Update S3-Leitlinie Intestinale Motilitätsstörungen: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)

Jutta Keller; Thilo Wedel; Holger Seidl; Martin E. Kreis; Ivo van der Voort; Maximilian Gebhard; Jost Langhorst; Petra Lynen Jansen; Oliver Schwandner; Martin Storr; Pia van Leeuwen; Viola Andresen; Jan C. Preiß; Peter Layer; H. Allescher; T. Andus; S. C. Bischoff; S. Buderus; M. Claßen; U. Ehlert; S. Elsenbruch; M. Engel; A. Enninger; W. Fischbach; M. Freitag; T. Frieling; A. Gillessen; M. Goebel-Stengel; J. Gschossmann; F. Gundling; S. Haag; W. Häuser; U. Helwig; S. Hollerbach; G. Holtmann; M. Karaus; M. Katschinski; H. Krammer; W. Kruis; R. Kuhlbusch-Zicklam; P. Lynen Jansen; A. Madisch; H. Matthes; S. Miehlke; H. Mönnikes; S. Müller-Lissner; B. Niesler; C. Pehl; D. Pohl; C. Posovszky; M. Raithel; G. Röhrig-Herzog; R. Schäfert; M. Schemann; A. Schmidt-Choudhury; S. Schmiedel; A. Schweinlin; J. Schwille-Kiuntke; A. Stengel; J. Tesarz; W. Voderholzer; G. von Boyen; J. von Schönfeld; in Zusammenarbeit mit:; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM); Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI); Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV); Deutsche Gesellschaft für Ernährungsmedizin (DGEM); Deutsche Gesellschaft für Geriatrie (DGG); Deutsche Gesellschaft für Innere Medizin (DGIM); Deutsche Gesellschaft für Naturheilkunde (DGNHK); Deutsche Gesellschaft für Pathologie und Bundesverband deutscher Pathologen e. V. (DGP/BDP); Deutsche Gesellschaft für Psychosomatische Medizin und Ärztliche Psychotherapie (DGPM); Deutsche Gesellschaft für Verhaltensmedizin und Verhaltensmodifikation (DGVM); Deutsche Schmerzgesellschaft e. V., Deutsches Kollegium für Psychosomatische Medizin (DKPM); Deutsche Gesellschaft für Tropenmedizin und Internationale Gesundheit (DTG); Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE); Deutsche Gesellschaft für Kinder- und Jugendmedizin (DGKJ); Swiss Society of Neurogastroenterology and Motility (SwissNGM); Informationsforum für Patient:innen mit Magen-Darm-Erkrankungen (MAGDA)

doi:10.1055/a-1646-1279

Zeitschrift für Gastroenterologie, Table of Contents

Z Gastroenterol 2022; 60(02): 192-218
DOI: 10.1055/a-1646-1279

Leitlinie

Update S3-Leitlinie Intestinale Motilitätsstörungen: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)

Juni 2021 – AWMF-Registriernummer: 021-018

Jutta Keller

¹Medizinische Klinik, Israelitisches Krankenhaus in Hamburg, Hamburg, Deutschland

,

Thilo Wedel

²Institut für Anatomie, Christian-Albrechts-Universität Kiel, Kiel, Deutschland

,

Holger Seidl

³Klinik für Gastroenterologie, Hepatologie und Gastroenterologische Onkologie, Isarklinikum München, München, Deutschland

,

Martin E. Kreis

⁴Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Charité, Campus Benjamin Franklin, Berlin, Deutschland

,

Ivo van der Voort

⁵Klinik für Innere Medizin – Gastroenterologie und Diabetologie, Jüdisches Krankenhaus Berlin, Deutschland

,

Maximilian Gebhard

⁶Gemeinschaftspraxis Pathologie, Hamburg, Deutschland

,

Jost Langhorst

⁷Klinik für Integrative Medizin und Naturheilkunde, Klinikum Bamberg, Bamberg, Deutschland

,

Petra Lynen Jansen

⁸Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten, Berlin, Deutschland

,

Oliver Schwandner

⁹Abteilung für Proktologie, Krankenhaus Barmherzige Brüder, Regensburg

,

Martin Storr

¹⁰Zentrum für Endoskopie, Gesundheitszentrum Starnberger See, Starnberg

,

Pia van Leeuwen

⁸Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten, Berlin, Deutschland

,

Viola Andresen

¹Medizinische Klinik, Israelitisches Krankenhaus in Hamburg, Hamburg, Deutschland

,

Jan C. Preiß

¹¹Klinik für Innere Medizin – Gastroenterologie, Diabetologie und Hepatologie, Klinikum Neukölln, Berlin

,

Peter Layer

¹Medizinische Klinik, Israelitisches Krankenhaus in Hamburg, Hamburg, Deutschland

