Libocedroquinone: A Promising Anticancer Lead against Lung Cancer
                    from Calocedrus Decurrens

Santhi Subramanyan; Varsha Karunakaran; Selvakumar Deepika; Anuja Joseph Gracy; Veluthoor Sheeba; Karchesy Joseph; Kaustabh Kumar Maiti; Ramavarma Luxmi Varma; Kokkuvayil Vasu Radhakrishnan

doi:10.1055/a-1699-8748

Planta Medica International Open, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Planta Medica International Open 2022; 9(01): e54-e59
DOI: 10.1055/a-1699-8748

Original Papers

Libocedroquinone: A Promising Anticancer Lead against Lung Cancer from Calocedrus Decurrens

Santhi Subramanyan

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

²Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

,

Varsha Karunakaran

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

²Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

,

Selvakumar Deepika

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

,

Anuja Joseph Gracy

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

²Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

,

Veluthoor Sheeba

³CoreValleys Herbal Technologies, Kozhikode, India

,

Karchesy Joseph

⁴Wood Science and Engineering, Oregon State University, Corvallis, OR, USA

,

Kaustabh Kumar Maiti

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

²Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

,

Ramavarma Luxmi Varma

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

²Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

,

Kokkuvayil Vasu Radhakrishnan

¹Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, India

²Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

› Institutsangaben

Abstract

A focus on evaluating anticancer potency of various extracts of the heartwood of Calocedrus decurrens against human lung adenocarcinoma (A549) cell line was performed using in vitro MTT assay. The hexane extract displayed excellent cytotoxic effect, and the phytochemical investigation of the hexane and acetone extracts resulted in the isolation of five major compounds. The structure of the compounds was established as libocedrol (1), thymoquinone (2), libocedroquinone (3), diethylphthalate (4), and (1 R, 2 R, 4 R)-p-menthane-1,2,4-triol (5). Compounds 4 and 5 are reported for the first time from the Calocedrus genus. Compounds 1–3 were evaluated for their cytotoxicity against the lung cancer cell line along with a healthy control. Compound 3 was more potent than other compounds against the A549 cell line with an IC₅₀ of 4.8 µM at 24 h. Moreover, compound 3 exhibited less toxicity with the normal lung fibroblast cell line WI-38. This is the first anticancer study of the species Calocedrus decurrens.

Key words

Calocedrus decurrens - Cupressaceae - libocedroquinone - cytotoxicity - lung cancer

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Referenzen

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