Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000031.xml
Klin Monbl Augenheilkd 2022; 239(02): 158-164
DOI: 10.1055/a-1667-6648
DOI: 10.1055/a-1667-6648
Übersicht
Corneal Biomechanics in Glaucoma
Article in several languages: deutsch | English
Abstract
Now that is possible to measure the biomechanical parameters of the cornea in vivo, scientific and clinical interest has increased in changes in these parameters in glaucoma. These parameters may act as biomarkers for early diagnosis, but also serve to emphasize the increased vulnerability to intraocular pressure, reduced blood flow or changing ocular perfusion pressure. Measuring and interpreting these parameters may help in achieving better and individually tailored glaucoma management.
Key words
open-angle glaucoma - normal pressure glaucoma - corneal biomechanics - corneal hysteresis - biomechanical glaucoma factorPublication History
Received: 31 August 2021
Accepted: 29 October 2021
Article published online:
24 February 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur/References
- 1 Yang H, Reynaud J, Lockwood H. et al. The connective tissue phenotype of glaucomatous cupping in the monkey eye – clinical and research implications. Prog Retin Eye Res 2017; 59: 1-52
- 2 Spoerl E, Pillunat KR, Kuhlisch E. et al. Concept for analyzing biomechanical parameters in clinical studies. Cont Lens Anterior Eye 2015; 38: 389
- 3 Spörl E, Terai N, Haustein M. et al. [Biomechanical condition of the cornea as a new indicator for pathological and structural changes]. Ophthalmologe 2009; 106: 512-520
- 4 Vinciguerra R, Elsheikh A, Roberts CJ. et al. Influence of Pachymetry and Intraocular Pressure on Dynamic Corneal Response Parameters in Healthy Patients. J Refract Surg 2016; 32: 550-561
- 5 Congdon NG, Broman AT, Bandeen-Roche K. et al. Central corneal thickness and corneal hysteresis associated with glaucoma damage. Am J Ophthalmol 2006; 141: 868-875
- 6 De Moraes CV, Hill V, Tello C. et al. Lower corneal hysteresis is associated with more rapid glaucomatous visual field progression. J Glaucoma 2012; 21: 209-213
- 7 Park JH, Jun RM, Choi KR. Significance of corneal biomechanical properties in patients with progressive normal-tension glaucoma. Br J Ophthalmol 2015; 99: 746-751
- 8 Medeiros FA, Meira-Freitas D, Lisboa R. et al. Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study. Ophthalmology 2013; 120: 1533-1540
- 9 Pillunat KR, Hermann C, Spoerl E. et al. Analyzing biomechanical parameters of the cornea with glaucoma severity in open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 2016; 254: 1345-1351
- 10 Anand A, De Moraes CG, Teng CC. et al. Corneal hysteresis and visual field asymmetry in open angle glaucoma. Invest Ophthalmol Vis Sci 2010; 51: 6514-6518
- 11 Asefa NG, Neustaeter A, Jansonius NM. et al. Heritability of glaucoma and glaucoma-related endophenotypes: Systematic review and meta-analysis. Surv Ophthalmol 2019; 64: 835-851
- 12 Carbonaro F, Andrew T, Mackey DA. et al. The heritability of corneal hysteresis and ocular pulse amplitude: a twin study. Ophthalmology 2008; 115: 1545-1549
- 13 Freeman EE, Roy-Gagnon MH, Descovich D. et al. The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, and choroidal blood flow pulsatility. PLoS One 2013; 8: e55573
- 14 Ishii K, Saito K, Kameda T. et al. Elastic hysteresis in human eyes is an age-dependent value. Clin Exp Ophthalmol 2013; 41: 6-11
- 15 Kass MA, Heuer DK, Higginbotham EJ. et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 2002; 120: 701-713
- 16 Gordon MO, Beiser JA, Brandt JD. et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 2002; 120: 714-720
- 17 Vinciguerra R, Ambrosio jr. R, Elsheikh A. et al. Detection of Keratoconus With a New Biomechanical Index. J Refract Surg 2016; 32: 803-810
- 18 Chan TCY, Wang YM, Yu M. et al. Comparison of Corneal Tomography and a New Combined Tomographic Biomechanical Index in Subclinical Keratoconus. J Refract Surg 2018; 34: 616-621
- 19 Pillunat KR, Herber R, Spoerl E. et al. A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes. Acta Ophthalmol 2019; 97: E962-E967
- 20 Pillunat KR. Veränderung kornealer biomechanischer Parameter bei Glaukom und nach Glaukom-Chirurgie [research thesis]. Dresden, Germany: Medical Faculty Carl Gustav Carus, Techical University Dresden; 2019