Effects of Lipid Overload on Heart in Metabolic
                    Diseases

An Yan; Guinan Xie; Xinya Ding; Yi Wang; Liping Guo

doi:10.1055/a-1693-8356

Hormone and Metabolic Research, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Horm Metab Res 2021; 53(12): 771-778
DOI: 10.1055/a-1693-8356

Review

Effects of Lipid Overload on Heart in Metabolic Diseases

An Yan‡

¹Tianjin University of Traditional Chinese Medicine, Tianjin, China

,

Guinan Xie‡

¹Tianjin University of Traditional Chinese Medicine, Tianjin, China

,

Xinya Ding

¹Tianjin University of Traditional Chinese Medicine, Tianjin, China

,

Yi Wang

¹Tianjin University of Traditional Chinese Medicine, Tianjin, China

,

Liping Guo

²Tianjin Academy of Traditional Chinese Medicine, Tianjin, China

› Institutsangaben

Abstract

Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose in the heart, and also affects mitochondrial function. In this paper, the mechanism of lipid overload in metabolic diseases leading to cardiac energy metabolism disorder is discussed.

Key words

lipid metabolism - cardiac energy metabolism - metabolic diseases - metabolic syndrome - type 2 diabetes - diabetic cardiomyopathy

Volltext

Referenzen

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