PDF herunterladen
Zeitschrift für Phytotherapie 2022; 43(02): 67-72
DOI: 10.1055/a-1664-6596
Forschung

Das therapeutische Potenzial von Picrorhiza kurroa bei der Behandlung von Lebererkrankungen

Überblick über den aktuellen WissensstandThe Therapeutic Potential of Picrorhiza kurroa in the Treatment of Liver Disease: Overview of the Current State of Knowledge
Anna Magiera 
1   Abteilung für Pharmakognosie, Medizinische Universität Łódź, Polen
› Institutsangaben
› Weitere Informationen
    Lizenzen und Reprints

Zusammenfassung

Die Wirksamkeit von Naturstoffen hinsichtlich einer leberschützenden Aktivität wurde in der Wissenschaftsliteratur bereits häufig beschrieben. In letzter Zeit wächst in Europa das Interesse an pflanzlichen Stoffen, deren therapeutische Wirksamkeit durch die östliche Medizin (u. a. der ayurvedischen Medizin) bestätigt wird. Ein Beispiel für eine aus der ayurvedischen Medizin stammende Droge mit Heilpotenzial bei Lebererkrankungen ist die Wurzel und das Rhizom von Picrorhiza kurroa (zur Familie der Scrophulariaceae gehörend). Das Ziel dieser Übersichtsarbeit ist, den aktuellen Wissensstand über diesen natürlichen Rohstoff, seine chemische Zusammensetzung, das therapeutische Potenzial bei der Behandlung von Leberbeschwerden, die Toxizität und die Anwendungssicherheit zusammenzufassen.

Abstract

The effectiveness of natural products in the context of hepatoprotective activity has been widely described in the scientific literature. Recently, Asian herbal drugs have become more and more popular in Europe if their therapeutic effectiveness is confirmed by Eastern medicine, e. g., Ayurveda. An example of a plant material derived from Ayurvedic medicine with healing potential in liver diseases is the root and rhizome of Picrorhiza kurroa, which belongs to the Scrophulariaceae family. This review summarizes the current state of knowledge about this herbal drug, its chemical composition, therapeutic potential in the treatment of liver ailments, toxicity and safety of use.

