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Synthesis 2022; 54(05): 1388-1394
DOI: 10.1055/a-1679-7753
DOI: 10.1055/a-1679-7753
paper
The Preparation and Application of Diaryliodonium Salts Derived from Gemfibrozil and Gemfibrozil Methyl Ester
This work was supported by the National Key Research and Development Program of China (2016YFB0401400), the National Natural Science Foundation of China (22071129, 21871158), the Department of Education of Guangdong Province (No. 2016KCXTD005), and the Youth Foundation of Wuyi University (No. 2017td01).
Abstract
The diaryliodonium salts derived from gemfibrozil and gemfibrozil methyl ester were synthesized from ArI(OH)OTs or bis(4-methoxyphenyl)iodonium diacetate with good regioselectivity. These iodonium salts were successfully used in the derivatization of gemfibrozil or gemfibrozil methyl ester, including fluorination, alkynylation, arylation, etherification, esterification, and iodination reactions.
Key words
gemfibrozil - gemfibrozil methyl ester - diaryliodonium salts - Koser’s reagent - derivatizationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1679-7753.
- Supporting Information
Publication History
Received: 26 September 2021
Accepted after revision: 27 October 2021
Accepted Manuscript online:
27 October 2021
Article published online:
29 November 2021
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