Update nuklearmedizinische Bildgebung von Gehirntumoren und -metastasen

Karl-Josef Langen; Norbert Galldiks

doi:10.1055/a-1712-6180

Angewandte Nuklearmedizin, Inhaltsverzeichnis

Angewandte Nuklearmedizin 2022; 45(04): 351-359
DOI: 10.1055/a-1712-6180

Nuklearmedizinische Hirnbildgebung

Übersicht

Update nuklearmedizinische Bildgebung von Gehirntumoren und -metastasen

Update nuclear medicine imaging of brain tumours and metastases

Karl-Josef Langen

¹Institut für Neurowissenschaften und Medizin, Forschungszentrum Jülich, Jülich, Deutschland

²Klinik für Nuklearmedizin, Universtitätsklinikum Aachen, Aachen, Deutschland

,

Norbert Galldiks

¹Institut für Neurowissenschaften und Medizin, Forschungszentrum Jülich, Jülich, Deutschland

³Klinik und Poliklinik für Neurologie, Universitätsklinikum Köln (AöR), Köln, Deutschland

› Institutsangaben

Abstract

Zusammenfassung

In der Hirntumordiagnostik hat die PET mit radioaktiv markierten Aminosäuren in den letzten Jahren zunehmend an Bedeutung gewonnen und ist in vielen Zentren bereits als ergänzendes Diagnoseverfahren neben der MRT etabliert. Die Aminosäure-PET bietet wichtige Zusatzinformationen bei der diagnostischen Zuordnung unklarer zerebraler Läsionen und eine verbesserte Darstellung der Tumorausdehnung von zerebralen Gliomen, welche bei der Prognostik und Therapieplanung wichtige Hilfestellung bieten kann. Des Weiteren kann mit der Aminosäure-PET sowohl bei Gliomen als auch bei Hirnmetastasen eine Tumorprogression oder -rezidiv mit hoher Genauigkeit von unspezifischen posttherapeutischen Veränderungen in der MRT differenziert werden sowie Therapieeffekte zuverlässiger und frühzeitiger beurteilt werden.

Abstract

PET using radiolabelled amino acids has gained increasing interest in the diagnostics of brain tumors in the last years and has been established in many neurooncological centers as a complementary diagnostic tool to MRI. Amino acid PET offers important additional information in the diagnosis and prognosis of unclear brain lesions and an improved delineation of tumor extent of cerebral gliomas, which is helpful for therapy planning. Furthermore, amino acid imaging helps to differentiate tumor progression or recurrence from unspecific posttherapeutic changes for both cerebral gliomas and brain metastases and to detect the metabolic response during tumor therapy earlier than with conventional MRI.

Schlüsselwörter

PET - Hirntumore - Hirnmetastasen - FDG - Aminosäuren - MET - FET - FDOPA

Keywords

PET - brain tumors - brain metastases - FDG - amino acids - MET - FET - FDOPA

Volltext

Referenzen

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