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DOI: 10.1055/a-1647-7202
Stereoselective Synthesis of the C19–C39 Fragment of Bastimolide A
N.S.K. thanks the University Grants Commission (UGC) New Delhi for a fellowship, and B.J.R. thanks the Science and Engineering Research Board (SERB) for a National Post Doctoral Fellowship (N-PDF).
Abstract
This paper describes the synthesis of the C19–C39 fragment of the antimalarial natural product bastimolide A via addition of a functionalized C19–C26 alkyne fragment to a C27–C39 aldehyde fragment. Opening of a terminal epoxide and Noyori asymmetric reduction were used as key steps in the synthesis.
Key words
bastimolide A - antimalarial activity - stereoselective synthesis - epoxide opening - Noyori asymmetric reductionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1647-7202.
- Supporting Information
Publication History
Received: 30 August 2021
Accepted after revision: 16 September 2021
Accepted Manuscript online:
17 September 2021
Article published online:
06 October 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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