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kleintier konkret 2022; 25(02): 8-20
DOI: 10.1055/a-1758-8939
Endokrinologie
Hund

Primäre Hypothyreose beim Hund – Eine Diagnose mit Hindernissen

Julia Kinny-Köster
,
Imke Lankenau
,
Jennifer von Luckner
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Die Hypothyreose wird beim Hund häufig überdiagnostiziert. Eine besondere Herausforderung liegt dabei in der Differenzierung zwischen Patienten mit einer primären Hypothyreose und solchen mit einer nicht thyreoidalen Erkrankung.

Publication History

Article published online:
22 April 2022

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  • Literatur

  • 1 Pijnacker T, Kooistra AS, Vermeulen CF. et al. Use of basal and TRH-stimulated plasma growth hormone concentrations to differentiate between primary hypothyroidism and nonthyroidal illness in dogs. J Vet Intern Med 2018; 32 (04) 1319-1324
    CrossrefPubMedSearch in Google Scholar
  • 2 Schiel RE, Sist MD, Nachreiner RF. et al. Assessment of criteria used by veterinary practitioners to diagnose hypothyroidism in sighthounds and investigation of serum thyroid hormone concentrations in healthy Salukis. J Am Vet Med Assoc 2010; 236 (03) 302-308
    CrossrefPubMedSearch in Google Scholar
  • 3 Boretti FS, Sieber-Ruckstuhl NS, Favrot C. Evaluation of recombinant human thyroid-stimulating hormone to test thyroid function in dogs suspected of having hypothyroidism. Am J Vet Res 2006; 67 (12) 2012-2016
    CrossrefPubMedSearch in Google Scholar
  • 4 Mooney CT. Canine Hypothyroidism. In: Ettinger SJ, Feldmann EC, Côté E. Textbook of Veterinary Internal Medicine. St. Louis(MO): Elsevier; 2017
    Search in Google Scholar
  • 5 Scott-Moncrieff JC. Hypothyroidism. In: Feldman EC, Nelson RW. Reusch CE et al.. Canine & Feline Endocrinology. St. Louis(MO): Elsevier; 2019
    Search in Google Scholar
  • 6 Nelson RW, Della Maggiore A. Hypothyroidism in dogs. In: Nelson RW, Couto CG. Small Animal Internal Medicine. St. Louis(MO): Elsevier; 2019
    Search in Google Scholar
  • 7 Soler Arias EA, Castillo VA, Garcia JD, Fyfe JC. Congenital dyshormogenic hypothyroidism with goiter caused by a sodium/iodine symporter (SLC5A5) mutation in a family of Shi-Tzu dogs. Domest Anim Endocrinol 2018; 65: 1-8
    CrossrefPubMedSearch in Google Scholar
  • 8 Castillo VA, Pisarev MA, Lalia JC. et al. Commercial diet induced hypothyroidism due to high iodine. A histological and radiological analysis. Vet Q 2001; 23 (04) 218-223
    CrossrefPubMedSearch in Google Scholar
  • 9 Shiel RE, Acke E, Puggioni A. et al. Tertiary hypothyroidism in a dog. Ir Vet J 2007; 60 (02) 88-93
    CrossrefPubMedSearch in Google Scholar
  • 10 Graham PA, Refsal KR, Nachreiner RF. Etiopathologic Findings of Canine Hypothyroidism. Vet Clin Small Anim Pract 2007; 37: 617-631
    CrossrefPubMedSearch in Google Scholar
  • 11 Mooney CT. Canine hypothyroidism: A review of aetiology and diagnosis. N Z Vet J 2011; 59: 105-114
    CrossrefPubMedSearch in Google Scholar
  • 12 Nachreiner RF, Refsal KR, Graham PA, Bowmann MM. Prevalence of serum thyroid hormone autoantibodies in dogs with clinical signs of hypothyroidism. J Am Vet Med Assoc 2002; 220 (04) 466-471
    CrossrefPubMedSearch in Google Scholar
  • 13 Schachter S, Nelson RW, Scott-Moncrieff C, Ferguson DC. et al. Comparison of serum-free thyroxine concentrations determined by standard equilibrium dialysis, modified equilibrium dialysis, and 5 radioimmunoassays in dogs. J Vet Intern Med 2004; 18 (03) 259-264
    CrossrefPubMedSearch in Google Scholar
  • 14 Dixon RM, Reid SW, Mooney CT. Epidemiological, clinical, haematological and biochemical characteristics of canine hypothyroidism. Vet Rec 1999; 145 (17) 481-487
    CrossrefPubMedSearch in Google Scholar
  • 15 Scott-Moncrieff JC. Clinical signs and concurrent diseases of hypothyroidism in dogs and cats. Vet Clin Small Anim Pract 2007; 37 (04) 709-722