,

H. Allescher

,

T. Andus

,

S. C. Bischoff

,

S. Buderus

,

M. Claßen

,

U. Ehlert

,

S. Elsenbruch

,

M. Engel

,

A. Enninger

,

W. Fischbach

,

M. Freitag

,

T. Frieling

,

A. Gillessen

,

M. Goebel-Stengel

,

J. Gschossmann

,

F. Gundling

,

S. Haag

,

W. Häuser

,

U. Helwig

,

S. Hollerbach

,

G. Holtmann

,

M. Karaus

,

M. Katschinski

,

H. Krammer

,

W. Kruis

,

R. Kuhlbusch-Zicklam

,

P. Lynen Jansen

,

A. Madisch

,

H. Matthes

,

S. Miehlke

,

H. Mönnikes

,

S. Müller-Lissner

,

B. Niesler

,

C. Pehl

,

D. Pohl

,

C. Posovszky

,

M. Raithel

,

G. Röhrig-Herzog

,

R. Schäfert

,

M. Schemann

,

A. Schmidt-Choudhury

,

S. Schmiedel

,

A. Schweinlin

,

J. Schwille-Kiuntke

,

A. Stengel

,

J. Tesarz

,

W. Voderholzer

,

G. von Boyen

,

J. von Schönfeld

,

in Zusammenarbeit mit:, Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM), Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI), Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV), Deutsche Gesellschaft für Ernährungsmedizin (DGEM), Deutsche Gesellschaft für Geriatrie (DGG), Deutsche Gesellschaft für Innere Medizin (DGIM), Deutsche Gesellschaft für Naturheilkunde (DGNHK), Deutsche Gesellschaft für Pathologie und Bundesverband deutscher Pathologen e. V. (DGP/BDP), Deutsche Gesellschaft für Psychosomatische Medizin und Ärztliche Psychotherapie (DGPM), Deutsche Gesellschaft für Verhaltensmedizin und Verhaltensmodifikation (DGVM), Deutsche Schmerzgesellschaft e. V., Deutsches Kollegium für Psychosomatische Medizin (DKPM), Deutsche Gesellschaft für Tropenmedizin und Internationale Gesundheit (DTG), Gesellschaft für Pädiatrische Gastroenterologie und Ernährung (GPGE), Deutsche Gesellschaft für Kinder- und Jugendmedizin (DGKJ), Swiss Society of Neurogastroenterology and Motility (SwissNGM), Informationsforum für Patient:innen mit Magen-Darm-Erkrankungen (MAGDA) › Author Affiliations

