122 Lundblad LK, Irvin CG, Adler A. et al. A reevaluation of the validity of unrestrained plethysmography in mice. J Appl Physiol 2002; 93: 1198-1207
  • 123 Peták F, Habre W, Donati YR. et al. Hyperoxia-induced changes in mouse lung mechanics: forced oscillations vs. barometric plethysmography. J Appl Physiol 2001; 90: 2221-2230
  • 124 Bates J, Irvin C, Brusasco V. et al. The use and misuse of Penh in animal models of lung disease. Am J Respir Cell Mol Biol 2004; 31: 373-374
  • 125 Lomask M. Further exploration of the Penh parameter. Exp Toxicol Pathol 2006; 57: 13-20
  • 126 van den Hoven R. A jack-in-the-box of respiratory research: Is the technique of barometric whole body plethysmography a disappointing surprise?. Vet J 2007; 173: 250-251
  • 127 Modl M, Eber E, Seifen D. Lungenfunktionsdiagnostik im Säuglingsalter. Thoraxkompressionsmethoden. Monatsschr Kinderheilkd 1998; 146: 1026-1032
  • 128 Taussig LM, Landau LI, Godfrey S. et al. Determinants of forced expiratory flows in newborn infants. J Appl Physiol 1982; 53: 1220-1227
  • 129 Godfrey S, Bar-Yishay E, Arad I. et al. Flow-volume curves in infants with lung disease. Pediatrics 1983; 72: 517-522
  • 130 Stocks J, Sly PD, Tepper RS. et al. Infant respiratory function testing. 1st ed.. New York: John Wiley & Sons; 1996
  • 131 Le Souëf PN, Hughes DM, Landau LI. Shape of forced expiratory flow-volume curves in infants. Am Rev Respir Dis 1988; 138: 590-597