This manuscript is dedicated to Prof. (em). Richard R. Schmidt for his notable contribution on imidate chemistry
Abstract
A facile route for the synthesis of a diverse range of N-acylbenzotriazole derivatives from the corresponding carboxylic acids has been established through a carbonyl activation pathway. In this method, trichloroacetonitrile is performed as an effective reagent for an easy access of N-acylbenzotriazoles which was simply proceeded through the activation of carboxylic acids via in situ imidate formation in anhydrous 1,2-dichloroethane followed by addition of 1H-benzotriazole at 80 °C for 3–4 h. Easy handling, one-pot, and metal-free conditions demonstrate the notable merits of the devised protocol.
Keywords
N-acylbenzotriazole - benzotriazole - coupling reaction - imidate - trichloroacetonitrile
