Abstract
Metabolic diseases are often associated with lipid and glucose metabolism
abnormalities, which increase the risk of cardiovascular disease. Diabetic
cardiomyopathy (DCM) is an important development of metabolic diseases and a
major cause of death. Lipids are the main fuel for energy metabolism in the
heart. The increase of circulating lipids affects the uptake and utilization of
fatty acids and glucose in the heart, and also affects mitochondrial function.
In this paper, the mechanism of lipid overload in metabolic diseases leading to
cardiac energy metabolism disorder is discussed.
Key words
lipid metabolism - cardiac energy metabolism - metabolic diseases - metabolic syndrome - type 2 diabetes - diabetic cardiomyopathy