Prevalence of SARS-CoV-2 in Pregnant Women Assessed by RT-PCR in Franconia, Germany: First Results of the SCENARIO Study (SARS-CoV-2 prEvalence in pregNAncy and at biRth In
					FrancOnia)

Alexander Hein; Sven Kehl; Lothar Häberle; Carsten Tiemann; Rebecca Peuker; Denise Mereutanu; Florian M. Stumpfe; Florian Faschingbauer; Kirstin Meyer-Schlinkmann; Martin C. Koch; Franz Kainer; Ulf Dammer; Hanna Philipp; Carolin Kladt; Michael G. Schrauder; Stefan Weingärtler; Volker Hanf; Arndt Hartmann; Matthias Rübner; Holm Schneider; Jos Lelieveld; Matthias W. Beckmann; Lena A. Wurmthaler; Peter A. Fasching; Michael O. Schneider

doi:10.1055/a-1727-9672

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(02): 226-234
DOI: 10.1055/a-1727-9672

GebFra Science

Original Article

Prevalence of SARS-CoV-2 in Pregnant Women Assessed by RT-PCR in Franconia, Germany: First Results of the SCENARIO Study (SARS-CoV-2 prEvalence in pregNAncy and at biRth In FrancOnia)

Prävalenz von SARS-CoV-2 bei schwangeren Frauen ermittelt durch RT-PCR in Franken, Deutschland: erste Ergebnisse der SCENARIO-Studie (SARS-CoV-2 prEvalence in pregNAncy and at biRth In FrancOnia)

Alexander Hein

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Sven Kehl

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Lothar Häberle

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Carsten Tiemann

²MVZ Labor Krone GbR, Bad Salzuflen, Germany

,

Rebecca Peuker

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Denise Mereutanu

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Florian M. Stumpfe

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Florian Faschingbauer

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Kirstin Meyer-Schlinkmann

²MVZ Labor Krone GbR, Bad Salzuflen, Germany

,

Martin C. Koch

³Department of Gynaecology and Obstetrics, ANregiomed Klinikum Ansbach, Ansbach, Germany

,

Franz Kainer

⁴Department of Gynaecology and Obstetrics, Klinik Hallerwiese, Nürnberg, Germany

,

Ulf Dammer

⁵Department of Gynaecology and Obstetrics, St. Theresien-Krankenhaus, Nürnberg, Germany

,

Hanna Philipp

⁶Department of Gynaecology and Obstetrics, REGIOMED Klinikum Coburg, Coburg, Germany

,

Carolin Kladt

⁷Department of Gynaecology and Obstetrics, Clinic Bayreuth, Bayreuth, Germany

,

Michael G. Schrauder

⁸Department of Gynaecology and Obstetrics, Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Germany

,

Stefan Weingärtler

⁹Department of Gynaecology and Obstetrics, Klinikum Forchheim-Fränkische Schweiz, Forchheim, Germany

,

Volker Hanf

¹⁰Department of Gynaecology and Obstetrics, Klinikum Fürth, Fürth, Germany

,

Arndt Hartmann

¹¹Institute of Pathology, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Matthias Rübner

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Holm Schneider

¹²Department of Pediatrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Jos Lelieveld

¹³Max-Planck Institut für Chemie, Mainz, Germany

,

Matthias W. Beckmann

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Lena A. Wurmthaler

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Peter A. Fasching

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

,

Michael O. Schneider

¹Department of Gynaecology and Obstetrics, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

› Author Affiliations

Abstract

Purpose Detection of SARS-CoV-2-infected pregnant women admitted to maternity units during a pandemic is crucial. In addition to the fact that pregnancy is a risk factor for severe COVID-19 and that medical surveillance has to be adjusted in infected women and their offspring, knowledge about infection status can provide the opportunity to protect other patients and healthcare workers against virus transmission. The aim of this prospective observational study was to determine the prevalence of SARS-CoV-2 infection among pregnant women in the hospital setting.

