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Int J Sports Med 2022; 43(07): 616-624
DOI: 10.1055/a-1699-2380
Training & Testing

Association of Cardiopulmonary Exercise Capacity and Adipokines in the General Population

Frederik Lendeckel 
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
,
Stephanie Zylla 
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
3   Institute for Clinical Chemistry and Laboratory Medicine, Universitätsmedizin Greifswald, Greifswald, Germany
,
Marcello Ricardo Paulista Markus 
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
4   Institute of Community Medicine, Universitatsmedizin Greifswald, Greifswald, Germany
,
Ralf Ewert
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
,
Sven Gläser
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
5   Clinic for Internal Medicine, Vivantes Klinikum Neukölln, Berlin, Germany
,
Henry Völzke 
4   Institute of Community Medicine, Universitatsmedizin Greifswald, Greifswald, Germany
6   Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Berlin, Germany
,
Diana Albrecht
4   Institute of Community Medicine, Universitatsmedizin Greifswald, Greifswald, Germany
7   Leibniz Institute Greifswald, Leibniz Institute for Plasma Science and Technology eV, Greifswald, Germany
,
Nele Friedrich
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
3   Institute for Clinical Chemistry and Laboratory Medicine, Universitätsmedizin Greifswald, Greifswald, Germany
,
Matthias Nauck 
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
3   Institute for Clinical Chemistry and Laboratory Medicine, Universitätsmedizin Greifswald, Greifswald, Germany
,
Stephan B Felix 
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
,
Marcus Dörr 
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
,
Martin Bahls 
1   Department for Internal Medicine B, Universitätsmedizin Greifswald, Greifswald, Germany
2   Partner-site Greifswald, Deutsches Zentrum für Herz-Kreislauf-Forschung eV, Greifswald, Germany
› Author Affiliations Funding SHIP is part of the Community Medicine of the University of Greifswald, which is funded by grants from the German Federal Ministry of Education and Research for SHIP (BMBF, grant 01ZZ96030, 01ZZ0701) and German Asthma and COPD Network (COSYCONET; BMBF grant 01GI0883); the Ministry for Education, Research, and Cultural Affairs; and the Ministry for Social Affairs of the Federal State of Mecklenburg–West Pomerania. There are no relationships with industry.
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Abstract

Adipokines and cardiorespiratory fitness (CRF) are associated with the (patho)physiology of cardiometabolic diseases. Whether CRF and adipokines are related is unclear. We investigated associations of CRF with leptin, adiponectin, chemerin, resistin and vaspin. Data from the population-based Study of Health in Pomerania was used (n=1,479; median age 49 years; 51% women). Cardiopulmonary exercise testing was used to measure CRF. Circulating adipokine concentrations were measured by enzyme-linked immunosorbent assay. The association between CRF and adipokines was assessed using multivariable sex-specific quantile regression models. Higher maximum oxygen uptake was significantly associated with lower leptin (men:−0.11 ng/ml; 95%-confidence interval [CI]:−0.18 to−0.03 ng/ml; p<0.005; women:−0.17 ng/ml; 95%-CI:−0.33 to−0.02 ng/ml; p<0.05) and chemerin (men:−0.26 ng/ml; 95%-CI:−0.52 to−0.01 ng/ml; p<0.05; women:−0.41 ng/ml; 95%-CI:−0.82 to−0.01 ng/ml; p<0.05) as well as higher adiponectin concentrations (men: 0.06 µg/ml; 95%-CI: 0.02 to 0.11 µg/ml; p<0.05; women: 0.03 µg/ml; 95%-CI:−0.05 to 0.10 µg/ml; p=0.48). We found that CRF was inversely associated with leptin and chemerin in both sexes and positively associated with adiponectin only in men.

Key words

adipokines - cardio-respiratory fitness - epidemiology

Supplementary Material



Publication History

Received: 29 April 2021

Accepted: 02 November 2021

Article published online:
03 February 2022

© 2022. Thieme. All rights reserved.

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