Update Breast Cancer 2021 Part 4 – Prevention and Early Stages

Christoph Thomssen; Tanja N. Fehm; Elmar Stickeler; Peter A. Fasching; Wolfgang Janni; Cornelia Kolberg-Liedtke; Hans-Christian Kolberg; Diana Lüftner; Volkmar Müller; Florian Schütz; Erik Belleville; Simon Bader; Michael Untch; Manfred Welslau; Marc Thill; Andreas D. Hartkopf; Hans Tesch; Nina Ditsch; Michael P. Lux; Achim Wöckel; Bahriye Aktas; Andreas Schneeweiss; Rachel Würstlein

doi:10.1055/a-1724-9639

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(02): 206-214
DOI: 10.1055/a-1724-9639

GebFra Science

Review/Übersicht

Update Breast Cancer 2021 Part 4 – Prevention and Early Stages

Article in several languages: English | deutsch

Christoph Thomssen

¹Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

,

Tanja N. Fehm

²Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany

,

Elmar Stickeler

³Department of Gynecology and Obstetrics, RWTH University Hospital Aachen, Aachen, Germany

,

Peter A. Fasching

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Wolfgang Janni

⁵Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany

,

Cornelia Kolberg-Liedtke

⁶Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany

⁷palleos healthcare, Wiesbaden, Germany

⁸Phaon Scientific, Wiesbaden, Germany

,

Hans-Christian Kolberg

⁹Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany

,

Diana Lüftner

¹⁰Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany

,

Volkmar Müller

¹¹Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany

,

Florian Schütz

¹²Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany

,

Erik Belleville

¹³ClinSol GmbH & Co. KG, Würzburg, Germany

,

Simon Bader

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

,

Michael Untch

¹⁴Clinic for Gynecology and Obstetrics, Breast Cancer Center, Genecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany

,

Manfred Welslau

¹⁵Onkologie Aschaffenburg, Aschaffenburg, Germany

,

Marc Thill

¹⁶Agaplesion Markus Krankenhaus, Department of Gynecology and Gynecological Oncology, Frankfurt am Main, Germany

,

Andreas D. Hartkopf

¹⁷Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany

,

Hans Tesch

¹⁸Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany

,

Nina Ditsch

¹⁹Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany

,

Michael P. Lux

²⁰Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany

,

Achim Wöckel

²¹Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany

,

Bahriye Aktas

²²Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Leipzig, Leipzig, Germany

,

Andreas Schneeweiss

²³National Center for Tumor Diseases (NCT), Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

,

Rachel Würstlein

²⁴Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, Munich, Germany

› Author Affiliations

Abstract

This past year has seen new and effective options for further improving treatment outcome in many patients with early-stage breast cancer. Patients with hormone receptor-positive disease benefited significantly from the addition of the CDK4/6 inhibitor abemaciclib to endocrine adjuvant therapy. In triple-negative disease, data were presented for two treatment regimens. Patients with advanced disease (stage 2 and 3) benefit from neoadjuvant treatment with the immune checkpoint inhibitor pembrolizumab in combination with standard chemotherapy, regardless of PD-L1 expression. When neoadjuvant therapy has failed to achieve the desired remission in BRCA1 and BRCA2 mutations, the administration of the PARP inhibitor olaparib has demonstrated an impressive response. Other data address translational issues in HER2-positive breast cancer and neoadjuvant therapy approaches with the oral SERD giredestrant and the PARP inhibitor talazoparib. This review presents and analyses the findings of this yearʼ s most important study outcomes.

Key words

BRCA (breast cancer associated gene) - breast - genetics - Her-2/neu (human epidermal growth factor receptor) - hormonal receptor - breast cancer

Full Text

References

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