Abstract

Schlüsselwörter

Reizdarm - Intestinale Motilität - Obstipation - Diarrhoe

Full Text

References

Literatur
1 Bundesärztekammer (BÄK) KBK, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Neuropathie bei Diabetes im Erwachsenenalter – Langfassung. 2011 http://www.diabetes.versorgungsleitlinien.de
2 Layer P, Andresen V, Pehl C. et al. S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM). Z Gastroenterol 2011; 49: 237-293
3 Phillips BDM, Ball C, Sackett D. et al. Oxford Centre for Evidence-based Medicine – Levels of Evidence CEBM. 2009 2009.
4 Connor FL, Di Lorenzo C. Chronic intestinal pseudo-obstruction: assessment and management. Gastroenterology 2006; 130: S29-S36
5 Stanghellini V, Cogliandro RF, de Giorgio R. et al. Chronic intestinal pseudo-obstruction: manifestations, natural history and management. Neurogastroenterol Motil 2007; 19: 440-452
6 Seidl H, Pehl C, Schepp W. et al. [Chronic intestinal pseudo-obstruction – review and update 2008]. Z Gastroenterol 2008; 46: 704-711
7 Kessmann J. Hirschsprungʼs disease: diagnosis and management. Am Fam Physician 2006; 74: 1319-1322
8 Knowles CH, Lindberg G, Panza E. et al. New perspectives in the diagnosis and management of enteric neuropathies. Nat Rev Gastroenterol Hepatol 2013; 10: 206-218
9 Goldstein AM, Thapar N, Karunaratne TB. et al. Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment. Dev Biol 2016; 417: 217-228
10 Furness JB. The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol 2012; 9: 286-294
11 Knowles CH, De Giorgio R, Kapur RP. et al. The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group. Gut 2010; 59: 882-887
12 Boeckxstaens G, Camilleri M, Sifrim D. et al. Fundamentals of Neurogastroenterology: Physiology/Motility – Sensation. Gastroenterology 2016; 150: 1292-1304
13 Vanner S, Greenwood-Van Meerveld B, Mawe G. et al. Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology 2016; 150: 1280-1291
14 De Giorgio R, Camilleri M. Human enteric neuropathies: morphology and molecular pathology. Neurogastroenterol Motil 2004; 16: 515-531
15 Di Lorenzo C. Pseudo-obstruction: current approaches. Gastroenterology 1999; 116: 980-987
16 De Giorgio R, Guerrini S, Barbara G. et al. New insights into human enteric neuropathies. Neurogastroenterol Motil 2004; 16 (Suppl. 01) 143-147
17 Brosens E, Burns AJ, Brooks AS. et al. Genetics of enteric neuropathies. Dev Biol 2016; 417: 198-208
18 Panza E, Knowles CH, Graziano C. et al. Genetics of human enteric neuropathies. Prog Neurobiol 2012; 96: 176-189
19 De Giorgio R, Guerrini S, Barbara G. et al. Inflammatory neuropathies of the enteric nervous system. Gastroenterology 2004; 126: 1872-1883
20 Smith VV, Gregson N, Foggensteiner L. et al. Acquired intestinal aganglionosis and circulating autoantibodies without neoplasia or other neural involvement. Gastroenterology 1997; 112: 1366-1371
21 Di Nardo G, Blandizzi C, Volta U. et al. Review article: molecular, pathological and therapeutic features of human enteric neuropathies. Aliment Pharmacol Ther 2008; 28: 25-42
22 Knowles CH, De Giorgio R, Kapur RP. et al. Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol 2009; 118: 271-301
23 Koh S, Bradley RF, French SW. et al. Congenital visceral myopathy with a predominantly hypertrophic pattern treated by multivisceral transplantation. Hum Pathol 2008; 39: 970-974
24 Dewit S, de Hertogh G, Geboes K. et al. Chronic intestinal pseudo-obstruction caused by an intestinal inflammatory myopathy: case report and review of the literature. Neurogastroenterol Motil 2008; 20: 343-348
25 Finsterer J. Overview on visceral manifestations of mitochondrial disorders. Neth J Med 2006; 64: 61-71
26 Bassotti G, Villanacci V, Fisogni S. et al. Enteric glial cells and their role in gastrointestinal motor abnormalities: introducing the neuro-gliopathies. World J Gastroenterol 2007; 13: 4035-4041
27 Grubisic V, Verkhratsky A, Zorec R. et al. Enteric glia regulate gut motility in health and disease. Brain Res Bull 2018; 136: 109-117
28 Sharkey KA. Emerging roles for enteric glia in gastrointestinal disorders. J Clin Invest 2015; 125: 918-925
29 Bassotti G, Villanacci V, Maurer CA. et al. The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation. Gut 2006; 55: 41-46
30 Bassotti G, Villanacci V, Cathomas G. et al. Enteric neuropathology of the terminal ileum in patients with intractable slow-transit constipation. Hum Pathol 2006; 37: 1252-1258
31 Bassotti G, Villanacci V, Nascimbeni R. et al. Colonic neuropathological aspects in patients with intractable constipation due to obstructed defecation. Mod Pathol 2007; 20: 367-374
32 Dinning PG, Bampton PA, Andre J. et al. Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation. Gastroenterology 2004; 127: 49-56
33 Iantorno G, Bassotti G, Kogan Z. et al. The enteric nervous system in chagasic and idiopathic megacolon. Am J Surg Pathol 2007; 31: 460-468
34 Sanders KM, Ward SM, Koh SD. Interstitial cells: regulators of smooth muscle function. Physiol Rev 2014; 94: 859-907
