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Synthesis 2022; 54(12): 2876-2884
DOI: 10.1055/a-1755-4700
DOI: 10.1055/a-1755-4700
paper
Iridium-Catalyzed Acceptorless Dehydrogenative Coupling of 2-Aminoarylmethanols with Amides or Nitriles to Synthesize Quinazolines
This work was supported by the National Natural Science Foundation of China (21962004), Jiangxi Provincial Department of Science and Technology (20192BAB203004), and the Fundamental Research Funds for Gannan Medical University (QD201810, TD2021YX05) for financial support.
Abstract
An efficient iridium-catalyzed acceptorless dehydrogenative coupling (ADC) reaction for the preparation of various quinazolines from 2-aminoarylmethanols and amides or nitriles had been developed. A wide range of substituted 2-aminobenzyl alcohols and (hetero)aryl or alkyl benzamides and nitriles were well compatible to afford various quinazolines in excellent yields. Merits of this new strategy are the high atom-economy, mild reaction conditions, and simple operation, and the methodology is suitable for a variety of substrates.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1755-4700.
- Supporting Information
Publication History
Received: 31 December 2021
Accepted after revision: 31 January 2022
Accepted Manuscript online:
31 January 2022
Article published online:
22 March 2022
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