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CC BY 4.0 · TH Open 2021; 05(04): e591-e597
DOI: 10.1055/a-1704-1022
Letter to the Editor

Global Thrombosis Test: Occlusion Is Attributable to Shear-Induced Platelet Thrombus Formation

Diana A. Gorog 
1   Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom
2   Clinical Pharmaceutical and Biological Science, School of Life and Medical Science, University of Hertfordshire, United Kingdom
,
Junichiro Yamamoto
3   Faculty of Nutrition, Kobe Gakuin University, Kobe, Japan
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We read the paper by Clavería and co-workers with interest.[1] We strongly believe that the conclusions of their paper, suggesting that occlusion (occlusion time (OT)) in the global thrombosis test (GTT) is due to coagulation, rather than shear-induced platelet thrombus formation, is wrong and the evidence and arguments they present are fundamentally flawed.

The authors have made major errors both in the approach to their experiments and in their interpretations of their results. The evidence which they demonstrate, shows that occlusion in the GTT is, in fact, caused by high shear-induced platelet thrombus formation, the complete opposite to their interpretation of their results. We set out below the evidence for that.



Publication History

Received: 11 October 2021

Accepted: 16 November 2021

Accepted Manuscript online:
23 November 2021

Article published online:
15 February 2022

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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