35 Sanders KM, Kito Y, Hwang SJ. et al. Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells. Physiology (Bethesda) 2016; 31: 316-326
36 Sarna SK. Are interstitial cells of Cajal plurifunction cells in the gut?. Am J Physiol Gastrointest Liver Physiol 2008; 294: G372-G390
37 Yanagida H, Yanase H, Sanders KM. et al. Intestinal surgical resection disrupts electrical rhythmicity, neural responses, and interstitial cell networks. Gastroenterology 2004; 127: 1748-1759
38 De Giorgio R, Sarnelli G, Corinaldesi R. et al. Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction. Gut 2004; 53: 1549-1552
39 Iida H, Ohkubo H, Inamori M. et al. Epidemiology and clinical experience of chronic intestinal pseudo-obstruction in Japan: a nationwide epidemiologic survey. J Epidemiol 2013; 23: 288-294
40 Smout AJ. Recent developments in gastrointestinal motility. Scand J Gastroenterol Suppl 2006: 25–31
41 Lindberg G, Tornblom H, Iwarzon M. et al. Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility. Gut 2009; 58: 1084-1090
42 Malagelada C, Karunaratne TB, Accarino A. et al. Comparison between small bowel manometric patterns and full-thickness biopsy histopathology in severe intestinal dysmotility. Neurogastroenterol Motil 2018; 30
43 Stanghellini V, Cogliandro RF, De Giorgio R. et al. Natural history of chronic idiopathic intestinal pseudo-obstruction in adults: a single center study. Clin Gastroenterol Hepatol 2005; 3: 449-458
44 Wells CI, OʼGrady G, Bissett IP. Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. World J Gastroenterol 2017; 23: 5634-5644
45 Ross SW, Oommen B, Wormer BA. et al. Acute Colonic Pseudo-obstruction: Defining the Epidemiology, Treatment, and Adverse Outcomes of Ogilvieʼs Syndrome. Am Surg 2016; 82: 102-111
46 Bernardi MP, Warrier S, Lynch AC. et al. Acute and chronic pseudo-obstruction: a current update. ANZ J Surg 2015; 85: 709-714
47 Saunders MD. Acute colonic pseudo-obstruction. Best Pract Res Clin Gastroenterol 2007; 21: 671-687
48 Vanek VW, Al-Salti M. Acute pseudo-obstruction of the colon (Ogilvie’s syndrome). An analysis of 400 cases. Dis Colon Rectum 1986; 29: 203-210
49 Gladman MA, Knowles CH. Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel. Colorectal Dis 2008; 10: 531-538 ; discussion 538–540
50 Bharucha AE. Constipation. Best Pract Res Clin Gastroenterol 2007; 21: 709-731
51 Martucciello G. Hirschsprungʼs disease, one of the most difficult diagnoses in pediatric surgery: a review of the problems from clinical practice to the bench. Eur J Pediatr Surg 2008; 18: 140-149
52 Heanue TA, Pachnis V. Enteric nervous system development and Hirschsprung’s disease: advances in genetic and stem cell studies. Nat Rev Neurosci 2007; 8: 466-479
53 Henderson D, Zimmer J, Nakamura H. et al. Hirschsprungʼs disease in twins: a systematic review and meta-analysis. Pediatr Surg Int 2017; 33: 855-859
54 Andresen VEP, Frieling T, Herold A. et al. S2k-Leitlinie Chronische Obstipation: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) und der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) AWMF-Registriernummer: 021/019. Z Gastroenterol 2013; 51: 21
55 Rao SS, Rattanakovit K, Patcharatrakul T. Diagnosis and management of chronic constipation in adults. Nat Rev Gastroenterol Hepatol 2016; 13: 295-305
56 Camilleri M, Ford AC, Mawe GM. et al. Chronic constipation. Nat Rev Dis Primers 2017; 3: 17095
57 Ouyang A, Locke 3^rd GR. Overview of neurogastroenterology-gastrointestinal motility and functional GI disorders: classification, prevalence, and epidemiology. Gastroenterol Clin North Am 2007; 36: 485-498, vii
58 Longstreth GF, Thompson WG, Chey WD. et al. Functional bowel disorders. Gastroenterology 2006; 130: 1480-1491
59 Wong SW, Lubowski DZ. Slow-transit constipation: evaluation and treatment. ANZ J Surg 2007; 77: 320-328
60 Knowles CH, Farrugia G. Gastrointestinal neuromuscular pathology in chronic constipation. Best Pract Res Clin Gastroenterol 2011; 25: 43-57
61 Bassotti G, Villanacci V. Slow transit constipation: a functional disorder becomes an enteric neuropathy. World J Gastroenterol 2006; 12: 4609-4613
62 Rao SS. Constipation: evaluation and treatment of colonic and anorectal motility disorders. Gastroenterol Clin North Am 2007; 36: 687-711, x
63 Bassotti G, Stanghellini V, Chiarioni G. et al. Upper gastrointestinal motor activity in patients with slow-transit constipation. Further evidence for an enteric neuropathy. Dig Dis Sci 1996; 41: 1999-2005
64 Seidl H, Gundling F, Pehl C. et al. Small bowel motility in functional chronic constipation. Neurogastroenterol Motil 2009; 21: 1278-e122
65 Glia A, Akerlund JE, Lindberg G. Outcome of colectomy for slow-transit constipation in relation to presence of small-bowel dysmotility. Dis Colon Rectum 2004; 47: 96-102
66 Andromanakos N, Skandalakis P, Troupis T. et al. Constipation of anorectal outlet obstruction: pathophysiology, evaluation and management. J Gastroenterol Hepatol 2006; 21: 638-646