Schlüsselwörter

Picrorhiza kurroa - Lebererkrankungen - ayurvedische Medizin

Key words

Picrorhiza kurroa - liver disease - Ayurvedic medicine


Publikationsverlauf

Artikel online veröffentlicht:
09. März 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Banerjee D, Maity B, Nag SK. et al. Healing potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration. BMC Complement Altern Med 2008; 8: 3
    CrossrefPubMedSuche in Google Scholar
  • 2 Bhardwaj A, Sharma A, Cooper R. A comprehensive phytochemical, ethnomedicinal, pharmacological ecology and conservation status of Picrorhiza kurroa Royle ex Benth. An endangered Himalayan medicinal plant. Process Biochem 2021; 109: 72-86
    CrossrefPubMedSuche in Google Scholar
  • 3 Bigoniya P, Shukla A, Singh CS. Evaluation of hepatic microsomal enzyme functional integrity on Picroliv pretreatment against CCl4 induced hepatotoxicity. Int J Pharm 2010; 6: 200-207
    CrossrefPubMedSuche in Google Scholar
  • 4 Bohraa N, Prasad P, Tewari G, Tewaria LM. Variation in picrotin and picrotoxin content of Picrorhiza kurroa Royle ex Benth rhizomes from Garhwal Himalaya. J Indian Chem Soc 2015; 92: 375-378
    CrossrefPubMedSuche in Google Scholar
  • 5 Girish C, Koner BC, Jayanthi S. et al. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol 2009; 23: 735-745
    CrossrefPubMedSuche in Google Scholar
  • 6 Girish C, Pradhan SC. Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice. J Pharmacol Pharmacother 2012; 3: 149-155
    CrossrefPubMedSuche in Google Scholar
  • 7 Husain GM, Singh PN, Kumar V. Antidiabetic activity of standardized extract of Picrorhiza kurroa in rat model of NIDDM. Drug Discov Ther 2009; 3: 88-92
    PubMedSuche in Google Scholar
  • 8 Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett 1999; 136: 11-16
    CrossrefPubMedSuche in Google Scholar
  • 9 Jeyakumar R, Rajesh R, Rajaprabhu D. et al. Hepatoprotective effect of Picrorrhiza kurroa on antioxidant defense system in antitubercular drugs induced hepatotoxicity in rats. Afr J Biotechnol 2009; 8: 1314-1315
    PubMedSuche in Google Scholar
  • 10 Krupashree K, Hemanth Kumar K, Rachitha P. et al. Chemical composition, antioxidant and macromolecule damage protective effects of Picrorhiza kurroa Royle ex Benth. S Afr J Bot 2014; 94: 249-254
    CrossrefPubMedSuche in Google Scholar
  • 11 Kumar S, Patial V, Soni S. et al. Picrorhiza kurroa enhances β-Cell mass proliferation and insulin secretion in streptozotocin evoked β-Cell damage in rats. Front Pharmacol 2017; 8: 537
    CrossrefPubMedSuche in Google Scholar
  • 12 Kumar V, Mehrotra N, Lal J, Gupta RC. Pattern profiling of the herbal preparation picroliv using liquid chromatography-tandem mass spectrometry. J Chromatogr A 2004; 1045: 145-152
    CrossrefPubMedSuche in Google Scholar
  • 13 Mallick MN, Singh M, Parveen R. et al. HPTLC analysis of bioactivity guided anticancer enriched fraction of hydroalcoholic extract of Picrorhiza kurroa . Biomed Res Int 2015; 2015: 513875
    CrossrefPubMedSuche in Google Scholar
  • 14 Morikawa T, Nakanishi Y, Inoue N. et al. Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth. Phytochemistry 2020; 169: 112185
    CrossrefPubMedSuche in Google Scholar
  • 15 Rastogi R, Srivastava AK, Rastogi AK. Long term effect of aflatoxin B(1) on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytother Res 2001; 15: 307-310
    CrossrefPubMedSuche in Google Scholar
  • 16 Ray A, Chaudhuri SR, Majumdar B, Bandyopadhyay SK. Antioxidant activity of ethanol extract of rhizome of Picrorhiza kurroa on indomethacin induced gastric ulcer during healing. Indian J Clin Biochem 2002; 17: 44-51
    CrossrefPubMedSuche in Google Scholar
  • 17 Saraswat B, Visen PK, Patnaik GK, Dhawan BN. Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats. J Ethnopharmacol 1999; 66: 263-269
    CrossrefPubMedSuche in Google Scholar
  • 18 Shetty SN, Mengi S, Vaidya R, Vaidya AD. A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease. J Ayurveda Integr Med 2010; 1: 203-210
    CrossrefPubMedSuche in Google Scholar
  • 19 Singh M, Tiwari V, Jain A, Ghoshal S. Protective activity of picroliv on hepatic amoebiasis associated with carbon tetrachloride toxicity. Indian J Med Res 2005; 121: 676-682
    PubMedSuche in Google Scholar
  • 20 Sinha S, Bhat J, Joshi M. et al. Hepatoprotective activity of Picrorhiza kurroa Royle Ex. Benth extract against alcohol cytotoxicity in mouse liver slice culture. Int J Green Pharmacy 2011; 5: 244-253
    CrossrefPubMedSuche in Google Scholar
  • 21 Stuppner H, Wagner H. New cucurbitacin glycosides from Picrorhiza kurrooa . Planta Med 1989; 55: 559-563
    Thieme ConnectPubMedSuche in Google Scholar
  • 22 Stuppner H, Müller EP, Wagner H. Cucurbitacins from Picrorhiza kurrooa . Phytochemistry 1991; 30: 305-310
    CrossrefPubMedSuche in Google Scholar
  • 23 Stuppner H, Moller EP. Cucurbitacins with unusual side chains from Picrorhiza kurroa . Phytochemistry 1993; 33: 1139-1145
    CrossrefPubMedSuche in Google Scholar
  • 24 Tabassam Q, Mehmood T, Ahmed S. et al. GC-MS metabolomics profiling and HR-APCI-MS characterization of potential anticancer compounds and antimicrobial activities of extracts from Picrorhiza kurroa roots. J Appl Biomed 2021; 19: 26-39
    CrossrefPubMedSuche in Google Scholar
  • 25 Vivekanandan P, Gobianand K, Priya S. et al. Protective effect of picroliv against hydrazine-induced hyperlipidemia and hepatic steatosis in rats. Drug Chem Toxicol 2007; 30: 241-252
    CrossrefPubMedSuche in Google Scholar