Recent Advances of LncRNA H19 in Diabetes

Ye Bi; Yao Wang; Xianglan Sun

doi:10.1055/a-1769-5032

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2022; 54(04): 212-219
DOI: 10.1055/a-1769-5032

Review

Recent Advances of LncRNA H19 in Diabetes

Ye Bi

¹Department of Geriatrics, Shandong First Medical University, Jinan, China

,

Yao Wang

²Shandong Institute of Endocrine and Metabolic Diseases, Medical University, Jinan, China

,

Xianglan Sun

¹Department of Geriatrics, Shandong First Medical University, Jinan, China

› Author Affiliations

Abstract

Diabetes mellitus (DM) causes damage to major organs, including the heart, liver, brain, kidneys, eyes, and blood vessels, threatening the health of the individuals. Emerging evidence has demonstrated that lncRNAs has important functions in the pathogenesis of human diseases, such as cancers, neurodegenerative diseases, cardiac fibroblast phenotypes, hypertension, heart failure, atherosclerosis and diabetes. Recently, H19, a lncRNA, has been reported to shown to participate in the regulatory process of muscle differentiation, glucose metabolism, and tumor metastasis, as well as endometrial development. However, the roles of H19 in DM were still not completely understood. This review was conducted to summarize the functions of H19 in diabetes and discuss the challenges and possible strategies of H19 in DM.

Key words

diabetes mellitus - LncRNA H19 - H19 function

Full Text

References

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