67 Spiller R. Role of motility in chronic diarrhoea. Neurogastroenterol Motil 2006; 18: 1045-1055
68 Perez de Arce E, Landskron G, Hirsch S. et al. Chronic Intestinal Pseudo-obstruction: Clinical and Manometric Characteristics in the Chilean Population. J Neurogastroenterol Motil 2017; 23: 273-280
69 Camilleri M, Bharucha AE, di Lorenzo C. et al. American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil 2008; 20: 1269-1282
70 Keller J, Bassotti G, Clarke J. et al. Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders. Nat Rev Gastroenterol Hepatol 2018; 15: 291-308
71 Keller J, Franke A, Storr M. et al. Klinisch relevante Atemtests in der gastroenterologischen Diagnostik – Empfehlungen der Deutschen Gesellschaft fÅr Neurogastroenterologie und MotilitÑt sowie der Deutschen Gesellschaft fÅr Verdauungs- und Stoffwechselerkrankungen. Z Gastroenterol 2005; 43: 1071-1090
72 Amiot A, Joly F, Cazals-Hatem D. et al. Prognostic yield of esophageal manometry in chronic intestinal pseudo-obstruction: a retrospective cohort of 116 adult patients. Neurogastroenterol Motil 2012; 24: 1008-e542
73 Rao SS, Camilleri M, Hasler WL. et al. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil 2011; 23: 8-23
74 Bertram F, Andresen V, Layer P. et al. Simultaneous non-invasive measurement of liquid gastric emptying and small bowel transit by combined 13C-acetate and H2-lactulose breath test. J Breath Res 2014; 8: 046007
75 Antonucci A, Fronzoni L, Cogliandro L. et al. Chronic intestinal pseudo-obstruction. World J Gastroenterol 2008; 14: 2953-2961
76 Pehl C, Enck P, Franke A. et al. Empfehlungen zur anorektalen Manometrie im Erwachsenenalter. Z Gastroenterol 2007; 45: 397-417
77 De Giorgio R, Knowles CH. Acute colonic pseudo-obstruction. Br J Surg 2009; 96: 229-239
78 Eisen GM, Baron TH, Dominitz JA. et al. Acute colonic pseudo-obstruction. Gastrointest Endosc 2002; 56: 789-792
79 Saunders MD, Kimmey MB. Systematic review: acute colonic pseudo-obstruction. Aliment Pharmacol Ther 2005; 22: 917-925
80 OʼDwyer RH, Acosta A, Camilleri M. et al. Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults. Dig Dis Sci 2015; 60: 2398-2407
81 Camilleri M. New imaging in neurogastroenterology: an overview. Neurogastroenterol Motil 2006; 18: 805-812
82 Ohkubo H, Masaki T, Matsuhashi N. et al. Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. Neurogastroenterol Motil 2014; 26: 571-580
83 de Lorijn F, Kremer LC, Reitsma JB. et al. Diagnostic tests in Hirschsprung disease: a systematic review. J Pediatr Gastroenterol Nutr 2006; 42: 496-505
84 Friedmacher F, Puri P. Rectal suction biopsy for the diagnosis of Hirschsprungʼs disease: a systematic review of diagnostic accuracy and complications. Pediatr Surg Int 2015; 31: 821-830
85 Chen JZ, Jamieson DH, Skarsgard ED. Does pre-biopsy contrast enema delay the diagnosis of long segment Hirschsprung’s disease?. Eur J Pediatr Surg 2010; 20: 375-378
86 Frongia G, Gunther P, Schenk JP. et al. Contrast Enema for Hirschsprung Disease Investigation: Diagnostic Accuracy and Validity for Subsequent Diagnostic and Surgical Planning. Eur J Pediatr Surg 2016; 26: 207-214
87 Rao SS, Ozturk R, Laine L. Clinical utility of diagnostic tests for constipation in adults: a systematic review. Am J Gastroenterol 2005; 100: 1605-1615
88 An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol 2005; 100 (Suppl. 01) S1-S4
89 Keller J, Layer P. Intestinal and anorectal motility and functional disorders. Best Pract Res Clin Gastroenterol 2009; 23: 407-423
90 Mion F, Garros A, Brochard C. et al. 3D High-definition anorectal manometry: Values obtained in asymptomatic volunteers, fecal incontinence and chronic constipation. Results of a prospective multicenter study (NOMAD). Neurogastroenterol Motil 2017; 29
91 Grossi U, Carrington EV, Bharucha AE. et al. Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation. Gut 2016; 65: 447-455
92 Asrani VM, Yoon HD, Megill RD. et al. Interventions That Affect Gastrointestinal Motility in Hospitalized Adult Patients: A Systematic Review and Meta-Analysis of Double-Blind Placebo-Controlled Randomized Trials. Medicine (Baltimore) 2016; 95: e2463
93 Turgeon DK. Domperidone in chronic intestinal pseudoobstruction. Gastroenterology 1990; 99: 1194
94 Dalgic B, Sari S, Dogan I. et al. Chronic intestinal pseudoobstruction: report of four pediatric patients. Turk J Gastroenterol 2005; 16: 93-97
95 Emmanuel AV, Shand AG, Kamm MA. Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with a positive response. Aliment Pharmacol Ther 2004; 19: 687-694
96 Verne GN, Eaker EY, Hardy E. et al. Effect of octreotide and erythromycin on idiopathic and scleroderma-associated intestinal pseudoobstruction. Dig Dis Sci 1995; 40: 1892-901
97 Emmanuel AV, Kamm MA, Roy AJ. et al. Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study. Aliment Pharmacol Ther 2012; 35: 48-55
98 Manini ML, Camilleri M, Grothe R. et al. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs 2018; 20: 173-180
