Recent Advances in Construction of C(sp²)–O Bonds via Aryne Participated Multicomponent Coupling Reactions

Abstract

Aryne chemistry is a powerful synthetic technique that forms new bonds to aromatic rings. The recent resurgence of aryne-based multicomponent coupling strategies has led to an influx of methodologies for the mild synthesis of arene derivatives. In particular, these innovative discoveries broaden and streamline approaches toward phenol ether motifs, which are a prevalent structural component across a broad range of chemistry related research fields. Herein, this review aims to provide a comprehensive overview of the recent progress in the construction of C(sp²)–O bonds via aryne-induced multicomponent reactions. Special attention has been paid to reaction design and mechanistic pathways.

1 Introduction

2 Insertion-Based MCRs

3 Nucleophilic-Addition-Based MCRs

4 Cycloaddition-Based MCRs

5 Summary

Key words

C(sp²)–O bonds - arynes - multicomponent coupling reaction - phenyl ether derivatives - insertion - nucleophilic addition - cyclo­addition

Publication History

Received: 16 December 2021

Accepted after revision: 24 January 2022

Accepted Manuscript online:
24 January 2022

Article published online:
05 April 2022

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