RSS-Feed abonnieren
DOI: 10.1055/a-1692-9879
Postoperative Pain Management and Perceived Patient Outcomes following Endoscopic Pituitary Surgery
Funding The project described was supported by National Institute of Health (NIH) grant no. KL2TR002490. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.Abstract
Objectives Pain management remains a point of emphasis given the ongoing opioid crisis. There are no studies in the literature interrogating opioid prescribing and use following endoscopic pituitary surgery. This study investigates provider prescribing tendency, patient utilization of analgesics, and patient outcomes regarding pain management after endoscopic pituitary surgery.
Methods We identified 100 patients undergoing endoscopic pituitary surgery at one institution from 2016 to 2018 in the electronic medical record (EMR) and state narcotic database to determine postoperative analgesic regimens. A telephone survey was used to characterize postoperative analgesic use and satisfaction with prescribed regimen.
Results Fifty-two different pain control regimens were prescribed to the study patients. Also, 93% of study patients were prescribed an opioid postoperatively. The average quantity of opioids prescribed per patient in morphine milligram equivalents (MMEs) was 625 (equivalent 83 oxycodone 5-mg tablets) with an average MME/day of 59 (equivalent 8 oxycodone 5-mg tablets). A total of 71% survey respondents who used opioids reported using <25% of their prescription. The majority of prescription narcotic users consumed >50% of their postoperative opioid intake in the first 24 to 48 hours after discharge. There were no significant differences in pain outcome between opioid users and nonopioid users.
Conclusion Vast heterogeneity exists in narcotic prescribing by providers at our institution following endoscopic pituitary surgery. Narcotic prescribing patterns exceeded most patients' analgesic needs. Opioid analgesics were not superior to nonopioids regimens in patient-reported pain outcomes in this study population.
Keywords
pain - opioids - pituitary - endoscopic - endonasal - analgesia - surgery - postoperative - prescriptionPublikationsverlauf
Eingereicht: 07. Juli 2020
Angenommen: 06. November 2021
Accepted Manuscript online:
10. November 2021
Artikel online veröffentlicht:
17. Dezember 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Centers for Disease Control and Prevention. The drug overdose epidemic: behind the numbers. Accessed November 26, 2021 at: http://www.cdc.gov/drugoverdose/data/index.html
- 2 Wilson N, Kariisa M, Seth P, Smith H, Davis NL. Centers for Disease Control and Prevention. Drug and Opioid-Involved Overdose Deaths - United States, 2017–2018. Accessed October 25, 2020 at: https://www.cdc.gov/mmwr/volumes/69/wr/mm6911a4.htm#suggestedcitation
- 3 Guy Jr. GP, Zhang K, Bohm MK. et al. Vital signs: changes in opioid prescribing in the United States, 2006-2015. Morb Mortal Wkly Rep 2017; 66 (26) 697-704
- 4 Cheung C-W, Ching Wong SS, Qiu Q, Wang X. Oral oxycodone for acute postoperative pain: a review of clinical trials. Pain Physician 2017; 20 (2S): SE33-SE52
- 5 Hoots BE, Xu L, Kariisa M. et al. Centers for Disease Control and Prevention. 2018 Annual Surveillance Report of Drug-Related Risks and Outcomes. United States. Accessed November 12, 2020 at: https://www.cdc.gov/drugoverdose/pdf/pubs/2018-cdc-drug-surveillance-report.pdf
- 6 Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg 1999; 89 (03) 652-658
- 7 Capdevila X, Barthelet Y, Biboulet P, Ryckwaert Y, Rubenovitch J, d'Athis F. Effects of perioperative analgesic technique on the surgical outcome and duration of rehabilitation after major knee surgery. Anesthesiology 1999; 91 (01) 8-15
- 8 Wells N, McCaffery M, Pasero C. Improving the quality of care through pain assessment and management. In: Hughes R. ed. Patient Safety and Quality: an Evidence-Based Handbook for Nurses. Rockville, MD: Agency for Healthcare Research and Quality; 2008
- 9 Barr J, Boulind C, Foster JD. et al. Impact of analgesic modality on stress response following laparoscopic colorectal surgery: a post-hoc analysis of a randomised controlled trial. Tech Coloproctol 2015; 19 (04) 231-239