    CrossrefPubMedSearch in Google Scholar
  • 16 Dodds WJ. Behavioral changes associated with thyroid dysfunction in dogs. Proceedings Am Hol Vet med Assoc 1999; 80-82
    Search in Google Scholar
  • 17 Mesich MLL, Mayhew PD, Paek M. Gall bladder mucoceles and their association with endocrinopathies in dogs: A retrospective case-control study. J Small Anim Pract 2009; 50: 630-635
    CrossrefPubMedSearch in Google Scholar
  • 18 Finora K, Greco D. Hypothyroidism and myxedema coma. Compend Contin Educ Vet 2007; 29: 19-31
    PubMedSearch in Google Scholar
  • 19 Rossmeisel JH, Duncan RB, Inzana KD. et al. Longitudinal study of the effects of chronic hypothyroidism on skeletal muscle in dogs. Am J Vet Res 2009; 70 (07) 879-889
    CrossrefPubMedSearch in Google Scholar
  • 20 Fracassi F, Tamborini A. Reversible megaoesophagus associated with primary hypothyroidism in a dog. Vet Rec 2011; 168 (12) 329b
    CrossrefPubMedSearch in Google Scholar
  • 21 Aicher KM, Cullen JM, Seiler GS. et al. Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonogrphic diagnosis of gallbladder mucocele formation. J Small Anim Pract 2019; 14 (02) e0212638
    Search in Google Scholar
  • 22 Blois SL, Dickie E, Kruth SA, Alle DG. Multiple endocrine diseases in dogs: 35 cases. J Am Vet Med Assoc 2011; 238 (12) 1616-1621
    CrossrefPubMedSearch in Google Scholar
  • 23 Barrie J, Watson TDG, Stear MJ, Nash AS. Plasma cholesterol and lipoprotein concentrations in the dog: The effects of age, breed, gender and endocrine disease. J Small Anim Pract 1993; 34: 507-512
    CrossrefSearch in Google Scholar
  • 24 Reusch CE, Gerber B, Boretti FS. Serum fructosamine concentrations in dogs with hypothyroidism. Vet Res Commun 2002; 26 (07) 531-536
    CrossrefPubMedSearch in Google Scholar
  • 25 Hofer-Inteeworn N, Panciera DL, Monroe WE. et al. Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs. Am J Vet Res 2012; 73 (04) 529-538
    CrossrefPubMedSearch in Google Scholar
  • 26 Kantrowitz LB, Peterson ME, Melián C. Serum total thyroxine, total triiodothyronine, free thyroxine and thyrotropin concentrations in dogs with nonthyroidal disease. J Am Vet Med Assoc 2001; 219: 765-769
    CrossrefPubMedSearch in Google Scholar
  • 27 Scott-Moncrieff JC, Nelson RW, Bruner JM, Williams DA. Comparison of serum concentrations of thyroid-stimulating hormone in healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease. J Am Vet Med Assoc 1998; 212 (03) 387-391
    PubMedSearch in Google Scholar
  • 28 Graham PA. Clinical pathology challenges in hypothyroidism diagnosis. ECVIM Proceedings. 2021
    Search in Google Scholar
  • 29 Gottschalk J, Einspanier A, Ungemach FR, Abraham G. Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs. Res Vet Sci 2011; 90 (03) 491-497
    CrossrefPubMedSearch in Google Scholar
  • 30 Daminet S, Ferguson DC. Influence of drugs on thyroid function in dogs. J Vet Intern Med 2003; 17: 463-472
    CrossrefPubMedSearch in Google Scholar
  • 31 Daminet S, Croubels S, Duchateau L. et al. Influence of acetylsalicylic acid and ketoprofen on canine thyroid function tests. Vet J 2003; 166 (03) 224-232
    CrossrefPubMedSearch in Google Scholar
  • 32 Gulikers KP, Panciera DL. Evaluation of the effects of clomipramine on canine thyroid function tests. J Vet Intern Med 2003; 17: 44-49
    CrossrefPubMedSearch in Google Scholar
  • 33 Sauvé F, Paradis M, Refsal KR. et al. Effects of oral administration of meloxicam, carprofen, and a nutraceutical on thyroid function in dogs with osteoarthritis. Can Vet J 2003; 44 (03) 474-479
    PubMedSearch in Google Scholar
  • 34 Panciera DL, Refsal KR, Sennello KA, Ward DL. Effects of deracoxib and aspirin on serum concentrations of thyroxine, 3,5,3′-triiodothyronine, free thyroxine, and thyroid-stimulating hormone in healthy dogs. Am J Vet Res 2006; 67 (04) 599-603
    CrossrefPubMedSearch in Google Scholar
