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Klin Padiatr 2022; 234(05): 305-308
DOI: 10.1055/a-1717-2234
Short Communication

Mepolizumab Treatment in Severe Pediatric Asthma: First Multicentric Real-World Data

Mepolizumab bei pädiatrischem schwerem Asthma: erste multizentrische Daten aus der Praxis
Martin Wetzke‡
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Dominik Funken  ‡
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Frank O. Ahrens
2   Pediatrics, AKK Altona Children's Hospital, Hamburg, Germany
,
Monika Gappa
3   Pediatrics, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany
,
Gesine Hansen
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Cordula Koerner-Rettberg
4   Pediatrics, Children’s Hospital Wesel, Wesel, Germany
,
Holger Koester
5   Pediatrics, Oldenburg Hospital University Department Pediatrics and Adolescent Medicine, Oldenburg, Germany
,
Johannes Schulze
6   Pediatric Pneumology, Hospital of the Goethe University Frankfurt Centre for Paediatrics and Adolescent Medicine, Frankfurt am Main, Germany
,
Nicolaus Schwerk
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
,
Stefan Zielen
6   Pediatric Pneumology, Hospital of the Goethe University Frankfurt Centre for Paediatrics and Adolescent Medicine, Frankfurt am Main, Germany
,
Christine Happle
1   Pediatric Ped. Pneumology, Allergology, Neonatology, Hannover Medical School, Hannover, Germany
7   Biomedical Research in Endstage and Obstruktive Lung Disease Hannover BREATH, German Center for Lung Research, Hannover, Germany
8   Excellence Cluster Infection Research RESIST, Hannover, Germany
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Introduction

Asthma is associated with high morbidity and healthcare costs around the globe. Severe asthma in children is rare, and treatment with biologicals is seldom prescribed in pediatric asthma (Santos-Valente E., ERJ Open Res. 2021 Aug 16;7(3):00143-2021). Although global guidelines recommend using biologicals in severely asthmatic children, knowledge on real-life application in pediatrics is scarce. To change this situation, we aimed to analyze application and effect of anti-IL5 (Mepolizumab) therapy in childhood asthma in six pediatric centers in Germany.



Publication History

Article published online:
22 March 2022

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