Download PDF
Schmerz.Therapie 2022; 5(01): 9-17
DOI: 10.1055/a-1708-4241
Schwerpunkt

Noziplastischer Schmerz

Walter Magerl
› Further Information
    Permissions and Reprints

Noziplastische Schmerzen sind eine dritte mechanistische Schmerzkategorie. Anders als bei nozizeptiven oder neuropathischen Schmerzen findet sich weder eine Gewebeschädigung, noch eine Läsion im somatosensorischen Nervensystem. Die IASP-Definition erklärt die Pathophysiologie als veränderte Nozizeption infolge einer Modulation der Reizverarbeitung. Die Breite der Definition und ihre nur entfernte Verknüpfung mit neurophysiologischen Mechanismen machen sie allerdings potentiell zum Sammelbecken unspezifischer und unklarer Befunde.

Publication History

Article published online:
05 January 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Edwards RR, Dworkin RH, Turk DC. et al. Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain 2016; 157: 1851-1871
    CrossrefPubMedSearch in Google Scholar
  • 2 International Association for the Study of Pain (IASP). IASP Terminology. IASP PAIN Terms. Last Updated December 14, 2017. Im Internet (Stand: 28.11.2021): https://www.iasp-pain.org/resources/terminology/
  • 3 Perl ER. Ideas about pain, a historical view. Nat Rev Neurosci 2007; 8: 71-80
    CrossrefPubMedSearch in Google Scholar
  • 4 Raja SN, Meyer RA, Campbell JN. Peripheral mechanisms of somatic pain. Anesthesiology 1988; 68: 571-590
    CrossrefPubMedSearch in Google Scholar
  • 5 Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature 1983; 306(5944): 686-688
    CrossrefPubMedSearch in Google Scholar
  • 6 Treede RD, Meyer RA, Raja SN. et al. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol 1992; 38 (04) 397-421
    CrossrefPubMedSearch in Google Scholar
  • 7 Randić M, Jiang MC, Cerne R. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord. J Neurosci 1993; 13: 5228-5241
    CrossrefPubMedSearch in Google Scholar
  • 8 Ikeda H, Heinke B, Ruscheweyh R. et al. Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia. Science 2003; 299: 1237-1240
    CrossrefPubMedSearch in Google Scholar
  • 9 Ji RR, Kohno T, Moore KA. et al. Central sensitization and LTP: do pain and memory share similar mechanisms?. Trends Neurosci 2003; 26 (12) 696-705
    CrossrefPubMedSearch in Google Scholar
  • 10 Klein T, Magerl W, Hopf HC. et al. Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans. J Neurosci 2004; 24: 964-971
    CrossrefPubMedSearch in Google Scholar
  • 11 Ziegler EA, Magerl W, Meyer RA. et al. Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to A-fibre nociceptor input. Brain 1999; 122: 2245-2257
    CrossrefPubMedSearch in Google Scholar
  • 12 Klein T, Magerl W, Treede RD. Perceptual correlate of nociceptive long-term potentiation (LTP) in humans shares the time course of early-LTP. J Neurophysiol 2006; 96: 3551-3555
    CrossrefPubMedSearch in Google Scholar
  • 13 Lang S, Klein T, Magerl W. et al. Modality-specific sensory changes in humans after the induction of long-term potentiation (LTP) in cutaneous nociceptive pathways. Pain 2007; 128: 254-263
    CrossrefPubMedSearch in Google Scholar
  • 14 Pfau DB, Klein T, Putzer D. et al. Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity. Pain 2011; 152: 1532-1539
    CrossrefPubMedSearch in Google Scholar
  • 15 Woolf CJ, Bennett GJ, Doherty M. et al. Towards a mechanism-based classification of pain?. Pain 1998; 77: 227-229
    CrossrefPubMedSearch in Google Scholar
  • 16 Vardeh D, Mannion RJ, Woolf CJ. Toward a Mechanism-Based Approach to Pain Diagnosis. J Pain 2016; 17 (Suppl) T50-69
    CrossrefPubMedSearch in Google Scholar
  • 17 Baron R, Maier C, Attal N. et al. Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain 2017; 158: 261-272
    CrossrefPubMedSearch in Google Scholar
  • 18 Treede RD, Jensen TS, Campbell JN. et al. Neuropathic pain: Redefinition and a grading system for clinical and research purposes. Neurology 2008; 70: 1630-1635
    CrossrefPubMedSearch in Google Scholar
