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DOI: 10.1055/a-1737-8610
A Homocoupling Approach to the Key Dione of CyMe4-BTPhen – Vital Ligands for Nuclear Clean-Up by the SANEX Process
The work was supported by a grant of the Engineering and Physical Sciences Research Council (EPSRC) (EP/S011935/1, ATLANTIC: Accident ToLerANT fuels In reCycling). J.W. was supported by a grant of the Engineering and Physical Sciences Research Council (EPSRC) (EP/R014833/1, Asymmetric Catalytic Photochemistry).
Abstract
CyMe4-BTPhen and CyMe4-BTBP are the principal ligand systems used in Europe for the separation of actinides from lanthanides as a part of the SANEX process for nuclear recycling and reprocessing. We present a new approach to the synthesis of the CyMe4 fragment beginning from readily available hydroxypivalic acid. It features a cobalt-catalysed homocoupling of a neopentyl bromide to provide the key bisester precursor, thereby avoiding the requirement for technically challenging low-temperature LDA-mediated aldol chemistries.
Key words
homocoupling - catalysis - nuclear clean-up - elemental separations - SANEX process - accident tolerant fuelSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1737-8610.
- Supporting Information
Publication History
Received: 21 December 2021
Accepted after revision: 11 January 2022
Accepted Manuscript online:
12 January 2022
Article published online:
31 January 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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