99 OʼDea CJ, Brookes JH, Wattchow DA. The efficacy of treatment of patients with severe constipation or recurrent pseudo-obstruction with pyridostigmine. Colorectal Dis 2010; 12: 540-548
100 Ambartsumyan L, Flores A, Nurko S. et al. Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. Paediatr Drugs 2016; 18: 387-392
101 Xu N, Zhao J, Liu J. et al. Clinical analysis of 61 systemic lupus erythematosus patients with intestinal pseudo-obstruction and/or ureterohydronephrosis: a retrospective observational study. Medicine (Baltimore) 2015; 94: e419
102 Raja J, Nihtyanova SI, Murray CD. et al. Sustained benefit from intravenous immunoglobulin therapy for gastrointestinal involvement in systemic sclerosis. Rheumatology (Oxford) 2016; 55: 115-119
103 Flanagan EP, Saito YA, Lennon VA. et al. Immunotherapy trial as diagnostic test in evaluating patients with presumed autoimmune gastrointestinal dysmotility. Neurogastroenterol Motil 2014; 26: 1285-1297
104 Nee J, Zakari M, Sugarman MA. et al. Efficacy of Treatments for Opioid-Induced Constipation: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018; 16: 1569-1584.e2
105 Kaufman PN, Krevsky B, Malmud LS. et al. Role of opiate receptors in the regulation of colonic transit. Gastroenterology 1988; 94: 1351-1356
106 Di Stefano M, Malservisi S, Veneto G. et al. Rifaximin versus chlortetracycline in the short-term treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther JID – 8707234 2000; 14: 551-556
107 Lauritano EC, Gabrielli M, Scarpellini E. et al. Antibiotic therapy in small intestinal bacterial overgrowth: rifaximin versus metronidazole. Eur Rev Med Pharmacol Sci 2009; 13: 111-116
108 Pironi L, Arends J, Bozzetti F. et al. ESPEN guidelines on chronic intestinal failure in adults. Clin Nutr 2016; 35: 247-307
109 Olausson EA, Storsrud S, Grundin H. et al. A small particle size diet reduces upper gastrointestinal symptoms in patients with diabetic gastroparesis: a randomized controlled trial. Am J Gastroenterol 2014; 109: 375-385
110 Camilleri M, Kerstens R, Rykx A. et al. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 2008; 358: 2344-2354
111 Tack J, van Outryve M, Beyens G. et al. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut 2009; 58: 357-365
112 Yiannakou Y, Bouchoucha M, Schiefke I. et al. Efficacy and safety of prucalopride in men with chronic constipation: a phase 3, randomized, double-blind, placebo-controlled trial. Gastroenterology 2014; 146: 1
113 Ponec RJ, Saunders MD, Kimmey MB. Neostigmine for the treatment of acute colonic pseudo-obstruction. N Engl J Med 1999; 341: 137-141
114 Schang JC, Devroede G. Beneficial effects of naloxone in a patient with intestinal pseudoobstruction. Am J Gastroenterol 1985; 80: 407-411
115 Wang JL, Liu G, Liu T. et al. Intestinal pseudo-obstruction in systemic lupus erythematosus: a case report and review of the literature. Medicine (Baltimore) 2014; 93: e248
116 Husebye E. The pathogenesis of gastrointestinal bacterial overgrowth. Chemotherapy 2005; 51 (Suppl. 01) 1-22
117 Lloyd DA, Gabe SM. Managing liver dysfunction in parenteral nutrition. Proc Nutr Soc 2007; 66: 530-538
118 Sabate JM, Jouet P, Harnois F. et al. High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis. Obes Surg 2008; 18: 371-377
119 Grunkemeier DM, Cassara JE, Dalton CB. et al The narcotic bowel syndrome: clinical features, pathophysiology, and management. Clin Gastroenterol Hepatol 2007; 5: 1126-1139 ; quiz 1121–1122
120 Tuteja AK, Biskupiak J, Stoddard GJ. et al. Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain. Neurogastroenterol Motil 2010; 22: 424-430, e96
121 Jeong ID, Camilleri M, Shin A. et al. A randomised, placebo-controlled trial comparing the effects of tapentadol and oxycodone on gastrointestinal and colonic transit in healthy humans. Aliment Pharmacol Ther 2012; 35: 1088-1096
122 Gaskell H, Derry S, Stannard C. et al. Oxycodone for neuropathic pain in adults. Cochrane Database Syst Rev 2016; 7: Cd010692
123 Szigethy E, Knisely M, Drossman D. Opioid misuse in gastroenterology and non-opioid management of abdominal pain. Nat Rev Gastroenterol Hepatol 2018; 15: 168-180
124 Ohkubo H, Fuyuki A, Arimoto J. et al. Efficacy of percutaneous endoscopic gastro-jejunostomy (PEG-J) decompression therapy for patients with chronic intestinal pseudo-obstruction (CIPO). Neurogastroenterol Motil 2017; 29
125 Tun G, Bullas D, Bannaga A. et al. Percutaneous endoscopic colostomy: a useful technique when surgery is not an option. Ann Gastroenterol 2016; 29: 477-480
126 Sabbagh C, Amiot A, Maggiori L. et al. Non-transplantation surgical approach for chronic intestinal pseudo-obstruction: analysis of 63 adult consecutive cases. Neurogastroenterol Motil 2013; 25: e680-e686
127 Mehendale SR, Yuan CS. Opioid-induced gastrointestinal dysfunction. Dig Dis 2006; 24: 105-112
128 Panchal SJ, Muller-Schwefe P, Wurzelmann JI. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden. Int J Clin Pract 2007; 61: 1181-1187