Material and Methods All eligible pregnant women admitted to the nine participating hospitals in Franconia, Germany, from 2 June 2020 to 24 January 2021 were included. COVID-19-related symptoms, secondary diseases and pregnancy abnormalities were documented. SARS-CoV-2 RNA was detected by RT-PCR from nasopharyngeal swabs. The prevalence of acute SARS-CoV-2 infection was estimated by correcting the positive rate using the Rogan–Gladen method. The risk of infection for healthcare workers during delivery was estimated using a risk calculator.

Results Of 2414 recruited pregnant women, six were newly diagnosed RT-PCR positive for SARS-CoV-2, which yielded a prevalence of SARS-CoV-2 infection of 0.26% (95% CI, 0.10 – 0.57%). Combining active room ventilation and wearing FFP2 masks showed an estimated reduction of risk of infection for healthcare workers in the delivery room to < 1%.

Conclusions The prevalence of newly diagnosed SARS-CoV-2 infection during pregnancy in this study is low. Nevertheless, a systematic screening in maternity units during pandemic situations is important to adjust hygienic and medical management. An adequate hygienic setting can minimise the calculated infection risk for medical healthcare workers during patientsʼ labour.

Zusammenfassung

Zielsetzung Das Erkennen von SARS-CoV-2-Infektionen bei schwangeren Frauen, die während der Pandemie in eine geburtshilfliche Abteilung aufgenommen werden, ist essenziell. Bekanntlich stellt die Schwangerschaft einen Risikofaktor für die Entwicklung einer schweren COVID-19-Erkrankung dar, und die medizinische Überwachung von infizierten Frauen und ihren Kindern muss dementsprechend angepassst werden. Das Wissen um den Infektionsstatus von Patientinnen macht es möglich, andere Patientinnen und das medizinische Fachpersonal vor einer Übertragung des Virus zu schützen. Ziel dieser prospektiven Beobachungsstudie war es, die Prävalenz von SARS-CoV-2-Infektionen bei schwangeren Frauen im Krankenhaus zu bestimmen.

Material und Methoden Alle schwangeren Frauen, die in einem der 9 teilnehmenden Krankenhäuser in Franken, Deutschland, zwischen dem 2. Juni 2020 und dem 24. Januar 2021 vorstellig waren, wurden in die Studie aufgenommen. COVID-19-bedingte Symptome, sekundäre Erkrankungen und Schwangerschaftsanomalien wurden dokumentiert. Die mit nasopharyngealen Abstrichen entnommene SARS-CoV-2-RNA wurde mittels RT-PCR detektiert. Ausgehend von der Rate positiver Fälle wurde die wahre Prävalenz von akuten SARS-CoV-2-Infektionen mit der Rogan–Gladen-Methode geschätzt. Das Infektionsrisiko für das medizinische Fachpersonal während der Entbindung wurde unter Zuhilfenahme eines Risikoberechners geschätzt.

Ergebnisse Bei 6 von insgesamt 2414 in die Studie rekrutierten schwangeren Frauen wurde nach einer RT-PCR-Diagnostik eine SARS-CoV-2-Infektion erstdiagnostiziert. Das entspricht einer Prävalenz von SARS-CoV-2-Infektionen von 0,26% (95%-KI 0,10 – 0,57%). Eine aktive Raumbelüftung in Kombination mit dem Tragen von FFP2-Masken verringerte das geschätzte Risiko einer Infektion für das im Entbindungssaal tätige medizinische Fachpersonal auf < 1%.

Schlussfolgerungen Die Prävalenz einer neuen SARS-CoV-2-Infektion während der Schwangerschaft war in dieser Studie gering. Trotzdem ist es wichtig, während der Pandemie systematische Untersuchungen in geburtshilflichen Abteilungen durchzuführen, um die Hygienemaßnahmen und die medizinische Betreuung im Falle einer Infektion anzupassen. Angemessene Infektionsschutzmaßnahmen können das kalkulierte Risiko für das medizinische Fachpersonal während der Geburtsbetreuung minimieren.

Key words

SARS-CoV-2 - COVID-19 - pregnancy - prevalence - infection

Schlüsselwörter

SARS-CoV-2 - COVID-19 - Schwangerschaft - Prävalenz - Infektion

Full Text

References

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