Enantioselective Construction of Multi-Nitrogen-Containing Spirocycles: Asymmetric [3+2] Annulation of 4-Isothiocyanato­pyrazolones with Azodicarboxylates

Abstract

The 4-isothiocyanatopyrazolones were exploited as a class of efficient synthons for the construction of triazoline derivatives via asymmetric [3+2] annulation with azodicarboxylates, providing a wide range of structurally diverse multi-nitrogen-containing spirocycles in excellent yields (up to 97%) with excellent enantioselectivities (up to 97% ee).

Key words

asymmetric catalysis - isothiocyanatopyrazolones - triazolines - annulation - enantioselectivity

Publication History

Received: 11 August 2021

Accepted after revision: 19 October 2021

Accepted Manuscript online:
19 October 2021

Article published online:
29 November 2021

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