  • 19 Dyck PJ, Dyck PJ, Larson TS. et al. Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve growth factor study group. Diabetes Care 2000; 23 (04) 510-517
    CrossrefPubMedSearch in Google Scholar
  • 20 Rolke R, Baron R, Maier C. et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 2006; 123 (03) 231-243
    CrossrefPubMedSearch in Google Scholar
  • 21 Maier C, Baron R, Tölle TR. et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 2010; 150: 439-450
    CrossrefPubMedSearch in Google Scholar
  • 22 Backonja MM, Attal N, Baron R. et al. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain 2013; 154: 1807-1819
    CrossrefPubMedSearch in Google Scholar
  • 23 European Medical Agencies (EMA) 2016. Guideline on the clinical development of medicinal products intended for the treatment of pain. (EMA/CHMP/970057/2011, effective July 1, 2017).
  • 24 Freynhagen R, Rolke R, Baron R. et al. Pseudoradicular and radicular low-back pain – a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 2008; 135: 65-74
    CrossrefPubMedSearch in Google Scholar
  • 25 Roussel NA, Nijs J, Meeus M. et al. Central sensitization and altered central pain processing in chronic low back pain: fact or myth?. Clin J Pain 2013; 29: 625-638
    CrossrefPubMedSearch in Google Scholar
  • 26 Yunus MB. Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin Arth Rheum 2008; 37: 339-352
    CrossrefPubMedSearch in Google Scholar
  • 27 Nijs J, Torres-Cueco R, van Wilgen PC. et al. Applying modern pain neuroscience in clinical practice: criteria for the classification of central sensitization pain. Pain Physician 2014; 17 (05) 447-457
    CrossrefPubMedSearch in Google Scholar
  • 28 Nijs J, Apeldoorn A, Hallegraeff H. et al. Low back pain: Guidelines for the clinical classification of predominant neuropathic, nociceptive, or central sensitization pain. Pain Phys 2015; 18: E333-E346
    CrossrefPubMedSearch in Google Scholar
  • 29 Pfau DB, Krumova EK, Treede RD. et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): reference data for the trunk and application in patients with chronic postherpetic neuralgia. Pain 2014; 155: 1002-1015
    CrossrefPubMedSearch in Google Scholar
  • 30 Iannetti GD, Baumgärtner U, Tracey I. et al. Pinprick-evoked brain potentials: a novel tool to assess central sensitization of nociceptive pathways in humans. J Neurophysiol 2013; 110: 1107-1116
    CrossrefPubMedSearch in Google Scholar
  • 31 Kosek E, Cohen M, Baron R. et al. Do we need a third mechanistic descriptor for chronic pain states?. Pain 2016; 157 (07) 1382-1386
    CrossrefPubMedSearch in Google Scholar
  • 32 Walsh DA. Nociplastic pain: helping to explain disconnect between pain and pathology. Pain 2021; 162: 2627-2628
    CrossrefPubMedSearch in Google Scholar
  • 33 Misery L. Pruriplastic Itch – A Novel Pathogenic Concept in Chronic Pruritus. Front Med 2021; 7: 615118
    CrossrefPubMedSearch in Google Scholar
  • 34 Aydede M, Shriver A. Recently introduced definition of “nociplastic pain” by the International Association for the Study of Pain needs better formulation. Pain 2018; 159: 1176-1177
    CrossrefPubMedSearch in Google Scholar
  • 35 Kosek E, Clauw D, Nijs J. et al. Chronic nociplastic pain affecting the musculoskeletal system: Clinical criteria and grading system. Pain 2021; 162: 2629-2634
    CrossrefPubMedSearch in Google Scholar
  • 36 Nijs J, Lahousse A, Kapreli E. et al. Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future. J Clin Med 2021; 10: 3203
    Search in Google Scholar
  • 37 Hoeijmakers JG, Faber CG, Lauria G. et al. Small-fibre neuropathies – advances in diagnosis, pathophysiology and management. Nat Rev Neurol 2012; 8: 369-379
    CrossrefPubMedSearch in Google Scholar
  • 38 Lauria G, Ziegler D, Malik R. et al. The role of sodium channels in painful diabetic and idiopathic neuropathy. Curr Diab Rep 2014; 14: 538
    CrossrefPubMedSearch in Google Scholar