  • 35 Seelig DM, Whittemore JC, Lappin MR. et al. Goitrous hypothyroidism associated with treatment with trimethoprim-sulfamethoxazole in a young dog. J Am Vet Med Assoc 2008; 232 (08) 1181-1185
    CrossrefPubMedSearch in Google Scholar
  • 36 Brenner K, Schermerhorn T. Iatrogenic, sulfonamide-induced hypothyroid crisis in a Labrador Retriever. Aust Vet J 2009; 87: 503-505
    CrossrefPubMedSearch in Google Scholar
  • 37 Shiel RE, Brennan SF, Omodo-Eluk AJ, Mooney CT. Thyroid hormone concentrations in young, healthy, pretraining greyhounds. Vet Rec 2007; 161: 616-619
    CrossrefPubMedSearch in Google Scholar
  • 38 Randolph JF, Lamb SV, Cheraskin JL. et al. Free thyroxine concentrations by equilibrium dialysis and chemiluminescent immunoassays in 13 hypothyroid dogs positive for thyroglobulin antibody. J Vet Intern Med 2015; 29 (03) 877-881
    CrossrefPubMedSearch in Google Scholar
  • 39 Lurye JC, Behrend EN, Kemppainen R. Evaluation of an in-house enzyme-linked immunosorbent assay for quantitative measurement of serum total thyroxine concentration in dogs and cats. J Am Vet Med Assoc 2002; 221: 243-249
    CrossrefPubMedSearch in Google Scholar
  • 40 Anderson R, Mueller R, Reese S, Wehner A. Evaluation of an automated enzyme-linked fluorescent assay for thyroxine measurement in cat and dog sera. J Vet Diagn Invest 2017; 29 (03) 278-286
    CrossrefPubMedSearch in Google Scholar
  • 41 Wolff EDS, Bilbrough G, Moore G. et al. Comparison of 2 assays for measuring serum total thyroxine concentration in dogs and cats. J Vet Intern Med 2020; 34 (02) 607-615
    CrossrefPubMedSearch in Google Scholar
  • 42 Nishii N, Okada R, Matsuba M. et al. Risk factors for low plasma thyroxine and high plasma thyroid-stimulating hormone concentrations in dogs with non-thyroidal diseases. J Vet Med Sci 2019; 81 (08) 1097-1103
    CrossrefPubMedSearch in Google Scholar
  • 43 Peterson ME, Nichols MR. Measurement of serum total thyroxine, triiodothyronine, free thyroxine, and thyrotropin concentrations for diagnosis of hypothyroidism in dogs. J Am Vet Med Assoc 1997; 211: 1396-1402
    PubMedSearch in Google Scholar
  • 44 Boretti FS, Breyer-Haube I, Kaspers B, Reusch CE. Klinische, hämatologische, biochemische und endokrinologische Aspekte bei 32 Hunden mit Hypothyreose. Schweiz Arch Tierheilk 2003; 145 (04) 149-159
    CrossrefPubMedSearch in Google Scholar
  • 45 Diaz Espineira MM, Mol JA, Peeters ME. et al. Assessment of Thyroid Function in Dogs with Low Plasma Thyroxine Concentration. J Vet Intern Med 2007; 21 (01) 25-32
    CrossrefPubMedSearch in Google Scholar
  • 46 Dixon RM, Mooney CT. Canine serum thyroglobulin autoantibodies in health, hypothyroidism and non-thyroidal illness. Res Vet Sci 1999; 66: 243-246
    CrossrefPubMedSearch in Google Scholar
  • 47 Corsini A, Faroni E, Lunetta F, Fracassi F. Recombinant human thyrotropin stimulation test in 114 dogs with suspectd hypothyroidism: a cross-sectional study. J Small Anim Pract 2021; 62 (04) 257-264
    CrossrefPubMedSearch in Google Scholar
  • 48 De Roover K, Duchateau L, Charmichael N. et al. Effect of storage of reconstituted recombinant human thyroid-stimulating hormone (rhTSH) on thyroid-stimulating hormone (TSH) response testing in euthyroid dogs. J Vet Intern Med 2006; 20 (04) 812-817
    CrossrefPubMedSearch in Google Scholar
  • 49 Shiel RE, Pinilla M, McAllister H, Mooney CT. Assessment of the value of quantitative thyroid scintigraphy for determination of thyroid function in dogs. J Small Anim Prac 2012; 53 (05) 278-285
    CrossrefPubMedSearch in Google Scholar
  • 50 Ziglioli V, Panciera DL, Troy GC. et al. Effects of levothyroxine administration and withdrawal on the hypothalamic-piruitary-thyroid axis in euthyroid dogs. J Vet Intern Med 2017; 31 (03) 705-710
    CrossrefPubMedSearch in Google Scholar
  • 51 Kooistra HS. True hypothyroidism or non-thyroidal illness. ECVIM Proceedings. 2021
    Search in Google Scholar