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Klin Monbl Augenheilkd 2022; 239(02): 177-181
DOI: 10.1055/a-1699-2911
Übersicht

Zerebrale und liquorspezifische Besonderheiten beim primären Offenwinkelglaukom und Normaldruckglaukom

Artikel in mehreren Sprachen: deutsch | English
Hanspeter Esriel Killer
1   Departement Biomedizin, Universität Basel, Schweiz
2   Augenärztezentrum Aarau, Aarau, Schweiz
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Zusammenfassung

Neben dem Kammerwasser und dem Blut spielt auch der Liquor cerebrospinalis eine wesentliche Rolle in der Pathophysiologie des primären Offenwinkelglaukoms (POWG) und insbesondere auch beim Normaldruckglaukom (NDG). Neben dem Liquordruck, der eine wichtige Rolle bei der Stauungspapille spielt, ist vor allem die Zusammensetzung des Liquors sowie die Fließgeschwindigkeit von Bedeutung. Der Liquor steht sowohl mit dem Gehirn, dem Spinalkanal als auch mit dem Sehnerv im Kontakt. Bei neurodegenerativen Erkrankungen wird neben einer veränderten Zusammensetzung des Liquors auch ein eine verlangsamte Flussgeschwindigkeit als möglicher pathophysiologischer Faktor beschrieben. Auch im perioptischen Subarachnoidalraum des Sehnervs sind bei Patienten mit Normaldruckglaukom Veränderungen der Liquorzusammensetzung wie auch der Flussgeschwindigkeit beschrieben. Diese Befunde legen nahe, dass es sich beim primären POWG, insbesondere aber beim NDG um einen neurodegenerativen Prozess handeln kann.

Schlüsselwörter

Normaldruckglaukom - Liquor cerebrospinalis - Neurodegeneration - Morbus Alzheimer - primäres Offenwinkelglaukom


Publikationsverlauf

Eingereicht: 31. August 2021

Angenommen: 14. November 2021

Artikel online veröffentlicht:
24. Februar 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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