  • 39 Quintner J, Cohen M. The hijacking of “nociplastic”. Painlosophy 2021. Im Internet (Stand: 28.11.2021): https://painlosophy.wordpress.com/2021/06/08/the-highjacking-of-nociplastic/
  • 40 Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet 2021; 397: 2082-2097
    CrossrefPubMedSearch in Google Scholar
  • 41 Adler M, Taxer B. Quantitative sensorische Testung im Rahmen neuropathischer Schmerzen und ihre Bedeutung für die Physiotherapie. Schmerz 2021; Online ahead of print.
    CrossrefPubMedSearch in Google Scholar
  • 42 Magerl W, Krumova EK, Baron R. et al. Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data. Pain 2010; 151 (03) 598-605
    CrossrefPubMedSearch in Google Scholar
  • 43 Reimer M, Forstenpointner J, Hartmann A. et al. Sensory bedside testing: a simple stratification approach for sensory phenotyping. Pain Rep 2020; 5: e820
    CrossrefPubMedSearch in Google Scholar
  • 44 Nilges P, Rief W. F45.41 Chronische Schmerzstörung mit somatischen und psychischen Faktoren. Eine Kodierhilfe. Schmerz 2010; 24: 209-212
    CrossrefPubMedSearch in Google Scholar
  • 45 Fitzcharles MA, Cohen SP, Clauw DJ. et al. Nociplastic pain: towards an understanding of prevalent pain conditions. Lancet 2021; 397: 2098-2110
    CrossrefPubMedSearch in Google Scholar
  • 46 Edwards RR, Almeida DM, Klick B. et al. Duration of sleep contributes to next-day pain report in the general population. Pain 2008; 137: 202-207
    CrossrefPubMedSearch in Google Scholar
  • 47 Popkirov S, Enax-Krumova EK, Mainka T. et al. Functional pain disorders – more than nociplastic pain. NeuroRehabilitation 2020; 47: 343-353
    CrossrefPubMedSearch in Google Scholar
  • 48 Treede RD, Rief W, Barke A. et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International classification of diseases (ICD-11). PAIN 2019; 160: 19-27
    CrossrefPubMedSearch in Google Scholar
  • 49 Kemp HI, Laycock H, Costello A. et al. Chronic pain in critical care survivors: a narrative review. Br J Anaesth 2019; 123: e372-e384
    CrossrefPubMedSearch in Google Scholar
  • 50 Chimenti RL, Hall MM, Dilger CP. et al. Local Anesthetic Injection Resolves Movement Pain, Motor Dysfunction, and Pain Catastrophizing in Individuals With Chronic Achilles Tendinopathy: A Nonrandomized Clinical Trial. J Orthop Sports Phys Ther 2020; 50: 334-343
    CrossrefPubMedSearch in Google Scholar
  • 51 Xie Y, Thomas L, Barbero M. et al. Heightened pain facilitation rather than impaired pain inhibition distinguishes those with moderate/severe disability in work-related neck pain. Pain 2021; 162: 2225-2236
    CrossrefPubMedSearch in Google Scholar
  • 52 Elgueta-Cancino E, Sheeran L, Salomoni S. et al. Characterisation of motor cortex organisation in patients with different presentations of persistent low back pain. Eur J Neurosci 31.10.2021;
    CrossrefPubMedSearch in Google Scholar
  • 53 Larkin TE, Kaplan CM, Schrepf A. et al. Altered network architecture of functional brain communities in chronic nociplastic pain. Neuroimage 2021; 226: 117504
    CrossrefPubMedSearch in Google Scholar
  • 54 Sandström A, Ellerbrock I, Löfgren M. et al. Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis. Pain 2021; Online ahead of print.
    CrossrefPubMedSearch in Google Scholar
  • 55 Alshelh Z, Brusaferri L, Saha A. et al. Neuro-immune signatures in chronic low back pain subtypes. Brain 2021; awab336 Online ahead of print.
    CrossrefPubMedSearch in Google Scholar
  • 56 Kratz AL, Whibley D, Alschuler KN. et al. Characterizing chronic pain phenotypes in multiple sclerosis: a nationwide survey study. Pain 2021; 162: 1426-1433
    CrossrefPubMedSearch in Google Scholar
  • 57 Ferro Moura Franco K, Lenoir D, Dos Santos Franco YR. et al. Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis. Eur J Pain 2021; 25: 51-70
    CrossrefPubMedSearch in Google Scholar
  • 58 Shraim MA, Massé-Alarie H, Hall LM. et al. Systematic Review and Synthesis of Mechanism-based Classification Systems for Pain Experienced in the Musculoskeletal System. Clin J Pain 2020; 36: 793-812
    CrossrefPubMedSearch in Google Scholar