129 Lauro A, Zanfi C, Pellegrini S. et al. Isolated intestinal transplant for chronic intestinal pseudo-obstruction in adults: long-term outcome. Transplant Proc 2013; 45: 3351-3355
130 Gu L, Ding C, Tian H. et al. Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study. J Neurogastroenterol Motil 2017; 23: 289-297
131 Hashizume N, Yagi M, Ushijima K. et al. Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction: Nationwide survey in Japan. Pediatr Int 2017; 59: 467-472
132 Loftus CG, Harewood GC, Baron TH. Assessment of predictors of response to neostigmine for acute colonic pseudo-obstruction. Am J Gastroenterol 2002; 97: 3118-3122
133 Zhao C, Xie T, Li J. et al. Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis. Gastroenterol Res Pract 2017; 2017: 9574592
134 van der Spoel JI, Oudemans-van Straaten HM, Stoutenbeek CP. et al. Neostigmine resolves critical illness-related colonic ileus in intensive care patients with multiple organ failure--a prospective, double-blind, placebo-controlled trial. Intensive Care Med 2001; 27: 822-827
135 Rao SS, Yu S, Fedewa A. Systematic review: dietary fibre and FODMAP-restricted diet in the management of constipation and irritable bowel syndrome. Aliment Pharmacol Ther 2015; 41: 1256-1270
136 Klauser AG, Beck A, Schindlbeck NE. et al. Low fluid intake lowers stool output in healthy male volunteers. Z Gastroenterol 1990; 28: 606-609
137 Chien LY, Liou YM, Chang P. Low defaecation frequency in Taiwanese adolescents: association with dietary intake, physical activity and sedentary behaviour. J Paediatr Child Health 2011; 47: 381-386
138 Anti M, Pignataro G, Armuzzi A. et al. Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepatogastroenterology 1998; 45: 727-732
139 Chung BD, Parekh U, Sellin JH. Effect of increased fluid intake on stool output in normal healthy volunteers. J Clin Gastroenterol 1999; 28: 29-32
140 Wood LN, Markowitz MA, Parameshwar PS. et al. Is it Safe to Reduce Water Intake in the Overactive Bladder Population? A Systematic Review. J Urol 2018; 200: 375-381
141 Yang J, Wang HP, Zhou L. et al. Effect of dietary fiber on constipation: a meta analysis. World J Gastroenterol 2012; 18: 7378-7383
142 Ford AC, Suares NC. Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis. Gut 2011; 60: 209-218
143 Dinning PG, Hunt L, Lubowski DZ. et al. The impact of laxative use upon symptoms in patients with proven slow transit constipation. BMC Gastroenterol 2011; 11: 121
144 Emmanuel A, Cools M, Vandeplassche L. et al. Prucalopride improves bowel function and colonic transit time in patients with chronic constipation: an integrated analysis. Am J Gastroenterol 2014; 109: 887-894
145 Shah ED, Kim HM, Schoenfeld P. Efficacy and Tolerability of Guanylate Cyclase-C Agonists for Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation: A Systematic Review and Meta-Analysis. Am J Gastroenterol 2018; 113: 329-338
146 Quartero AO, Meineche-Schmidt V, Muris J. et al Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome. Cochrane Database Syst Rev 2005: CD003460
147 Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005; 100: 936-971
148 Muller-Lissner SA, Kamm MA, Scarpignato C. et al. Myths and misconceptions about chronic constipation. Am J Gastroenterol 2005; 100: 232-242
149 Bharucha AE, Low P, Camilleri M. et al. A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipation. Gut 2013; 62: 708-715
150 Bassotti G, Chiarioni G, Vantini I. et al. Effect of different doses of erythromycin on colonic motility in patients with slow transit constipation. Z Gastroenterol 1998; 36: 209-213
151 Dranove J, Horn D, Reddy SN. et al. Effect of intravenous erythromycin on the colonic motility of children and young adults during colonic manometry. J Pediatr Surg 2010; 45: 777-783
152 Lacy BE, Schey R, Shiff SJ. et al. Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial. PLoS One 2015; 10: e0134349
153 Schoenfeld P, Lacy BE, Chey WD. et al. Low-Dose Linaclotide (72 mug) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial. Am J Gastroenterol 2018; 113: 105-114
154 Fukudo S, Miwa H, Nakajima A. et al. Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study. Neurogastroenterol Motil 2018; 30: e13442
155 Andresen V, Camilleri M, Busciglio IA. et al. Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology 2007; 133: 761-768
156 Fukudo S, Hongo M, Kaneko H. et al. Lubiprostone increases spontaneous bowel movement frequency and quality of life in patients with chronic idiopathic constipation. Clin Gastroenterol Hepatol 2015; 13: 294-301.e5
157 Mollenbrink M, Bruckschen E. [Treatment of chronic constipation with physiologic Escherichia coli bacteria. Results of a clinical study of the effectiveness and tolerance of microbiological therapy with the E. coli Nissle 1917 strain (Mutaflor)]. Med Klin (Munich) 1994; 89: 587-593
158 Voderholzer WA, Schatke W, Muhldorfer BE. et al. Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol 1997; 92: 95-98
