Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes

Abstract

In recent years, transition-metal-catalyzed enantioselective C–H bond functionalization has emerged as a powerful and attractive synthetic approach to access silicon-stereogenic centers, which provides impetus for the innovation of chiral organosilicon chemistry. This short review summarizes recent advances in the construction of silicon-stereogenic silanes via transition-metal-catalyzed enantioselective C–H functionalization. We endeavor to highlight the great potential of this methodology and hope that this review will shed light on new perspectives and inspire further research in this emerging area.

1 Introduction

2 Enantioselective C–H Functionalization Induced by Oxidative Addition­ of an Aryl-OTf Bond

3 Enantioselective C–H Functionalization Induced by Oxidative Addition­ of a Silacyclobutane

4 Directing-Group-Assisted Enantioselective C–H Functionalization

5 Enantioselective Dehydrogenative C–H/Si–H Coupling

5.1 Enantioselective C(sp²)–H Silylation

5.2 Enantioselective C(sp³)–H Silylation

6 Summary and Outlook

Key words

asymmetric catalysis - enantioselective C–H functionalization - silicon-stereogenic silanes - C–H silylation - organosilicon compounds

Publication History

Received: 07 December 2021

Accepted after revision: 03 January 2022

Accepted Manuscript online:
03 January 2022

Article published online:
15 February 2022

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