New Markers for Placental Dysfunction at Term – Potential for More

Oliver Graupner; Bettina Kuschel; Roland Axt-Fliedner; Christian Enzensberger

doi:10.1055/a-1761-1337

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2022; 82(07): 719-726
DOI: 10.1055/a-1761-1337

GebFra Science

Review

Neue Marker der plazentaren Dysfunktion am Entbindungstermin – Potenzial für mehr

Article in several languages: English | deutsch

Oliver Graupner

¹Klinik für Gynäkologie und Geburtsmedizin, Universitätsklinikum Aachen, RWTH Aachen, Aachen

²Frauenklinik und Poliklinik, Universitätsklinikum rechts der Isar, Technische Universität München, München

,

Bettina Kuschel

²Frauenklinik und Poliklinik, Universitätsklinikum rechts der Isar, Technische Universität München, München

,

Roland Axt-Fliedner

³Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum UKGM, Justus-Liebig-Universität Gießen, Gießen

,

Christian Enzensberger

¹Klinik für Gynäkologie und Geburtsmedizin, Universitätsklinikum Aachen, RWTH Aachen, Aachen

› Author Affiliations

Abstract

Zusammenfassung

Die verbleibende plazentare Reserve am Entbindungstermin ist entscheidend für die perinatale Morbidität von Kind und Mutter. Angesichts des Fortschritts im Bereich der fetalen Überwachung sind die bislang routinemäßig eingesetzten Untersuchungstechniken am Termin bzw. in der Terminüberschreitung womöglich unzureichend, wenn es um die Detektion der subklinischen plazentaren Dysfunktion (PD) geht. Ziel dieser Arbeit ist es, eine aktuelle, narrative Literaturübersicht im Kontext der PD-Detektion am Termin mittels komplementärer US- bzw. Biomarker zu geben. Zu den potenziellen PD-Markern zählen Parameter der fetomaternalen Doppler-Sonografie bzw. fetalen kardialen Funktion sowie (anti-)angiogene Faktoren im Serum der Mutter. Diese könnten eine Rolle spielen, wenn es um die verbesserte Selektion derjenigen Patientinnen geht, bei denen eine elektive, frühzeitige Geburtseinleitung am Entbindungstermin womöglich zur Reduktion der perinatalen Morbidität und Mortalität führt. Ihren Stellenwert bezogen auf die Frage des idealen Entbindungszeitpunkts gilt es jedoch vorerst in randomisiert-kontrollierten Studien mit großer Fallzahl zu klären.

Schlüsselwörter

Plazenta - Ultraschall - Schwangerschaft - Geburtseinleitung

Full Text

References

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