159 Yi Z, Jie C, Wenyi Z. et al. Comparison of efficacies of vegetable oil based and polyethylene glycol based bisacodyl suppositories in treating patients with neurogenic bowel dysfunction after spinal cord injury: a meta-analysis. Turk J Gastroenterol 2014; 25: 488-492
160 Ruidisch MHH, H.J.; König, E. Laxanzien-Langzeittherapie mit Bisacodyl. Wirksamkeit und Verträglichkeit bei Patienten mit Rückenmarkverletzungen. Ärztliche Forschung 1994; 41: 3-8
161 Lazzaroni M, Casini V, Bianchi Porro G. Role or carbon dioxide-releasing suppositories in the treatment of chronic functional constipation: a double-blind, randomised, placebo-controlled trial. Clin Drug Investig 2005; 25: 499-505
162 Chiarioni G, Heymen S, Whitehead WE. Biofeedback therapy for dyssynergic defecation. World J Gastroenterol 2006; 12: 7069-7074
163 Heymen S, Scarlett Y, Jones K. et al. Randomized, controlled trial shows biofeedback to be superior to alternative treatments for patients with pelvic floor dyssynergia-type constipation. Dis Colon Rectum 2007; 50: 428-441
164 Chiarioni G, Salandini L, Whitehead WE. Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation. Gastroenterology 2005; 129: 86-97
165 Koh CE, Young CJ, Young JM. et al. Systematic review of randomized controlled trials of the effectiveness of biofeedback for pelvic floor dysfunction. Br J Surg 2008; 95: 1079-1087
166 Enck P, Van der Voort IR, Klosterhalfen S. Biofeedback therapy in fecal incontinence and constipation. Neurogastroenterol Motil 2009; 21: 1133-1141
167 Woodward S, Norton C, Chiarelli P. Biofeedback for treatment of chronic idiopathic constipation in adults. Cochrane Database Syst Rev 2014: Cd008486
168 Rao SS, Benninga MA, Bharucha AE. et al. ANMS-ESNM position paper and consensus guidelines on biofeedback therapy for anorectal disorders. Neurogastroenterol Motil 2015; 27: 594-609
169 Lee HJ, Jung KW, Myung SJ. Technique of functional and motility test: how to perform biofeedback for constipation and fecal incontinence. J Neurogastroenterol Motil 2013; 19: 532-537
170 Emile SH, Elfeki HA, Elbanna HG. et al. Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review. World J Gastrointest Pharmacol Ther 2016; 7: 453-462
171 Han-Geurts IJ, Hendrix VC, de Blaauw I. et al. Outcome after anal intrasphincteric Botox injection in children with surgically treated Hirschsprung disease. J Pediatr Gastroenterol Nutr 2014; 59: 604-607
172 Dinning PG, Hunt L, Patton V. et al. Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study. Am J Gastroenterol 2015; 110: 733-740
173 Kamm MA, Dudding TC, Melenhorst J. et al. Sacral nerve stimulation for intractable constipation. Gut 2010; 59: 333-340
174 Carrington EV, Evers J, Grossi U. et al. A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil 2014; 26: 1222-1237
175 Neuvonen MI, Kyrklund K, Rintala RJ. et al. Bowel Function and Quality of Life After Transanal Endorectal Pull-through for Hirschsprung Disease: Controlled Outcomes up to Adulthood. Annals of surgery 2017; 265: 622-629
176 Coran AG, Teitelbaum DH. Recent advances in the management of Hirschsprungʼs disease. Am J Surg 2000; 180: 382-387
177 Weidner BC, Waldhausen JH. Swenson revisited: a one-stage, transanal pull-through procedure for Hirschsprungʼs disease. J Pediatr Surg 2003; 38: 1208-1211
178 Rintala RJ. Transanal coloanal pull-through with a short muscular cuff for classic Hirschsprung’s disease. Eur J Pediatr Surg 2003; 13: 181-186
179 Hadidi A. Transanal endorectal pull-through for Hirschsprungʼs disease: a comparison with the open technique. Eur J Pediatr Surg 2003; 13: 176-180
180 Langer JC, Durrant AC, de la Torre L. et al One-stage transanal Soave pullthrough for Hirschsprung disease: a multicenter experience with 141 children. Ann Surg 2003; 238: 569-583 ; discussion 583–585
181 Tomita R, Ikeda T, Fujisaki S. et al. Hirschsprungʼs disease and its allied disorders in adults' histological and clinical studies. Hepatogastroenterology 2003; 50: 1050-1053
182 Saleh W, Rasheed K, Mohaidly MA. et al. Management of Hirschsprungʼs disease: a comparison of Soaveʼs and Duhamelʼs pull-through methods. Pediatr Surg Int 2004; 20: 590-593
183 Chen Y, Nah SA, Laksmi NK. et al. Transanal endorectal pull-through versus transabdominal approach for Hirschsprung’s disease: a systematic review and meta-analysis. J Pediatr Surg 2013; 48: 642-651
184 Hyman PE. Adolescents and young adults with Hirschsprungʼs disease. Curr Gastroenterol Rep 2006; 8: 425-429
185 Miyamoto M, Egami K, Maeda S. et al. Hirschsprung’s disease in adults: report of a case and review of the literature. J Nippon Med Sch 2005; 72: 113-120
186 Nyam DC, Pemberton JH, Ilstrup DM. et al. Long-term results of surgery for chronic constipation. Dis Colon Rectum 1997; 40: 273-279
187 Kamm MA, Hawley PR, Lennard-Jones JE. Outcome of colectomy for severe idiopathic constipation. Gut 1988; 29: 969-973
188 Ripetti V, Caputo D, Greco S. et al. Is total colectomy the right choice in intractable slow-transit constipation?. Surgery 2006; 140: 435-440