- 10 Scott MJ, Baldini G, Fearon KC. et al. Enhanced recovery after surgery (ERAS) for gastrointestinal surgery, part 1: pathophysiological considerations. Acta Anaesthesiol Scand 2015; 59 (10) 1212-1231
- 11 Polomano RC, Fillman M, Giordano NA, Vallerand AH, Nicely KL, Jungquist CR. Multimodal analgesia for acute postoperative and trauma-related pain. Am J Nurs 2017; 117 (3, suppl 1) S12-S26
- 12 Gaskell H, Derry S, Moore RA, McQuay HJ. Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. Cochrane Database Syst Rev 2009; (03) CD002763
- 13 Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev 2013; (06) CD010210
- 14 Moore PA, Hersh EV. Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc 2013; 144 (08) 898-908
- 15 Chou R, Gordon DB, de Leon-Casasola OA. et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain 2016; 17 (02) 131-157
- 16 Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg 1993; 77 (05) 1048-1056
- 17 Gritsenko K, Khelemsky Y, Kaye AD, Vadivelu N, Urman RD. Multimodal therapy in perioperative analgesia. Best Pract Res Clin Anaesthesiol 2014; 28 (01) 59-79
- 18 Argoff CE. Recent management advances in acute postoperative pain. Pain Pract 2014; 14 (05) 477-487
- 19 Arianpour K, Nguyen B, Yuhan B, Svider PF, Eloy JA, Folbe AJ. Opioid prescription among sinus surgeons. Am J Rhinol Allergy 2018; 32 (04) 323-329
- 20 Schwartz MA, Naples JG, Kuo C-L, Falcone TE. Opioid prescribing patterns among otolaryngologists. Otolaryngol Head Neck Surg 2018; 158 (05) 854-859
- 21 Ndon S, Spock T, Torabi SJ, Manes RP. Patterns in pain and opiate use after endoscopic sinus surgery. Otolaryngol Head Neck Surg 2020; 162 (06) 969-978
- 22 Wise SK, Wise JC, DelGaudio JM. Evaluation of postoperative pain after sinonasal surgery. Am J Rhinol 2005; 19 (05) 471-477
- 23 Gray ML, Fan CJ, Kappauf C. et al. Postoperative pain management after sinus surgery: a survey of the American Rhinologic Society. Int Forum Allergy Rhinol 2018; 8 (10) 1199-1203
- 24 Sethi RKV, Miller AL, Bartholomew RA. et al. Opioid prescription patterns and use among patients undergoing endoscopic sinus surgery. Laryngoscope 2019; 129 (05) 1046-1052
- 25 Locketz GD, Brant JD, Adappa ND. et al. Postoperative opioid use in sinonasal surgery. Otolaryngol Head Neck Surg 2019; 160 (03) 402-408
- 26 Becker SD, Barbato M, Brant J. et al. American Rhinologic Society. COSM 2017. Accessed November 26, 2021 at: https://www.american-rhinologic.org/assets/docs/Meetings/2017ARSCOSMFullProgram.pdf
- 27 Svider PF, Nguyen B, Yuhan B, Zuliani G, Eloy JA, Folbe AJ. Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence-based review. Int Forum Allergy Rhinol 2018; 8 (07) 837-849
- 28 Kemppainen T, Kokki H, Tuomilehto H, Seppä J, Nuutinen J. Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery. Laryngoscope 2006; 116 (12) 2125-2128
- 29 Nguyen BK, Yuhan BT, Folbe E. et al. Perioperative analgesia for patients undergoing septoplasty and rhinoplasty: an evidence-based review. Laryngoscope 2019; 129 (06) E200-E212
- 30 Shepherd DM, Jahnke H, White WL, Little AS. Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery. J Neurosurg 2018; 128 (02) 444-451
- 31 Calculating total daily dose of opioids for safer dosage. Accessed March 26, 2021 at: https://www.cdc.gov/drugoverdose/pdf/calculating_total_daily_dose-a.pdf
- 32 Mattoo SK, Nebhinani N, Kumar BN, Basu D, Kulhara P. Family burden with substance dependence: a study from India. Indian J Med Res 2013; 137 (04) 704-711
- 33 Guy Jr. GP, Pasalic E, Zhang K. Emergency department visits involving opioid overdoses, U.S., 2010—2014. Am J Prev Med 2018; 54 (01) e37-e39
- 34 Meyer R, Patel AM, Rattana SK, Quock TP, Mody SH. Prescription opioid abuse: a literature review of the clinical and economic burden in the United States. Popul Health Manag 2014; 17 (06) 372-387
- 35 Florence CS, Zhou C, Luo F, Xu L. The economic burden of prescription opioid overdose, abuse, and dependence in the United States, 2013. Med Care 2016; 54 (10) 901-906
- 36 Bayman EO, Parekh KR, Keech J, Larson N, Vander Weg M, Brennan TJ. Preoperative patient expectations of postoperative pain are associated with moderate to severe acute pain after VATS. Pain Med 2019; 20 (03) 543-554
- 37 Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on acute pain management. Anesthesiology 2012; 116 (02) 248-273